Results 1 to 10 of about 25,312 (210)

Recent Advances in Total Synthesis of Strychnine (2017-2022) [PDF]

BIO Web of Conferences, 2022
Known for the complexity of its structure, strychnine remains to be one of the challenging targets of total synthesis. Generations of chemists have contributed to the total synthesis of strychnine since Woodward’s groundbreaking synthesis.
Hua Yunkai
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Biosynthesis of strychnine

Nature, 2022
Abstract Strychnine is a natural product that, through isolation, structural elucidation and synthetic efforts, shaped the field of organic chemistry. Currently, strychnine is used as a pesticide to control rodents 1 because of its potent neurotoxicity 2 ...
Benke Hong, Dagny Grzech, Lorenzo Caputi, Prashant Sonawane, Carlos E. Rodríguez López, Mohamed Omar Kamileen, Néstor J. Hernández Lozada, Veit Grabe, Sarah E. O’Connor   +8 more
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Analysis of sex difference in strychnine-intoxicated rat based on the combination of metabolic kinetics and metabolomics [PDF]

Biology of Sex Differences
Background Drug metabolism va-specific dosing. Strychnine, the primary active compound in strychnine-based alkaloids, is used for treatment of hemiplegia or amblyopia.
Wen Zhang, Chaoren Wang, Haiyun Liu, Sitong Nan, Fenglin Zhang, Congying Liu, Jiangwei Yan, Juan Jia   +7 more
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Fatal cases of strychnine ingestion referred to Fars Legal Medicine Organization; Autopsy findings and Analytical methods used in strychnine detection [PDF]

Trends in Pharmaceutical Sciences, 2017
Strychnine is a toxic alkaloid which might be the source of poisoning with homicidal and suicidal purposes. Eleven fatal cases of strychnine ingestion were considered in this study.
Maryam Hosseini, Abdorrasoul Malekpour, Reza Khoshnoud, Hasan Abbasinia, Saeid Gholamzadeh, Tahereh Tarian, Asiyeh Hashemi   +6 more
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Anticonvulsant Potential of 1-Aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines: Insights from Strychnine and Nicotine Models in In Vivo and In Silico Studies [PDF]

Pharmaceuticals
Background: Epilepsy is a chronic, non-communicable brain disorder characterized by recurrent seizures. Some derivatives of 1,2,3,4-tetrahydroisoquinolines have demonstrated anticonvulsant effects.
Azizbek A. Azamatov, Nilufar Z. Mamadalieva, Asmaa A. Mandour, Sherzod N. Zhurakulov, Urkhiya K. Aytmuratova, Valentina I. Vinogradova, Fazliddin S. Jalilov, Firuza M. Tursunkhodzhaeva   +7 more
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Exploring TAS2R46 biomechanics through molecular dynamics and network analysis [PDF]

Frontiers in Molecular Biosciences
Understanding the intricate interplay between structural features and signal-processing events is crucial for unravelling the mechanisms of biomolecular systems.
Marco Cannariato, Riccardo Fanunza, Eric A. Zizzi, Marcello Miceli, Giacomo Di Benedetto, Marco A. Deriu, Lorenzo Pallante   +6 more
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Habituation to a Deterrent Plant Alkaloid Develops Faster in the Specialist Herbivore Helicoverpa assulta Than in Its Generalist Congener Helicoverpa armigera and Coincides with Taste Neuron Desensitisation

Insects, 2021
The two closely related moth species, Helicoverpa armigera and H. assulta differ strongly in their degree of host-plant specialism. In dual-choice leaf disk assays, caterpillars of the two species that had been reared on standard artificial diet were ...
Dong-Sheng Zhou, Chen-Zhu Wang, Joop J. A. van Loon   +2 more
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Formulation of Transliposomal Nanocarrier Gel Containing Strychnine for the Effective Management of Skin Cancer

Gels, 2023
Strychnine (STCN) has demonstrated an exceptional anticancer effect against various cancers. However, the STCN clinical utility has been hampered by its low water solubility, restricted therapeutic window, short half-life, and significant toxicity.
Perwez Alam, Mohd Imran, Dipak Kumar Gupta, Ali Akhtar   +3 more
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A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors. [PDF]

PLoS Biology, 2011
Cys-loop receptors (CLR) are pentameric ligand-gated ion channels that mediate fast excitatory or inhibitory transmission in the nervous system. Strychnine and d-tubocurarine (d-TC) are neurotoxins that have been highly instrumental in decades of ...
Marijke Brams, Anshul Pandya, Dmitry Kuzmin, René van Elk, Liz Krijnen, Jerrel L Yakel, Victor Tsetlin, August B Smit, Chris Ulens   +8 more
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Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target

BMC Complementary Medicine and Therapies, 2022
Background Improper use of strychnine can cause death. The aim of this study was to identify and evaluate toxic mechanisms of action associated with active compounds in strychnine using a network toxicology approach, and explore potential pathogenic ...
Jialin Dai, Jiangjin Liu, Maoxin Zhang, Yanni Yu, Jie Wang   +4 more
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