Results 1 to 10 of about 54,552 (227)
Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways. [PDF]
PLoS ONEBackgroundPrevious studies have indicated elevated serum gastrin levels in individuals with HF. However, the association and underlying mechanisms between gastrin and HF remain unclear.
Yalu Du +7 more
doaj +2 more sources
Oral tolerogenic vaccine combined with gastrin restores immune tolerance and beta-cell function in NOD mice with Type 1 diabetes [PDF]
Frontiers in ImmunologyBackground and objectiveType 1 diabetes (T1D) results from autoimmune destruction of pancreatic β-cells. Current therapies fail to address the multiple mechanisms driving disease progression.
Jacob Cobb +4 more
doaj +2 more sources
The Lancet, 1965 The Lancet 285 (1965) 816-816.
University of Florida, Gainesville, United States. ( host institution ) +1 more
+6 more sources
Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis
Molecular Medicine, 2021 Background It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are increased in patients after myocardial infarction (MI).
Jinjuan Fu +5 more
doaj +1 more source
Gut, 1972 Gastrin release in the basal state and following a standard protein meal has been estimated in patients after partial gastrectomy, partial gastrectomy with truncal vagotomy, and total gastrectomy. Following partial gastrectomy, gastrin rose from 8 +/- 0.8 to 20 +/- 3.8 pg/ml with a protein meal. The rise in the partial gastrectomy with truncal vagotomy
M G, Korman, C, Soveny, J, Hansky
openaire +2 more sources
Gastrin: From Physiology to Gastrointestinal Malignancies
Function, 2022 Abetted by widespread usage of acid-suppressing proton pump inhibitors (PPIs), the mitogenic actions of the peptide hormone gastrin are being revisited as a recurring theme in various gastrointestinal (GI) malignancies.
Suzann Duan +2 more
doaj +1 more source
Gastrin, gastrin receptors and colorectal carcinoma [PDF]
Gut, 1998 The possibility that gastrin may play a role in the development of colorectal carcinoma has aroused considerable interest over the past decade. In early reports some colorectal carcinomas and colorectal carcinoma cell lines were shown to produce gastrin,1 to express gastrin receptors,2 and to respond mitogenically to exogenous gastrin.2 The most ...
G S, Baldwin, A, Shulkes
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NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells. [PDF]
PLoS ONE, 2013 The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the adenocarcinoma cell lines AR42J ...
Kristine Misund +9 more
doaj +1 more source
Interleukin-1β Suppresses Gastrin via Primary Cilia and Induces Antral HyperplasiaSummary
Cellular and Molecular Gastroenterology and Hepatology, 2021 Background & Aims: Helicobacter pylori infection in humans typically begins with colonization of the gastric antrum. The initial Th1 response occasionally coincides with an increase in gastrin secretion.
Lin Ding +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Ischemic/reperfusion (I/R) injury is the primary cause of acute kidney injury (AKI). Gastrin, a gastrointestinal hormone, is involved in the regulation of kidney function of sodium excretion. However, whether gastrin has an effect on kidney I/R injury is
Chao Liu +23 more
doaj +1 more source