Results 161 to 170 of about 2,568 (202)
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Archives of Neurology, 1983
Hyperekplexia is a hereditary neurologic disorder manifested by an exaggerated startle response, generalized muscular rigidity, and prominent nocturnal myoclonus. The distinctive features of this syndrome constitute an unusual clinical entity that is easily mistaken for other disorders.
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Hyperekplexia is a hereditary neurologic disorder manifested by an exaggerated startle response, generalized muscular rigidity, and prominent nocturnal myoclonus. The distinctive features of this syndrome constitute an unusual clinical entity that is easily mistaken for other disorders.
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Epileptic Disorders, 2004
ABSTRACT We report on the case of an 86‐year‐old woman who rapidly became unable to stand and walk because of jerky movements, suggesting a clinical diagnosis of myoclonus. It was observed that both unexpected and expected stimuli (audiogenic, tactile, or visual) triggered the myoclonic jerks.
Sophie, Hamelin +4 more
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ABSTRACT We report on the case of an 86‐year‐old woman who rapidly became unable to stand and walk because of jerky movements, suggesting a clinical diagnosis of myoclonus. It was observed that both unexpected and expected stimuli (audiogenic, tactile, or visual) triggered the myoclonic jerks.
Sophie, Hamelin +4 more
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Neurology India, 2022
Hyperekplexia, an underdiagnosed motor paroxysm of infancy, mimics epilepsy closely. It is hallmarked by episodic and excessive startle response, brief episodes of intense, generalized hypertonia, or stiffness in response to unexpected auditory and/or tactile stimuli right from birth.
Juhi, Gupta +5 more
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Hyperekplexia, an underdiagnosed motor paroxysm of infancy, mimics epilepsy closely. It is hallmarked by episodic and excessive startle response, brief episodes of intense, generalized hypertonia, or stiffness in response to unexpected auditory and/or tactile stimuli right from birth.
Juhi, Gupta +5 more
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Neonatal Hyperekplexia: A Case Report
Epilepsia, 1992Summary: We report the case of a baby with transient generalized stiffness noticeable from the first days of life, hyperreflexia, massive jerks in response to sudden tactile and acoustic stimuli, and long‐lasting myoclonic jerks closely resembling epileptic seizures. The father and paternal grandfather both had hyperekplexia. At age 3 years, the child
PASCOTTO, Antonio, COPPOLA G.
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The effects of clonazepam and vigabatrin in hyperekplexia
Journal of the Neurological Sciences, 1997Hyperekplexia is an autosomal dominant disorder caused by a point mutation in the alpha1 subunit of the glycine receptor, characterized by excessive startle responses followed by temporary generalized stiffness. Clonazepam, effective in open case studies, potentiates, through unknown mechanisms, the neurotransmitter gamma-aminobutyric acid (GABA ...
Tijssen, M. A. +5 more
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Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994
The paper reports a case of a rare neurological syndrome, hyperekplexia. A 46[correction of 38]-year-old man had secondary hyperekplexia in the presence of unusual associated clinical symptoms (periodical kinesiogenic dystonia and episodes of severe laryngospasms) and mild circulatory disorder in the brain trunk area.
O R, Orlova, V L, Golubev, D V, Artem'ev
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The paper reports a case of a rare neurological syndrome, hyperekplexia. A 46[correction of 38]-year-old man had secondary hyperekplexia in the presence of unusual associated clinical symptoms (periodical kinesiogenic dystonia and episodes of severe laryngospasms) and mild circulatory disorder in the brain trunk area.
O R, Orlova, V L, Golubev, D V, Artem'ev
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Hyperekplexia and sudden neonatal death
Pediatric Neurology, 1992Fifteen patients with hyperekplexia were identified in 3 families; diagnostic clinical characteristics were defined which allowed for early recognition and treatment. During the first 24 hours of life, spontaneous apnea and sluggish feeding effort were observed. After the first 24 hours, surviving infants exhibited the hyperekplexic startle response to
M A, Nigro, H C, Lim
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Physiological abnormalities in hereditary hyperekplexia
Annals of Neurology, 1992AbstractFive patients from a kindred with hereditary hyperekplexia had physiological testing. The surface‐recorded electromyographic pattern of audiogenic muscle jerks was identical to that of the normal acoustic startle reflex. Testing at graded stimulus intensities indicated an increase in the gain of the acoustic startle reflex.
J, Matsumoto +3 more
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Anesthetic Management of a Parturient with Hyperekplexia
A & A Case Reports, 2015Hyperekplexia is a hereditary disorder characterized by exaggerated startle reflex in response to unexpected acoustic, tactile, and other stimuli. Neonates with hyperekplexia may present with hypertonia, developmental delays, apnea, and sudden death. The diagnosis is based on published clinical criteria.
Anthony, Chau +3 more
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Hyperekplexia: a treatable neurogenetic disease
Brain and Development, 2002Hyperekplexia is primarily an autosomal dominant disease characterized by exaggerated startle reflex and neonatal hypertonia. It can be associated with, if untreated, sudden infant death from apnea or aspiration pneumonia and serious injuries and loss of ambulation from frequent falls.
Lan, Zhou +2 more
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