A Cation-π Interaction in the Binding Site of the Glycine Receptor Is Mediated by a Phenylalanine Residue [PDF]
, 2008 Cys-loop receptor binding sites characteristically contain many aromatic amino acids. In nicotinic ACh and 5-HT3 receptors, a Trp residue forms a cation-{pi} interaction with the agonist, whereas in GABAA receptors, a Tyr performs this role.
Dougherty, Dennis A. +6 more
core +2 more sources
Moles and Mole Control on British Farms, Amenities and Gardens after Strychnine Withdrawal
Animals, 2016 Moles are considered pests in Britain, but this issue has been little studied. Lower welfare standards have been tolerated for moles than for most other managed wild mammal species, as use of both the controversial poison, strychnine, and unregulated ...
Sandra E. Baker +3 more
doaj +1 more source
Pharmaceuticals, 2021 This research aimed to explore how Strychnine (Str) ion-pair compounds affect the in vitro transdermal process. In order to prevent the influence of different functional groups on skin permeation, seven homologous fatty acids were selected to form ion ...
Lili He +7 more
doaj +1 more source
Conformational variability of the glycine receptor M2 domain in response to activation by different agonists [PDF]
, 2007 Models describing the structural changes mediating cys-loop receptor activation generally give little attention to the possibility that different agonists may promote activation via distinct M2 pore-lining domain structural rearrangements.
Akabas +30 more
core +3 more sources
THE TESTS FOR STRYCHNINE. [PDF]
The Lancetn ...
Rodgers, J. E. D., Girdwood, G. P.
openaire +2 more sources
Simultaneous HPTLC determination of strychnine and brucine in strychnos nux-vomica seed
Journal of Pharmacy and Bioallied Sciences, 2012 Objective: A simple, sensitive, and specific thin layer chromatography (TLC) densitometry method has been developed for the simultaneous quantification of strychnine and brucine in the seeds of Strychnos nux-vomica.
Abid Kamal +4 more
doaj +1 more source
The Usefulness of MS3 to Confirm Poisoning on the Example of Dog Poisoning with Strychnine
Molecules, 2019 Strychnine is an alkaloid with strong toxic properties. Poisoning results in muscular contractions and death through asphyxiation. Intentional or accidental poisonings with strychnine occur mainly in small animals, especially dogs and occasionally cats ...
Tomasz Śniegocki +2 more
doaj +1 more source
Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) [PDF]
Archives of Biological Sciences, 2013 This study aims to investigate the effect of a methanol extract of Trachyspermum ammi (L.) as an antiepileptic agent. Tests were conducted with a single- and multiple-dosing schedule of Trachyspermum ammi (L.), using a strychnine-induced seizure model
Rajput Muhammad Ali +2 more
doaj +1 more source
The full repertoire of Drosophila gustatory receptors for detecting an aversive compound. [PDF]
, 2015 The ability to detect toxic compounds in foods is essential for animal survival. However, the minimal subunit composition of gustatory receptors required for sensing aversive chemicals in Drosophila is unknown.
Jeong, Yong Taek +6 more
core +2 more sources
Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket and
Dean, I., Edwards, F.A., Robertson, S.J.
core +3 more sources