Results 31 to 40 of about 34,712 (269)
Spinal NKCC1 blockade inhibits TRPV1-dependent referred allodynia
Molecular Pain, 2007 Background The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult.
Cervero Fernando +3 more
doaj +1 more source
Neuropathic Pain: Mechanism, Representation, Management and Treatment
International Clinical Neuroscience Journal, 2022 Despite the development of screening tests and diagnostic tools, neuropathic pain is still identified as an underdiagnosed condition lacking proper epidemiological studies. It is difficult to estimate its incidence and prevalence the population.
Amir Saied Seddighi +4 more
doaj +1 more source
The Journal of Headache and Pain, 2019 Background OnabotulinumtoxinA is effective in treating chronic migraine (CM), but there are limited data assessing how allodynia affects preventive treatment responses.
William B. Young +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 The inflammatory cartilaginous degeneration of the articular joints, mostly those of knee, hips and hands, is osteoarthritis (OA). The available treatment strategies for osteoarthritis are designed for pain relief, molecular targeting, cartilage ...
Acharya Balkrishna +8 more
doaj +1 more source
Thermo-Sensitive TRP Channels: Novel Targets for Treating Chemotherapy-Induced Peripheral Pain
Frontiers in Physiology, 2017 Abnormal Ca2+ channel physiology, expression levels, and hypersensitivity to heat have been implicated in several pain states following treatment with chemotherapeutic agents.
Mustafa Nazıroğlu, Nady Braidy
doaj +1 more source
Stress-induced changes in nociceptive responding post-surgery in preclinical rodent models
Frontiers in Pain Research, 2023 Chronic post-surgical pain affects up to 85% of individuals depending on the type of surgery, the extent of inflammation, tissue and/or nerve damage. Pre-surgical stress is associated with greater pain intensity, prolonged recovery and is one of the main
Ariadni Bella +11 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park +6 more
doaj +1 more source
Antioxidants, 2022 Chronic inflammatory pain is manifested in many diseases. The potential use of molecular hydrogen (H2) as a new therapy for neurological disorders has been demonstrated.
Santiago Coral-Pérez +6 more
doaj +1 more source
Pathophysiology and Therapy of Associated Features of Migraine
Cells, 2022 Migraine is a complex and debilitating disorder that is broadly recognised by its characteristic headache. However, given the wide array of clinical presentations in migraineurs, the headache might not represent the main troublesome symptom and it can ...
Maria Dolores Villar-Martinez +1 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 Our previous studies have clarified that red nucleus (RN) interleukin (IL)-6 is involved in the maintenance of neuropathic pain and produces a facilitatory effect by activating JAK2/STAT3 and ERK pathways.
Qing-Qing Yang +11 more
doaj +1 more source