Results 31 to 40 of about 813 (218)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The Features of The Hyperbolic Slab Waveguide

EPJ Web of Conferences, 2015
The dispersion relation determining guided TE and TM modes are found for the slab hyperbolic waveguide. The waveguide is consisting of an isotropic dielectric slab bounded by hyperbolic media.
Lyashko E. I., Maimistov A. I.
doaj   +1 more source

Translation-Based Embeddings with Octonion for Knowledge Graph Completion

Applied Sciences, 2022
Knowledge representation learning achieves the automatic completion of knowledge graphs (KGs) by embedding entities into continuous low-dimensional vector space.
Mei Yu, Chen Bai, Jian Yu, Mankun Zhao, Tianyi Xu, Hongwei Liu, Xuewei Li, Ruiguo Yu   +7 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Density of systoles of hyperbolic manifolds

Comptes Rendus. Mathématique
We show that for each $n \ge 2$, the systoles of closed hyperbolic $n$-manifolds form a dense subset of $(0, +\infty )$. We also show that for any $n\ge 2$ and any Salem number $\lambda $, there is a closed arithmetic hyperbolic $n$-manifold of systole $\
Douba, Sami, Huang, Junzhi
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Predicting and Comparing the Subjective Health Experience of Older Cancer Survivors and Non‐Cancer Survivors: A Modeling Approach

Aging and Cancer, EarlyView.
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst, Sjaak Bloem, Eline J. Mertens, Nathascha Hanzen, Michel van Agthoven   +4 more
wiley   +1 more source

Shape invariance of solvable Schrödinger equations with a generalized hyperbolic tangent superpotential

Results in Physics, 2022
Supersymmetric quantum mechanics provides a powerful method for solving the Schrödinger equation in quantum mechanics problems. In this paper, a hyperbolic tangent superpotential is generalized according to a new hyperbolic tangent superpotential.
Shi-Kun Zhong, Ting-Yao Xie, Li Dong, Chen-Xi Yang, Lu-Lin Xiong, Min Li, Guang Luo   +6 more
doaj   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source