Results 41 to 50 of about 41,646 (248)

Antihyperalgesic Properties of Honokiol in Inflammatory Pain Models by Targeting of NF-κB and Nrf2 Signaling

Frontiers in Pharmacology, 2018
The present study investigates the possible anti-nociceptive effect of intraperitoneal (i.p.) honokiol: a phenolic compound originally isolated from Magnolia officinalis, in acute and chronic inflammatory pain models.
Sidra Khalid, Muhammad Z. Ullah, Ashraf U. Khan, Ruqayya Afridi, Hina Rasheed, Adnan Khan, Hussain Ali, Yeong S. Kim, Salman Khan   +8 more
doaj   +1 more source

Mechanical Punctate Pain Thresholds in Patients With Migraine Across Different Migraine Phases: A Narrative Review

Frontiers in Neurology, 2022
Purpose of the ReviewWe reviewed the studies of mechanical punctate pain thresholds (MPTs) in patients with migraine and summarized their findings focusing on the differences in MPT measurement and MPTs in different phases of migraine.MethodsWe searched ...
Li-Ling Hope Pan, Rolf-Detlef Treede, Shuu-Jiun Wang, Shuu-Jiun Wang, Shuu-Jiun Wang   +4 more
doaj   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

A Randomized, Sham‐Controlled Trial of Repetitive Transcranial Magnetic Stimulation Targeting M1 and S2 in Central Poststroke Pain: A Pilot Trial

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Central poststroke pain (CPSP), a neuropathic pain condition, is difficult to treat. Repetitive transcranial magnetic stimulation (rTMS) targeted to the primary motor cortex (M1) can alleviate the condition, but not all patients respond. We aimed to assess a promising alternative rTMS target, the secondary somatosensory cortex (S2),
Juhani Ojala, Jukka Vanhanen, Hanna Harno, Pantelis Lioumis, Selja Vaalto, Mari A. Kaunisto, Jukka Putaala, Marko Kangasniemi, Erika Kirveskari, Jyrki P. Mäkelä, Eija Kalso   +10 more
wiley   +1 more source

ErbB4 in Spinal PV Interneurons Regulates Mechanical Allodynia in Neuropathic Pain via Modulation of Glycinergic Inhibitory Tone

, 2021
Yingying Yu, Guohua Wei, Qi Zhou, Huanhuan Sha Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, People’s Republic of ChinaCorrespondence: Huanhuan ...
Zhou Q, Sha H, Wei G, Yu Y
core  

The Edible Brown Seaweed Ecklonia cava Reduces Hypersensitivity in Postoperative and Neuropathic Pain Models in Rats

Molecules, 2014
The current study was designed to investigate whether edible brown seaweed Ecklonia cava extracts exhibits analgesic effects in plantar incision and spared nerve injury (SNI) rats. To evaluate pain-related behavior, we performed the mechanical withdrawal
Jae Goo Kim, Dong Wook Lim, Suengmok Cho, Daeseok Han, Yun Tai Kim   +4 more
doaj   +1 more source

Concurrent Long Thoracic and Lateral Cutaneous Intercostal Nerve Entrapment After Chest Tube Thoracostomy Causing Scapular Winging and Chest Wall Pain: Diagnosis With Ultrasound and Treatment With Hydrodissection. [PDF]

Pain Pract
ABSTRACT Background Chest tube thoracostomy may cause iatrogenic nerve injury, resulting in persistent pain and functional impairment. Long thoracic nerve (LTN) palsy after chest tube placement has been described, but concurrent involvement of the LTN and the lateral cutaneous branch of an intercostal nerve (LCIN) appears to be rarely reported.
Yoon Y, Lam KHS, Su DC, Suryadi T, Suhaimi A.   +4 more
europepmc   +2 more sources

VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis

Advanced Science, EarlyView.
Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang, Bing‐Jie Tang, Jia‐Yi Li, Shu‐Lan Xie, Shumin Duan, Junping Chen, Shengmei Zhu, Zhen‐Zhong Xu   +7 more
wiley   +1 more source

Targeting CXCR2 in Nociceptive Sensory Neurons Offers Novel Therapeutic Potentials for Postoperative Pain

Advanced Science, EarlyView.
Tissue incision induces CXCL5 release, which activates neuronal CXCR2 on incision‐innervating sensory neurons. Neuronal CXCR2 couples with TRPA1 to drive mechanical pain and engages p38 MAPK signaling to upregulate TRPV1 and promote heat pain. Targeted Cxcr2 knockdown relieves incisional pain while preserving CXCR2‐dependent neutrophil responses ...
Yushuang Pan, Peiyi Li, Yufeng Chen, Zishan Dong, Yuanyuan Li, Boyu Liu, Yan Tai, Chuan Wang, Jianqiao Fang, Chengyu Yin, Boyi Liu   +10 more
wiley   +1 more source

Cutaneous tactile allodynia associated with microvascular dysfunction in muscle [PDF]

, 2008
Background: Cutaneous tactile allodynia, or painful hypersensitivity to mechanical stimulation of the skin, is typically associated with neuropathic pain, although also present in chronic pain patients who do not have evidence of nerve injury. We examine
Laferriere, A, Gary J Bennett, Sachot, C, Dimitris N Xanthos, Xiao, WH, Mos, Marissa, Xanthos Dimitris N, Bennett Gary J, Bennett, G.J. (Gary), Magali Millecamps, Coderre, TJ, Millecamps, M. (Magali), Siau, C. (Chiang), Xiao Wen, Andre Laferrière, Huygen Frank JPM, Chiang Siau, Millecamps, M, Ragavendran, V, Wen Hua Xiao, Mos, M. (Marieke) de, Coderre, T.J. (Terence), Sachot Christelle, Marissa de Mos, Coderre Terence J, Christelle Sachot, Frank JPM Huygen, Huygen, FJPM, de Mos Marissa, Xiao, W.H., Laferrière Andre, Xanthos, DN, Xanthos, D.N. (Dimitiris), Millecamps Magali, Laferriere, A., Ragavendran J Vaigunda, Bennett, GJ, Siau Chiang, J Vaigunda Ragavendran, Sachot, C. (Christelle), Ragavendran, J.V. (Vaigunda), Huygen, F.J.P.M. (Frank), Siau, C, Terence J Coderre   +43 more
core   +2 more sources