Results 61 to 70 of about 67,397 (310)

Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss‐of‐Function Gα11 Mutation

open access: yesJournal of Bone and Mineral Research, 2017
G‐protein subunit α‐11 (Gα11) couples the calcium‐sensing receptor (CaSR) to phospholipase C (PLC)‐mediated intracellular calcium (Ca2+i) and mitogen‐activated protein kinase (MAPK) signaling, which in the parathyroid glands and kidneys regulates ...
C. Gorvin   +6 more
semanticscholar   +1 more source

Construction of Chronic Kidney Disease Mouse Model Induced by Diets With Different Adenine Content

open access: yesFood Safety and Health, EarlyView.
By administering a 4 weeks adenine diet to C57BL/6J mice, we identified 0.2% adenine in purified feed as the optimal chronic kidney disease model. This model induces severe renal damage, gut dysbiosis, uremic toxin accumulation, and CKD mineral bone disorder, providing a clinically relevant platform for mechanistic and therapeutic studies.
Wanjun Liao   +8 more
wiley   +1 more source

Clinical Implications of Ki‐67 Index, Grade and Hormonal Changes in Pancreatic Neuroendocrine Tumors: Insights Into Tumor Heterogeneity Based on Primary and Secondary Lesions

open access: yesJournal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background Pancreatic neuroendocrine tumors (PanNETs) show heterogeneity, including temporal shifts in proliferation and hormone production; however, their clinical implications remain uncertain. Methods This retrospective study included 114 patients with metastatic or recurrent PanNETs at Kyushu University Hospital.
Masatoshi Murakami   +9 more
wiley   +1 more source

Multiple Myeloma Presenting as Hypercalcemia-Induced Acute Severe Pancreatitis: A Case Report

open access: yesGastro Hep Advances
Hypercalcemia is a known presentation of multiple myeloma along with anemia, renal failure, and bone pains (CRAB: hypercalcemia, renal failure, anemia, and bone lesions).
Anjuman Fayaz   +3 more
doaj   +1 more source

Performance of the pro-FHH score in a delayed diagnosis of familial hypocalciuric hypercalcemia type-1

open access: yesJournal of Clinical and Translational Endocrinology Case Reports, 2021
We present a case of a 50-year-old woman with familial hypocalciuric hypercalcemia type 1 (FHH-1) that was missed during an initial evaluation of hypercalcemia in the setting of normal serum parathyroid hormone (PTH), leading to unnecessary ...
Akuffo Quarde   +2 more
doaj   +1 more source

Severe hypercalcemia due to drowning in an onsen (hot spring)

open access: yesJournal of Emergencies, Trauma and Shock, 2023
Hypercalcemia is generally caused by primary hyperparathyroidism, malignancies, and drugs. Herein, we report a case of severe hypercalcemia due to drowning in hot springs.
Daisuke Ueno   +3 more
doaj   +1 more source

Calcimimetic Use in Familial Hypocalciuric Hypercalcemia—A Perspective in Endocrinology

open access: yesJournal of Clinical Endocrinology and Metabolism, 2017
Context: Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia that even persists after subtotal parathyroidectomy. Symptoms are usually mild.
S. Marx
semanticscholar   +1 more source

Ovarian cancer presenting with hypercalcemia: two cases with similar manifestations but different mechanisms

open access: yesCancer Biology & Medicine, 2018
Hypercalcemia presenting in ovarian cancer is uncommon in the clinic. Here, two cases of ovarian epithelial carcinoma that presented with severe hypercalcemia were reported, with a review of the literature.
Xuegong Ma   +5 more
doaj   +1 more source

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