Results 41 to 50 of about 114,297 (258)

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

p.Cys223Tyr mutation causing Crigler–Najjar syndrome type II

JGH Open, 2020
Crigler–Najjar syndrome (CNs) is a rare hereditary unconjugated hyperbilirubinemia caused by mutations in the bilirubin Uridine (UDP) glucuronosyltransferase family 1 member A1 (UGT1A1, ENSG00000241635) gene.
Qing‐Fang Xiong, Hui Zhou, Yong‐Feng Yang   +2 more
doaj   +1 more source

Clinical Significance of Acute Kidney Injury in Idiosyncratic Drug‐Induced Liver Injury: A Multicentric Propensity Scores Matched Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical significance of acute kidney injury in idiosyncratic drug‐induced liver injury: a multicentric propensity scores matched study. Evidence about the role of acute kidney injury (AKI) in idiosyncratic drug‐induced liver injury (DILI) is still scarce.
José María Pinazo‐Bandera, Hao Niu, Juan Pedro Toro‐Ortiz, Inmaculada Medina‐Caliz, Judith Sanabria‐Cabrera, Aída Ortega‐Alonso, Mercedes Robles‐Díaz, Daniel Enrique Di Zeo‐Sanchez, Nelia Hernández, Fernando Bessone, Vinicius Nunes, Raymundo Paraná, M. Isabel Lucena, Raul J. Andrade, Ismael Alvarez‐Alvarez, Miren García‐Cortés   +15 more
wiley   +1 more source

Defective biliary secretion of bile acid 3-O-glucuronides in rats with hereditary conjugated hyperbilirubinemia.

Journal of Lipid Research, 1989
Biliary secretion of bile acid glucuronides was studied in control rats and in rats with a congenital defect in hepatobiliary transport of organic anions (GY rats).
F Kuipers, A Radominska, P Zimniak, J M Little, R Havinga, R J Vonk, R Lester   +6 more
doaj   +1 more source

Early indicators of neonatal‐onset hereditary thrombotic thrombocytopenia purpura

Research and Practice in Thrombosis and Haemostasis, 2022
Background Neonatal‐onset hereditary thrombotic thrombocytopenia purpura (hTTP) is often misdiagnosed due to its rarity. It begins with jaundice, similar to infants with ABO incompatibility.
Jing Liu, Yuelun Zhang, Zhuo Li, Zhenghong Li, Lejia Zhang, Shan Jian, Changyan Wang, Yuqing Song, Zichao Lv, Xiaoyan Tang, Lijuan Gou, Juan Xiao   +11 more
doaj   +1 more source

Reversal of surgical biliary diversion with ileal bile acid transport inhibitors: A new chapter in progressive familiar intrahepatic cholestasis type 1 management?

JPGN Reports, EarlyView.
Abstract Progressive Familial Intrahepatic Cholestasis type 1 (PFIC1) is a multisystem disorder. Although liver transplant (LT) resolves the hepatic disease, post‐LT complications may occur, including severe enteropathy and graft steatosis caused by impaired bile acids handling by the native intestine.
Teresa Botelho, Giulia Jannone, Roberto Tambucci, Catherine de Magnee, Isabelle Scheers, Etienne Sokal, Xavier Stephenne   +6 more
wiley   +1 more source

Ultrasound findings associated with neonatal acute liver failure secondary to gestational alloimmune liver disease: A case series

JPGN Reports, EarlyView.
Abstract Objectives Gestational alloimmune liver disease is the leading cause of neonatal acute liver failure, hypothesized to emerge from maternal exposure to an antigen that is expressed on fetal hepatocytes, resulting in maternal‐fetal alloimmune attack and activation of the complement cascade.
Naseem Ravanbakhsh, Ashley M. Upton, Chun‐Sing Huang, Nhu Thao N. Galván, John Goss, Sanjiv Harpavat, Jose A. Hernandez   +6 more
wiley   +1 more source

A construction for quasi-hereditary algebras [PDF]

, 1989
Dlab V, Ringel CM. A construction for quasi-hereditary algebras. Compositio Mathematica.
Dlab, Vlastimil, Ringel, Claus Michael
core  

The hereditary angioedema burden of illness study in Europe (HAE-BOIS-Europe) : background and methodology [PDF]

, 2012
Background: Hereditary angioedema (HAE) is a rare but serious disease marked by swelling attacks in the extremities, face, trunk, airway, or abdominal areas that can be spontaneous or the result of trauma and other triggers.
Beusterien, Kathleen, Caballero, Teresa, Boysen, Henrik, Boysen, Henrik B., Musingarimi, Patience, Emel Aygören-Pürsün, Kathleen Beusterien, Gholizadeh, Shadi, Bygum, Anette, Wait, Suzanne, Patience Musingarimi, Aygören-Pürsün, Emel, Teresa Caballero, Suzanne Wait, Henrik Boysen, Anette Bygum, Shadi Gholizadeh, Bygum, Anette; id_orcid   +17 more
core   +2 more sources

Machine Learning‐Based Risk Stratification Tool for Hearing Loss in High‐Risk Neonates

The Laryngoscope, EarlyView.
Machine learning models, particularly XGBoost, provide robust risk stratification for neonatal hearing loss by capturing complex interactions among clinical risk factors such as NICU stay duration and family history. To translate these predictive capabilities into routine practice, an open‐access web‐based clinical decision support tool was developed ...
Sevgi Kutlu, Emre Söylemez, Betül Temir, Esranur Ulusoy, Zahide Çiler Büyükatalay   +4 more
wiley   +1 more source