Results 61 to 70 of about 3,471 (162)

Post‐marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data

open access: yesHeadache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1128-1147, May 2026.
Abstract Objective Calcitonin gene‐related peptide (CGRP) inhibitors, including monoclonal antibodies (mAbs) and small‐molecule antagonists (gepants), have transformed migraine treatment. Although clinical trials established their efficacy and initial safety, post‐marketing surveillance is essential for understanding their real‐world safety profile in ...
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Association between sleep disorders, hyperacusis and tinnitus: Evaluation with tinnitus questionnaires

open access: yesNoise and Health, 2013
Patients with tinnitus are heterogeneous and several factors influence the impact of this symptom on the quality of life. The aim of the study is to evaluate the relationship between age, gender, sleep disorders, hyperacusis and tinnitus annoyance and to
Alessandra B Fioretti   +2 more
doaj   +1 more source

Brimonidine Therapy for Protection From Noise‐Induced Hearing Loss

open access: yesAging Cell, Volume 25, Issue 4, April 2026.
In this study, we demonstrate that brimonidine protects against noise‐induced hearing loss in young mice by suppressing glutamate synthesis and vesicle transport, thereby reducing excitotoxicity and preserving synaptic integrity. Such early intervention may prevent age‐related hearing loss, highlighting brimonidine's potential as a therapeutic agent ...
Jing Cai   +10 more
wiley   +1 more source

Hyperacusis: major research questions [PDF]

open access: yesHNO, 2018
Hyperacusis is a troublesome symptom that can have a marked negative impact on quality of life.To identify major research questions in hyperacusis.Review of gaps in knowledge regarding hyperacusis, and where opportunities may lie to address these.Eight major research questions were identified as priorities for future research.
Baguley, D. M., Hoare, D. J.
openaire   +2 more sources

Unilateral hyperacusis in a normal-hearing child

open access: yesThe Egyptian Journal of Otolaryngology, 2017
There is some debate on the epidemiological data of childhood tinnitus and hyperacusis. It is vital for Audiologists to pay careful attention to minor complaints such as hyperacusis in children to manage them successfully.
Tayseer T. A. Rahman
doaj   +1 more source

Exploring the Neural Substrates of Number Sense: A Perspective on Genetics, Behaviour and Neural Circuity

open access: yesEuropean Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Numerical cognition arises from conserved mechanisms linking genes, neural circuits and behaviour. Using zebrafish as a tractable model, behavioural assays, whole‐brain imaging and genetic analyses can be integrated to identify neural and molecular bases of quantity discrimination. This framework provides a platform for studying numerical cognition and
Mirko Zanon   +3 more
wiley   +1 more source

Selective Disruption of Salience‐Network Anterior Insula Connectivity in Misophonia: A Disorder‐Specific Neural Signature

open access: yesHuman Brain Mapping, Volume 47, Issue 3, 15 February 2026.
Using resting‐state functional connectivity in a large sample of adults from the general population, our results provide neural evidence that misophonia is a discrete spectrum disorder (separate from anxiety, depression, and autism) and has a characteristic neural signature of salience insular connectivity. ABSTRACT Misophonia, a disorder characterized
Heather A. Hansen   +4 more
wiley   +1 more source

Efficacy and Safety of Intratympanic Botulinum Toxin Injection on Middle Ear Myoclonic Tinnitus

open access: yesThe Laryngoscope, Volume 136, Issue 1, Page 403-410, January 2026.
Intratympanic Botulinum toxin (IT‐BTX) injection appears to be an effective and safe treatment for MEMT, significantly reducing tinnitus‐related symptoms without complications. In a retrospective study of 57 patients, THI scores and VAS measures for loudness, awareness, annoyance, and life impact improved significantly over 6 months.
Ji Hyung Lim   +8 more
wiley   +1 more source

Pontine Hemorrhage Mimicking Bell’s Palsy: Isolated Facial Nerve Palsy—A Case Report

open access: yesCase Reports in Neurological Medicine, Volume 2026, Issue 1, 2026.
Bell’s palsy, the most common cause of idiopathic peripheral facial palsy, is typically attributed to viral reactivation; however, rare cases due to cerebrovascular disease must always be considered in the differential diagnosis. We report the case of a 75‐year‐old man with poorly controlled hypertension, diabetes mellitus, and a history of smoking who
Rei Takeichi   +5 more
wiley   +1 more source

Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network

open access: yeseLife, 2015
Hearing loss often triggers an inescapable buzz (tinnitus) and causes everyday sounds to become intolerably loud (hyperacusis), but exactly where and how this occurs in the brain is unknown.
Yu-Chen Chen   +13 more
doaj   +1 more source

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