Glycine and glycine receptor signalling in non-neuronal cells [PDF]
Frontiers in Molecular Neuroscience, 2009 Glycine is an inhibitory neurotransmitter acting mainly in the caudal part of the central nervous system. Besides this neurotransmitter function, glycine has cytoprotective and modulatory effects in different non-neuronal cell types.
Jimmy Van Den Eynden +8 more
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Impaired Verbal Memory Recall in Patients With Axonal Degeneration and Serum Glycine-Receptor Autoantibodies—Case Series [PDF]
Frontiers in Psychiatry, 2022 BackgroundGlycine receptor antibody-associated neuropsychiatric disease is currently known to be dominated by the phenotypes stiff-person syndrome and progressive encephalomyelitis entailing rigidity and myoclonus. In our case series we aim to depict the
Niels Hansen +6 more
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Molecular determinants of cesium- and glycine-dependent glycine receptor activation [PDF]
Scientific ReportsThe neurotransmitter receptor for glycine (GlyR) is a ligand-gated chloride-permeable ion channel in the central nervous system, and dysregulation of this channel is associated with diverse neurological disorders. Cesium (Cs+) is an agonist of GlyRs, and
Magnus Harnau +3 more
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Glycine receptor autoantibody binding to the extracellular domain is independent from receptor glycosylation [PDF]
Frontiers in Molecular Neuroscience, 2023 Glycine receptor (GlyR) autoantibodies are associated with stiff-person syndrome and the life-threatening progressive encephalomyelitis with rigidity and myoclonus in children and adults.
Vera Rauschenberger +13 more
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The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders [PDF]
Frontiers in Molecular NeuroscienceRare neurodevelopmental disorders (NDDs) are one of the most significant unmet challenges in healthcare due to their lifelong nature, high management costs, and recurrence within families.
Sean D. Fraser +3 more
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Mechanism of gating and partial agonist action in the glycine receptor [PDF]
Cell, 2021 Hongtao Zhu +2 more
exaly +2 more sources
Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. [PDF]
PLoS ONE, 2012 BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease.
Florian Wegner +7 more
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Positive Modulation of the Glycine Receptor by Means of Glycine Receptor–Binding Aptamers [PDF]
SLAS Discovery, 2015 According to the gate control theory of pain, the glycine receptors (GlyRs) are putative targets for development of therapeutic analgesics. A possible approach for novel analgesics is to develop a positive modulator of the glycine-activated Cl(-) channels.
Shalaly ND +8 more
openaire +5 more sources
Inhibitory Glycine Receptors: An Update [PDF]
Journal of Biological Chemistry, 2012 Strychnine-sensitive glycine receptors (GlyRs) mediate synaptic inhibition in the spinal cord, brainstem, and other regions of the mammalian central nervous system. In this minireview, we summarize our current view of the structure, ligand-binding sites, and chloride channel of these receptors and discuss recently emerging functions of distinct GlyR ...
Dutertre, Sebastien +2 more
openaire +6 more sources
Frontiers in Psychiatry, 2020 Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant impact on the functional outcome and on the global burden of disease.
Andrea de Bartolomeis +6 more
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