Results 251 to 260 of about 85,056 (307)
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Current Opinion in Supportive & Palliative Care, 2010
Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
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Opioids are invaluable in the treatment of moderate-to-severe pain. Unfortunately, their prolonged use may be associated with the onset of opioid-induced hyperalgesia (OIH). This review focuses on recent clinical studies that support or refute the existence of OIH in patients.Whether or not OIH is a clinical reality is an ongoing debate.
Kirsty, Bannister, Anthony H, Dickenson
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Journal of PeriAnesthesia Nursing, 2012
HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Chris, Pasero, Margo, McCaffery
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HYPERALGESIAMEANS INCREASED sensitivity to pain. Opioid-induced hyperalgesia (OIH) is a paradoxical situation in which increasing doses of opioid result in increasing sensitivity to pain. OIH has been identified as a clinical reality, but the incidence of clinically significant OIH is unknown.
Chris, Pasero, Margo, McCaffery
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Spinal Mediators of Hyperalgesia
Drugs, 1994Neuronal plasticity associated with altered sensations arising from tissue damage involves both established (e.g. substance P and excitatory amino acids) and novel (e.g. nitric oxide and metabolites of arachidonic acid) mediators released from terminals of primary afferent neurons or synthesised in the spinal cord.
S T, Meller, G F, Gebhart
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Journal of Musculoskeletal Pain, 2002
SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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SUMMARYObjectives: The aim of this paper is to give a brief introduction to the mechanisms and manifestations related to muscle hyperalgesia. It has become increasingly evident that muscle hyperalgesia plays an important role in chronic musculoskeletal pain.
Arendt-Nielsen, Lars +1 more
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Opioid Tolerance and Hyperalgesia
Medical Clinics of North America, 2007Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain.
Grace, Chang, Lucy, Chen, Jianren, Mao
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Hyperalgesia and opioid switching
American Journal of Hospice and Palliative Medicine®, 2005Opioids, intended to abolish pain, can unexpectedly produce hyperalgesia, particularly during rapid opioid escalation. Opioid switching could be a therapeutic option in a condition of opioid-induced tolerance or hyperalgesia, but conversion ratios between opioids are difficult to apply in this context and require strict surveillance and expertise ...
Sebastiano, Mercadante, Edoardo, Arcuri
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Kinins and their receptors in hyperalgesia
Canadian Journal of Physiology and Pharmacology, 1997Kinins (bradykinin, kallidin) are produced at sites of injury and inflammation and serve a critical role in signaling tissue distress as well as organising tissue responsiveness to injury. The acute activation and prolonged sensitization of fine afferents, to produce pain and hyperalgesia, are important in the protective responses that occur to ...
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Synaptic mechanisms of hyperalgesia
2000Publisher Summary Hyperalgesia and allodynia often aggravate pain for variable periods after trauma, surgery, and inflammation. Pain that is induced by normally nonpainful stimuli (allodynia) or abnormally intense pain elicited by noxious stimuli (hyperalgesia) may be the consequence of an increased sensitivity of nociceptors (peripheral ...
J, Sandkühler +4 more
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G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia
Journal of Molecular Neuroscience, 2017Tissue injury, pathogen infection, and diseases are often accompanied by inflammation to release mediators that sensitize nociceptors and further recruit immune cells, which can lead to chronic hyperalgesia and inflammation. Tissue acidosis, occurring at the inflammatory site, is a major factor contributing to pain and hyperalgesia.
Yeu-Shiuan Su +5 more
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Ethanol Withdrawal and Hyperalgesia
Current Drug Abuse Reviewse, 2009Hyperalgesia has been observed during ethanol withdrawal, comparable to the hyperalgesia observed during withdrawal from opioids. To determine the extent of this phenomenon and its potential mechanisms, both behavioral and in vitro studies are examined, and the roles of GABA(A), glutamate and other receptors in mediating the acute and chronic ...
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