Results 51 to 60 of about 2,368 (175)

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

Disease Models & Mechanisms, 2016
By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification.
Oriol Calvete, Andrea Varro, D. Mark Pritchard, Alicia Barroso, Marta Oteo, Miguel Ángel Morcillo, Pierfrancesco Vargiu, Steven Dodd, Miriam Garcia, José Reyes, Sagrario Ortega, Javier Benitez   +11 more
doaj   +1 more source

Elusive Gastric Atrophy in Children: Diagnostic Pitfalls and a Stepwise Approach

Case Reports in Pediatrics, Volume 2026, Issue 1, 2026.
Atrophic gastritis is an autoimmune gastritis that is characterised by the production of antibodies to parietal cells and intrinsic factor of the stomach. It is uncommon in paediatrics, as a result, is not usually in the differential diagnosis. A boy in middle childhood presented with a history of auditory hallucinations and fatigue, his workup only ...
Nikita Rodenbach, Annette Venter, Alfonso Rodriguez-Herrera, Julia Duder, Eimear Lee, Nikhat Kaura   +5 more
wiley   +1 more source

Phytochemical Composition, Antioxidant Activity, Toxicity Profile, and Gastroprotective Effect of the Ethanolic Bark Extract of Ficus sycomorus

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Background Ficus sycomorus (F. sycomorus) is a medicinal plant traditionally used for treating various ailments. This study aimed to evaluate the phytochemical composition, antioxidant potential, toxicity profile, and antiulcer activity of ethanolic bark extract.
Shamseldein Koko Abouh Adam, Ahmed Saeed Kabbashi, Bashir Mohamed Ahmed, Amna Elhassan Hamad Mohammad, Munmun Bardhan   +4 more
wiley   +1 more source

Research advancements and evaluation of multifactor‐induced murine models for gastric cancer

Animal Models and Experimental Medicine, Volume 8, Issue 11, Page 1923-1934, November 2025.
Murine models for gastric cancer. Abstract As one of the most prevalent gastrointestinal malignancies in humans, gastric cancer (GC) is often detected at an advanced stage, resulting in a poor prognosis and ranking it the fifth leading cause of cancer‐related deaths.
Yiqing Wang, Liang Zhang, Weixu Feng, Wanfeng Liu, Xiangyang Xue, Shiyu Feng   +5 more
wiley   +1 more source

Gastric duplication complicated by hypergastrinemia: A case report

Journal of Pediatric Surgery Case Reports
Introduction: Gastrointestinal duplications are rare congenital anomalies that can occur anywhere throughout the intestinal tract. However, gastric duplication is very rare.
Kenki Yamagata, Masaru Mizuno, Mayako Morii, Ryo Watanabe, Chiaki Hatazawa, Hiroaki Yoshino   +5 more
doaj   +1 more source

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway

Frontiers in Cellular and Infection Microbiology, 2018
Helicobacter pylori is associated with hypergastrinemia, which has been linked to the development of gastric diseases. Although the molecular mechanism is not fully understood, H.
Niluka Gunawardhana, Niluka Gunawardhana, Sungil Jang, Yun Hui Choi, Youngmin A. Hong, Yeong-Eui Jeon, Aeryun Kim, Hanfu Su, Hanfu Su, Ji-Hye Kim, Yun-Jung Yoo, D. Scott Merrell, Jinmoon Kim, Jeong-Heon Cha, Jeong-Heon Cha   +14 more
doaj   +1 more source

Experimental correction of pathological changes in salivary glands by multiprobiotic Symbiter® acidofilus under conditions of hypergastrinemia

Current Issues in Pharmacy and Medical Sciences, 2010
Under conditions of long omeprazole introduction pathological changes in salivary glands tissues appear: intensification of free-radical oxidation, disbalance of proteolysis by decompensated type, increased activity of б-amilase, disbalance of ...
Andriy Sukhomlyn, Karine Neporada 
doaj  

A Prospective, Placebo‐Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats

Journal of Veterinary Internal Medicine, 2016
Background Chronic proton pump inhibitor administration has been associated with electrolyte and cobalamin deficiency, disrupted bone homeostasis, hypergastrinemia, and rebound acid hypersecretion in humans.
E. Gould, C. Clements, A. Reed, L. Giori, J.M. Steiner, J.A. Lidbury, J.S. Suchodolski, M. Brand, T. Moyers, L. Emery, M.K. Tolbert   +10 more
doaj   +1 more source

Paradoxically Augmented Anti-Tumorigenic Action of Proton Pump Inhibitor and Gastrin in APCMin/+ Intestinal Polyposis Model1

Neoplasia: An International Journal for Oncology Research, 2014
Though long-term administration of proton pump inhibitor (PPI) imposed the risk of gastrointestinal track tumorigenesis by accompanied hypergastrinemia, no overt increases of colon cancer risk were witnessed after a long-term cohort study.
Young-Min Han, Ki Baik Hahm, Jong-Min Park, Sung Pyo Hong, Eun-Hee Kim   +4 more
doaj   +1 more source

Evolution of clinical ideas about Zollinger-Ellison syndrome

Терапевтический архив, 2014
The paper gives the current views of the diagnosis and treatment of Zollinger-Ellison syndrome (ZES). It underlines the importance of including ZES in differential diagnosis in patient with frequently recurrent and standard-dose proton pump inhibitor ...
I V Maev, D N Andreev, Iu A Kucheriavyĭ, E V Barkalova   +3 more
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