Results 41 to 50 of about 25,312 (210)
Effect of intrathecal glycine and related amino acids on the allodynia and hyperalgesic action of strychnine or bicuculline in mice [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundThe intrathecal (IT) administration of glycine or GABAA receptor antagonist result in a touch evoked allodynia through disinhibition in the spinal cord.
Eui Sung Lim, Il Ok Lee
doaj +1 more source
Pulse Programme Considerations for Quantitative NOE Analysis
Magnetic Resonance in Chemistry, EarlyView.NOESY and ROESY spectra are frequently used to obtain interatomic distances in solution. Here, the performance of six routinely used pulse programmes is evaluated, with the number of quantified correlations and the accuracy of the NOE‐based distances being used as the main assessment criteria. ABSTRACT Accurate NOE/ROE‐based distance determination is a
Lianne H. E. Wieske +2 more
wiley +1 more source
, 2016 A linear synthesis of the indole alkaloid (±)-akuammicine (2) was completed by a novel sequence of reactions requiring only 10 steps from commercially available starting materials.
Jane Betty Goh (2985018) +4 more
core +1 more source
Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes
Frontiers in Molecular Biosciences, 2018 The 25 human bitter taste receptors (hT2Rs) recognize thousands of structurally and chemically diverse bitter substances. The binding modes of human bitter taste receptors hT2R10 and hT2R46, which are responsible for strychnine recognition, were ...
Ava Yuan Xue +10 more
doaj +1 more source
PROTEOMICS, EarlyView.ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz +6 more
wiley +1 more source
Marine Drugs, 2011 Fish detect extremely low levels of marine toxins tetrodotoxin (TTX) and saxitoxin (STX) via the specialized gustatory receptor(s). Physiological and pharmacological studies show that receptor(s) for TTX and STX are distinct from those which detect ...
Toshiaki J. Hara
doaj +1 more source
Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review
Phytotherapy Research, EarlyView.ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley +1 more source