Results 71 to 80 of about 5,263 (183)

Post‐marketing safety of CGRP monoclonal antibodies and gepants: A systematic review of spontaneous reporting system data

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1128-1147, May 2026.
Abstract Objective Calcitonin gene‐related peptide (CGRP) inhibitors, including monoclonal antibodies (mAbs) and small‐molecule antagonists (gepants), have transformed migraine treatment. Although clinical trials established their efficacy and initial safety, post‐marketing surveillance is essential for understanding their real‐world safety profile in ...
Martina Giacon, Salvatore Terrazzino
wiley   +1 more source

Brimonidine Therapy for Protection From Noise‐Induced Hearing Loss

Aging Cell, Volume 25, Issue 4, April 2026.
In this study, we demonstrate that brimonidine protects against noise‐induced hearing loss in young mice by suppressing glutamate synthesis and vesicle transport, thereby reducing excitotoxicity and preserving synaptic integrity. Such early intervention may prevent age‐related hearing loss, highlighting brimonidine's potential as a therapeutic agent ...
Jing Cai, Na Zhang, Yongdong Song, Chengfang Chen, Ligang Kong, Yu Ai, Yu Jin, Qian Gao, Daogong Zhang, Lei Xu, Haibo Wang   +10 more
wiley   +1 more source

Exploring the Neural Substrates of Number Sense: A Perspective on Genetics, Behaviour and Neural Circuity

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
Numerical cognition arises from conserved mechanisms linking genes, neural circuits and behaviour. Using zebrafish as a tractable model, behavioural assays, whole‐brain imaging and genetic analyses can be integrated to identify neural and molecular bases of quantity discrimination. This framework provides a platform for studying numerical cognition and
Mirko Zanon, Caroline H. Brennan, Maria Elena Miletto Petrazzini, Jose V. Torres‐Pérez   +3 more
wiley   +1 more source

Hyperacusis among adults with occupational noise exposure [PDF]

Introduction: Hyperacusis is an increased sensitivity and reduced tolerance to sounds at an acceptable level for most people. This research effort addresses this critical gap in understanding the role of occupational workers as one of the contributing ...
Mat Nasir, Nurul Lydia Nazifa, Ismail, Noraidah, Tengku Zam Zam, Tengku Zulaila Hasma   +2 more
core   +1 more source

SOUNDS LIKE INTOLERANCE: : A BROADENINGOF HYPERACUSIS EVALUATION

, 2023
Hyperacusis is a condition that is described by abnormal reactions to ordinary sounds, however, because of its complexity and newness, this diagnosis still lacks centralized definition and established prevalence rates.
Larsson, William, Sceglova, Tatjana
core   +2 more sources

Validation of screening questions for hyperacusis in chronic tinnitus [PDF]

, 2015
Background. We investigated the validity of the two hyperacusis items of the TSCHQ(Tinnitus Sample CaseHistory Questionnaire) from the TRI (Tinnitus Research Initiative) database by comparing them with the German hyperacusis questionnaire GUF.
Vielsmeier, Veronika, Schecklmann, Martin, Lehner, Astrid, Schlee, Winfried, Landgrebe, Michael, Langguth, Berthold   +5 more
core   +1 more source

Defining tinnitus: a socratic and epistemological inquiry

Frontiers in Audiology and Otology
Defining tinnitus using a Socratic approach poses a philosophical challenge: identifying features that are shared by all instances of tinnitus and only tinnitus.
Hashir Aazh
doaj   +1 more source

Tinnitus and hyperacusis involve hyperactivity and enhanced connectivity in auditory-limbic-arousal-cerebellar network

eLife, 2015
Hearing loss often triggers an inescapable buzz (tinnitus) and causes everyday sounds to become intolerably loud (hyperacusis), but exactly where and how this occurs in the brain is unknown.
Yu-Chen Chen, Xiaowei Li, Lijie Liu, Jian Wang, Chun-Qiang Lu, Ming Yang, Yun Jiao, Feng-Chao Zang, Kelly Radziwon, Guang-Di Chen, Wei Sun, Vijaya Prakash Krishnan Muthaiah, Richard Salvi, Gao-Jun Teng   +13 more
doaj   +1 more source

Hyperacusis in vestibular migraine successfully treated with galcanezumab: A case report

Cephalalgia Reports
Background Hyperacusis, a heightened sensitivity to sound, can severely impair quality of life and remains difficult to treat. Case We report a 44-year-old woman with vestibular migraine who experienced persistent dizziness, tinnitus, and hyperacusis ...
Fumiyuki Goto, Shouji Kaneda, Koichiro Wasano, Kenji Okami   +3 more
doaj   +1 more source

Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis

Frontiers in Neuroscience
IntroductionBoth tinnitus and hyperacusis, likely triggered by hearing loss, can be attributed to maladaptive plasticity in auditory perception. However, owing to their co-occurrence, disentangling their neural mechanisms proves difficult.
Naoki Wake, Tomoyo I. Shiramatsu, Hirokazu Takahashi   +2 more
doaj   +1 more source