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Mechanical allodynia [PDF]

Pflügers Archiv - European Journal of Physiology, 2014
Mechanical allodynia (other pain) is a painful sensation caused by innocuous stimuli like light touch. Unlike inflammatory hyperalgesia that has a protective role, allodynia has no obvious biological utility. Allodynia is associated with nerve damage in conditions such as diabetes, and is likely to become an increasing clinical problem.
Lolignier, Stéphane, Eijkelkamp, Niels, Wood, John   +2 more
openaire   +6 more sources

Endothelin receptor type A is involved in the development of oxaliplatin-induced mechanical allodynia and cold allodynia acting through spinal and peripheral mechanisms in rats

Molecular Pain, 2021
Oxaliplatin, a platinum-based chemotherapeutic agent, frequently causes severe neuropathic pain typically encompassing cold allodynia and long-lasting mechanical allodynia.
Kae Matsuura, Atsushi Sakai, Yuji Watanabe, Yasunori Mikahara, Atsuhiro Sakamoto, Hidenori Suzuki   +5 more
doaj   +1 more source

The Relationship Between the Presence of Allodynia and Pain Acceptance and Somatosensory Amplification in Patients with Migraine

Haseki Tıp Bülteni, 2023
Aim:Allodynia is a pain disorder that adversely affects the prognosis of migraine and reduces the quality of life of patients with migraine. Thus, the study evaluated the relationship between the presence of allodynia and psychiatric aspects such as ...
Aysu Yakin Olgun, Buse Rahime Hasirci Bayir, Ruziye Erol Yildiz, Sencan Sertcelik   +3 more
doaj   +1 more source

Cutaneous allodynia as predictor for treatment response in chronic migraine: a cohort study

The Journal of Headache and Pain, 2023
Background Central sensitisation is an important mechanism in migraine chronification. It is presumed to occur in second and third order neurons sequentially, resulting in an analogous spatial distribution of cutaneous allodynia with cephalic and ...
Judith A. Pijpers, Dennis A. Kies, Erik W. van Zwet, Irene de Boer, Gisela M. Terwindt   +4 more
doaj   +1 more source

BDNF-TrkB signaling pathway-mediated microglial activation induces neuronal KCC2 downregulation contributing to dynamic allodynia following spared nerve injury

Molecular Pain, 2023
Mechanical allodynia can be evoked by punctate pressure contact with the skin (punctate mechanical allodynia) and dynamic contact stimulation induced by gentle touching of the skin (dynamic mechanical allodynia).
Zihan Hu, Xinren Yu, Pei Chen, Keyu Jin, Jing Zhou, Guoxiang Wang, Jiangning Yu, Tong Wu, Yulong Wang, Fuqing Lin, Tingting Zhang, Yun Wang, Xuan Zhao   +12 more
doaj   +1 more source

Ultrasound-Guided combined greater occipital nerve block at the C2 level with trapezius trigger point injection and supraorbital-Supratrochlear nerve block: More effective on allodynia and disability in chronic migraine

Annals of Indian Academy of Neurology, 2023
Background: Chronic migraine (CM) patients with cutaneous allodynia (CA) show a poor response to treatment. Long-term studies have yet to be conducted to demonstrate the efficacy of blocks on CA.
Suna Aşkın Turan, şenay Aydın, Melih G Gözükara, Murat Çabalar   +3 more
doaj   +1 more source

The Histamine H₄ Receptor Participates in the Anti-Neuropathic Effect of the Adenosine A₃ Receptor Agonist IB-MECA: Role of CD4⁺ T Cells

Biomolecules, 2021
A3 adenosine receptor (A3AR) agonists have emerged as potent relievers of neuropathic pain by a T cell-mediated production of IL-10. The H4 histamine receptor (H4R), also implicated in pain modulation, is expressed on T cells playing a preeminent role in
Laura Micheli, Mariaconcetta Durante, Elena Lucarini, Silvia Sgambellone, Laura Lucarini, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Emanuela Masini   +7 more
doaj   +1 more source

Kinin B₂ Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation

Pharmaceuticals, 2023
Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1 ...
Gabriela Becker, Maria Fernanda Pessano Fialho, Evelyne Silva Brum, Sara Marchesan Oliveira   +3 more
doaj   +1 more source

Vitamin D, Chronic Migraine, and Extracranial Pain: Is There a Link? Data From an Observational Study

Frontiers in Neurology, 2021
Several studies focused on the role of vitamin D (vitD) in pain chronification. This study focused on vitD level and pain chronification and extension in headache disorders.
Valentina Rebecchi, Daniela Gallo, Daniela Gallo, Lucia Princiotta Cariddi, Lucia Princiotta Cariddi, Eliana Piantanida, Eliana Piantanida, Payam Tabaee Damavandi, Payam Tabaee Damavandi, Federico Carimati, Marco Gallazzi, Alessandro Clemenzi, Paola Banfi, Elisa Candeloro, Maria Laura Tanda, Maria Laura Tanda, Marco Mauri, Marco Mauri, Maurizio Versino, Maurizio Versino   +19 more
doaj   +1 more source

Pharmacological Differences Between Static and Dynamic Allodynia in Mice With Herpetic or Postherpetic Pain

Journal of Pharmacological Sciences, 2008
In the present study, we investigated whether dynamic and static allodynia would be developed in the affected dermatome in murine models of herpetic pain and postherpetic neuralgia and pharmacologically characterized the allodynia.
Atsushi Sasaki, Kenichi Serizawa, Tsugunobu Andoh, Kimiyasu Shiraki, Hiroki Takahata, Yasushi Kuraishi   +5 more
doaj   +1 more source