Results 61 to 70 of about 41,646 (248)

Allodynia and Self-Efficacy in Migraineurs [PDF]

, 2019
Headache disorders are among the most comdisorders of the nervous system, with migraine alone affecting 14% of women and 6% of men worldwide each year.
Polk, Ashley N.
core   +1 more source

Inflammation, mechanical allodynia and an exaggerated exercise pressor reflex during disease progression in UCD-type 2 diabetes mellitus rats. [PDF]

Exp Physiol
Abstract Chronic low‐grade inflammation characterizes type 2 diabetes mellitus (T2DM) and underlies the development of peripheral neuropathy, symptoms of which include mechanical allodynia and an exaggerated exercise pressor reflex. The purpose of this study was to determine whether mechanical allodynia and/or specific concentrations of inflammatory ...
Harrison ML, McCuller RK, Huo Y, Gajula AN, Ybarbo K, Van Ryzin MJ, Stanhope KL, Havel PJ, Stone AJ.   +8 more
europepmc   +2 more sources

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, EarlyView.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Allodynia and hyperalgesia: review

, 2018
The main purpose was to highlight the problem of hyperalgesia and allodynia. Main anatomic structures, which participate in nociception were mentioned in this article, with pathologic and pathophysiologic changes, that can be caused by hyperalgesia and ...
K. D. Dmytriiev, O. V. Marchuk
core   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Characterization of Migraineurs Having Allodynia

, 2016
Objective: Allodynia reflects the clinical correlate of central sensitization, but it is usually neglected in clinical headache management. We aimed to report the prevalence and previously unnoticed associations of allodynia in migraineurs by a ...
Aksel Siva, Ekizoglu, Esme, Zarifoglu, Mehmet, Elif Kocasoy-Orhan, Mehmet Zarifoglu, Kocasoy-Orhan, Elif, Siva, Aksel, Baykan, BETÜL, Necdet Karli, Mustafa Ertas, Sabahattin Saip, Ertas, Mustafa, Esme Ekizoglu, Betul Baykan, Saip, Sabahattin, Karli, Necdet   +15 more
core   +1 more source

Beyond Pain Relief: Unveiling the Multifaceted Impact of Anti-CGRP/R mAbs on Comorbid Symptoms in Resistant Migraine Patients

Biomedicines
The study aimed to evaluate the effects of monoclonal antibodies (mAbs) acting on the calcitonin gene-related peptide (CGRP) or its receptor (anti-CGRP/R mAbs) on migraine comorbidities of depression, anxiety, and fatigue in patients resistant to ...
Alessandra Della Vecchia, Ciro De Luca, Lucrezia Becattini, Letizia Curto, Elena Ferrari, Gabriele Siciliano, Sara Gori, Filippo Baldacci   +7 more
doaj   +1 more source

Allodynia in different forms of migraine

, 2007
About 60% of patients complain of cutaneous allodynia during migraine episodes, often in the periorbitary region of the pain side. Pre-clinical studies have shown that the underlying mechanism is sensitisation of primary nociceptors and central ...
P. Bertora, C. Lovati, M. Suardelli, E. Mailland, G. Bussone, C. Mariani, S. Pomati, S. Rosa, D. D'Amico   +8 more
core   +1 more source

RNA Sequencing Dataset of Drosophila Nociceptor Translatomic Response to Injury

Data
To prepare to address the mechanisms of injury-induced nociceptor sensitization, we sequenced the translatome of the nociceptors of injured Drosophila larvae and those of uninjured larvae.
Christine M. Hale, Kyle J. Beauchemin, Courtney L. Brann, Julie K. Moulton, Ramaz Geguchadze, Benjamin J. Harrison, Geoffrey K. Ganter   +6 more
doaj   +1 more source

Efficacy and safety of laparoscopic nerve decompression for neuropathic sciatic pain due to endometriosis: A systematic review and meta‐analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Endometriosis is associated with neuropathic pain in approximately 40% of cases. Involvement of the sciatic nerve or sacral plexus represents one of the most frequently reported neuropathic pain presentations in endometriosis, for which no specific management guidelines currently exist.
Camille Racca, Julia Franken, Marion Cahen, Aurelly Cicchelero, Murielle Mormont, Raphaël Cinotti   +5 more
wiley   +1 more source