Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics [PDF]
Biology of Sex DifferencesBackground Drug metabolism va-specific dosing. Strychnine, the primary active compound in strychnine-based alkaloids, is used for treatment of hemiplegia or amblyopia.
Wen Zhang +7 more
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Anticonvulsant Potential of 1-Aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines: Insights from Strychnine and Nicotine Models in In Vivo and In Silico Studies [PDF]
PharmaceuticalsBackground: Epilepsy is a chronic, non-communicable brain disorder characterized by recurrent seizures. Some derivatives of 1,2,3,4-tetrahydroisoquinolines have demonstrated anticonvulsant effects.
Azizbek A. Azamatov +7 more
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Analytical method for the determination of strychnine in tissues by gas chromatography/mass spectrometry: two case reports [PDF]
Forensic Science International, 2000 This paper describes an analytical method for strychnine determination in biological samples by gas chromatography/mass spectrometry and their application in the investigation of two cases involving strychnine ingestion: A fatal case and a clinical one ...
Marques, E. P. +6 more
exaly +2 more sources
Exploring TAS2R46 biomechanics through molecular dynamics and network analysis [PDF]
Frontiers in Molecular BiosciencesUnderstanding the intricate interplay between structural features and signal-processing events is crucial for unravelling the mechanisms of biomolecular systems.
Marco Cannariato +6 more
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Recent Advances in Total Synthesis of Strychnine (2017-2022) [PDF]
BIO Web of Conferences, 2022 Known for the complexity of its structure, strychnine remains to be one of the challenging targets of total synthesis. Generations of chemists have contributed to the total synthesis of strychnine since Woodward’s groundbreaking synthesis.
Hua Yunkai
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Insects, 2021 The two closely related moth species, Helicoverpa armigera and H. assulta differ strongly in their degree of host-plant specialism. In dual-choice leaf disk assays, caterpillars of the two species that had been reared on standard artificial diet were ...
Dong-Sheng Zhou +2 more
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Gels, 2023 Strychnine (STCN) has demonstrated an exceptional anticancer effect against various cancers. However, the STCN clinical utility has been hampered by its low water solubility, restricted therapeutic window, short half-life, and significant toxicity.
Perwez Alam +3 more
doaj +1 more source
A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. [PDF]
PLoS Biology, 2011 Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of ...
Marijke Brams +8 more
doaj +1 more source
Nature, 2022 Abstract Strychnine is a natural product that, through isolation, structural elucidation and synthetic efforts, shaped the field of organic chemistry. Currently, strychnine is used as a pesticide to control rodents 1 because of its potent neurotoxicity 2 ...
Benke Hong +8 more
openaire +3 more sources
Fatal cases of strychnine ingestion referred to Fars Legal Medicine Organization; Autopsy findings and Analytical methods used in strychnine detection [PDF]
Trends in Pharmaceutical Sciences, 2017 Strychnine is a toxic alkaloid which might be the source of poisoning with homicidal and suicidal purposes. Eleven fatal cases of strychnine ingestion were considered in this study.
Maryam Hosseini +6 more
doaj +2 more sources