Results 31 to 40 of about 9,796 (177)

Disruption of Claudin‐2 and Trpv6 Results in Hypocalcemia, Hypercalciuria, and Altered Bone Microarchitecture in Mice

open access: yesActa Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Transepithelial calcium absorption occurs via a transcellular or paracellular pathway. The intestinal transcellular pathway relies, at least partially, on the apical calcium channel transient receptor potential vanilloid 6 (TRPV6), whereas paracellular calcium (re)absorption occurs through tight junction proteins, including claudin‐2 (CLDN2 ...
Harneet Kaur Bhullar   +6 more
wiley   +1 more source

Outcomes and adverse effects of teduglutide treatment with periodic withdrawal in pediatric short bowel patients

open access: yesJournal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 1, Page 37-45, July 2026.
Abstract Objectives We evaluated the efficacy and safety of teduglutide in a real‐world cohort in which national reimbursement policies required treatment interruptions. The primary outcomes were reduction in parenteral support (PS) and treatment‐related adverse effects, and the secondary outcome was the impact of the mandated withdrawal periods ...
Riikka Gunnar   +3 more
wiley   +1 more source

Kidney and Metabolic Phenotypes in Glycogen Storage Disease Type-I Patients

open access: yesFrontiers in Pediatrics, 2020
Patients and Methods: A retrospective chart review of 32 GSD- I patients, followed at the American University of Beirut Medical Center, between 2007 and 2018 was conducted. Diagnosis was confirmed by enzymatic and/or genetic studies.
Bilal Aoun   +5 more
doaj   +1 more source

Design of Nanocarriers for Kidney Targeted Delivery of Nucleic Acid Therapeutics

open access: yesMacromolecular Bioscience, Volume 26, Issue 7, July 2026.
Nucleic acid therapeutics have been investigated to expand their applications to renal genetic disorders. This review summarizes key considerations in the design and fabrication of nanocarriers for the systemic delivery of nucleic acid therapeutics to the kidneys.
Jun Hyuk Lee   +3 more
wiley   +1 more source

Comparison of urinary sodium and potassium in children older than two with idiopathic hypercalciuria and a healthy control group in Bandar-Abbas, Iran, in 2013

open access: yesElectronic Physician, 2014
Background: Idiopathic hypercalciuria is an important cause of symptoms related to the urinary system. The urinary excretion of high sodium and low potassium is a risk factor for hypercalciuria and urolithiasis. The aim of this study was to compare the
Elham Ajdadi   +3 more
doaj   +1 more source

Vitamin D receptor (VDR) contributes to the development of hypercalciuria by sensitizing VDR target genes to vitamin D in a genetic hypercalciuric stone-forming (GHS) rat model

open access: yesGenes and Diseases, 2022
Human idiopathic hypercalciuria (IH) is the most common cause of calcium oxalate nephrolithiasis with perturbed calcium metabolism with increased bone resorption and decreased renal calcium reabsorption, which can be phenotype-copied in the genetic ...
Shang Guo   +5 more
doaj   +1 more source

Dietary Acid Load and Kidney Stones: NEAP Shows a Positive Association in a Nationally Representative Sample

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
Higher NEAP was associated with higher odds of kidney stones in US adults; PRAL showed a weaker/borderline association after full adjustment. ABSTRACT This study aimed to examine the associations of Dietary acid load (DAL), estimated by net endogenous acid production (NEAP) and potential renal acid load (PRAL), with the prevalence of kidney stones in ...
Yunfan Chen, Qiyu He
wiley   +1 more source

Hyperuricosuria and hypercalciuria, probable etiologies of functional abdominal pain: A case–control study

open access: yesJournal of Research in Medical Sciences, 2022
Background: Functional abdominal pain (FAP) is a common complaint causing several referrals to pediatricians. On the other hand, the most common presentation of hyperuricosuria and also hypercalciuria is chronic/recurrent abdominal pain.
Hossein Saneian   +6 more
doaj   +1 more source

Interpretable Machine Learning for Predicting Metabolic Syndrome–Kidney Stone Disease Comorbidity: The Role of Dietary Micronutrients

open access: yesFood Science &Nutrition, Volume 14, Issue 6, June 2026.
This study used NHANES 2007–2018 data to develop interpretable machine learning models for predicting MetS–KSD comorbidity using dietary micronutrients and demographic variables. Random Forest and XGBoost showed the best performance under different modeling strategies, and key dietary micronutrient predictors varied according to model context ...
Guanwei Wu   +7 more
wiley   +1 more source

Idiopathic Hypercalciuria in Children With Vesico Ureteral Reflux and Recurrent Urinary Tract Infection

open access: yesUrology Journal, 2010
Purpose: Our aim was to determine association of vesicoureteral reflux (VUR) and idiopathic hypercalciuria in children with recurrent and single episode of urinary tract infection (UTI).Materials and Methods: The study group consisted of 45 children with
Hashem Mahmoodzadeh
doaj  

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