Results 1 to 10 of about 262,271 (117)

Impaired Verbal Memory Recall in Patients With Axonal Degeneration and Serum Glycine-Receptor Autoantibodies—Case Series [PDF]

Frontiers in Psychiatry, 2022
BackgroundGlycine receptor antibody-associated neuropsychiatric disease is currently known to be dominated by the phenotypes stiff-person syndrome and progressive encephalomyelitis entailing rigidity and myoclonus. In our case series we aim to depict the
Niels Hansen, Claudia Bartels, Winfried Stöcker, Jens Wiltfang, Jens Wiltfang, Jens Wiltfang, Dirk Fitzner   +6 more
doaj   +2 more sources

Molecular determinants of cesium- and glycine-dependent glycine receptor activation [PDF]

Scientific Reports
The neurotransmitter receptor for glycine (GlyR) is a ligand-gated chloride-permeable ion channel in the central nervous system, and dysregulation of this channel is associated with diverse neurological disorders. Cesium (Cs+) is an agonist of GlyRs, and
Magnus Harnau, Elina Zeller, Steffen Fricke, Jochen C. Meier   +3 more
doaj   +2 more sources

The emerging role of glycine receptor α2 subunit defects in neurodevelopmental disorders [PDF]

Frontiers in Molecular Neuroscience
Rare neurodevelopmental disorders (NDDs) are one of the most significant unmet challenges in healthcare due to their lifelong nature, high management costs, and recurrence within families.
Sean D. Fraser, Sean D. Fraser, Robert J. Harvey, Robert J. Harvey   +3 more
doaj   +2 more sources

Differentiated human midbrain-derived neural progenitor cells express excitatory strychnine-sensitive glycine receptors containing α2β subunits. [PDF]

PLoS ONE, 2012
BACKGROUND: Human fetal midbrain-derived neural progenitor cells (NPCs) may deliver a tissue source for drug screening and regenerative cell therapy to treat Parkinson's disease.
Florian Wegner, Robert Kraft, Kathy Busse, Wolfgang Härtig, Jörg Ahrens, Andreas Leffler, Reinhard Dengler, Johannes Schwarz   +7 more
doaj   +1 more source

Glycine Signaling in the Framework of Dopamine-Glutamate Interaction and Postsynaptic Density. Implications for Treatment-Resistant Schizophrenia

Frontiers in Psychiatry, 2020
Treatment-resistant schizophrenia (TRS) or suboptimal response to antipsychotics affects almost 30% of schizophrenia (SCZ) patients, and it is a relevant clinical issue with significant impact on the functional outcome and on the global burden of disease.
Andrea de Bartolomeis, Mirko Manchia, Mirko Manchia, Federica Marmo, Licia Vellucci, Felice Iasevoli, Annarita Barone   +6 more
doaj   +1 more source

Glycine Potentiates AMPA Receptor Function through Metabotropic Activation of GluN2A-containing NMDA Receptors

Frontiers in Molecular Neuroscience, 2016
NMDA receptors are Ca2+-permeable ion channels. The activation of NMDA receptors requires agonist glutamate and co-agonist glycine. Recent evidence indicates that NMDA receptor also has metabotropic function.
Li-Jun Li, Rong Hu, Rong Hu, Brendan Lujan, Juan Chen, Jian-Jian Zhang, Yasuko Nakano, Tian-Yuan Cui, Ming-Xia Liao, Jin-Cao Chen, Hengye Man, Hua Feng, Qi Wan, Qi Wan, Qi Wan, Qi Wan   +15 more
doaj   +1 more source

Orexin neurons receive glycinergic innervations. [PDF]

PLoS ONE, 2011
Glycine, a nonessential amino-acid that acts as an inhibitory neurotransmitter in the central nervous system, is currently used as a dietary supplement to improve the quality of sleep, but its mechanism of action is poorly understood.
Mari Hondo, Naoki Furutani, Miwako Yamasaki, Masahiko Watanabe, Takeshi Sakurai   +4 more
doaj   +1 more source

Actions of N-arachidonyl-glycine in a rat inflammatory pain model

Molecular Pain, 2007
Background While cannabinoid receptor agonists have analgesic activity in inflammatory pain states they produce a range of side effects. Recently, it has been demonstrated that the arachidonic acid-amino acid conjugate, N-arachidonyl-glycine (NA-glycine)
Vaughan Christopher W, Mitchell Vanessa A, Succar Rebecca   +2 more
doaj   +1 more source

Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes

Frontiers in Molecular Neuroscience, 2022
SLC6A20A is a proline and glycine transporter known to regulate glycine homeostasis and NMDA receptor (NMDAR) function in the brain. A previous study found increases in ambient glycine levels and NMDA receptor-mediated synaptic transmission in the brains
Junhyung Kim, Junyeop Daniel Roh, Seongbin Kim, Hyojin Kang, Mihyun Bae, Eunjoon Kim, Eunjoon Kim   +6 more
doaj   +1 more source

Neuroprotection via Strychnine-Sensitive Glycine Receptors During Post-ischemic Recovery of Excitatory Synaptic Transmission in the Hippocampus

Journal of Pharmacological Sciences, 2010
Recent evidence indicates that strychnine-sensitive glycine receptors are located in upper brain regions including the hippocampus. Because of excitatory effects of glycine via facilitation of NMDA-receptor function, however, the net effects of increased
Mitsuo Tanabe, Azusa Nitta, Hideki Ono
doaj   +1 more source