Results 41 to 50 of about 1,587,740 (262)

Glycine/NMDA Receptor Pathway Mediates the Rapid-onset Antidepressant Effect of Alkaloids From Trichilia Monadelpha

Basic and Clinical Neuroscience, 2021
Introduction: Major depressive disorder is often associated with suicidal tendencies, and this condition accentuates the need for rapid-acting antidepressants.
Kennedy Kwami Edem Kukuia, Jeffrey Amoako Mensah, Patrick Amoateng, Dorcas Osei-Safo, Awo Efua Koomson, Joseph Torbi, Donatus Wewura Adongo, Elvis Ofori Ameyaw, Inemesit Okon Ben, Seth Kwabena Amponsah, Kwasi Agyei Bugyei, Isaac Julius Asiedu-Gyekye   +11 more
doaj  

Disturbances of ligand potency and enhanced degradation of the human glycine receptor at affected positions G160 and T162 originally identified in patients suffering from hyperekplexia

Frontiers in Molecular Neuroscience, 2015
Ligand-binding of Cys-loop receptors is determined by N-terminal extracellular loop structures from the plus as well as from the minus side of two adjacent subunits in the pentameric receptor complex. An aromatic residue in loop B of the glycine receptor
Sinem eAtak, Georg eLanglhofer, Natascha eSchaefer, Denise eKessler, Heike eMeiselbach, Carolyn eDelto, Hermann eSchindelin, Carmen eVillmann   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Recombinant glycine receptors: stoichiometry and kinetics [PDF]

, 2009
Glycine receptors (GlyR) are anion-permeable channels that belong to the pentameric ligand-gated ion channel family. Different GlyR subtypes are known. The main synaptic form is thought to be α1β heteropentamers which mediate fast synaptic inhibition in ...
Krashia, P.
core  

Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies [PDF]

, 2005
<p><b>Background and Purpose:</b> Glycine Antagonist in Neuroprotection (GAIN) International and GAIN Americas trials were prospectively designed, randomized, placebo-controlled trials of gavestinel, a glycine-site antagonist and ...
Lees, K.R., Brown, D.L., Levin, B., Pittman, J.G., Ordronneau, P., Sacco, R.L., Davis, S., Derosa, J.T., Thompson, J.L.P., Haley, E.C., ORDRONNEAU P, DEROSA J. T, CLARKE HALEY, E. JR, LEVIN, Bruce, THOMPSON J. L. P, PITTMAN J. C, DAVIS, Stephen, LEES, K. L, BROWN, D. L, FOR THE GAIN AMERICAS AND GAIN, DAVIS S, CAROLEI, ANTONIO, PITTMAN, John G, DEROSA, Janet T, ORDRONNEAU, Paul, SACCO R. L, INTERNATIONAL INVESTIGATORS, LEVIN B, HALEY E. C, SACCO, Ralph L, THOMPSON, John L. P, LEES, Kennedy R, BROWN, Devin L   +32 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Anti-Glycine Receptor Antibody Mediated Progressive Encephalomyelitis with Rigidity and Myoclonus Associated with Breast Cancer

Case Reports in Neurological Medicine, 2013
We describe a 66-year-old woman who presented with a dramatic course of PERM. Anti-glycine receptor antibodies were found. She stabilized after plasma-exchange and partly recovered.
Sofie N. De Blauwe, Patrick Santens, Ludo J. Vanopdenbosch   +2 more
doaj   +1 more source

Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs

Scientific Reports, 2020
The glycine receptor (GlyR), a member of the pentameric ligand-gated ion channel family (pLGIC), displays remarkable variations in the affinity and efficacy of the full agonist glycine and the partial agonist taurine depending on the cell system used ...
Max Bernhard, Bodo Laube
doaj   +1 more source

Single-channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens [PDF]

, 2004
The α1β heteromeric receptors are likely to be the predominant synaptic form of glycine receptors in the adult. Their activation mechanism was investigated by fitting putative mechanisms to single-channel recordings obtained at four glycine ...
Burzomato, V., Beato, M., Colquhoun, D., Groot-Kormelink, P.J., Sivilotti, L.G.   +4 more
core  

Distinct pharmacological and functional properties of NMDA receptors in mouse cortical astrocytes [PDF]

, 2011
Background and purpose Astrocytes of the mouse neocortex express functional NMDA receptors which are not blocked by Mg2+ions. However, study of the pharmacological profile of glial NMDARs and their subunit composition is far from complete ...
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin, Ulyana Lalo, Yuriy Pankratov   +5 more
core   +1 more source