Results 1 to 10 of about 29,877 (187)

Gastrin ameliorates heart failure and suppresses myocardial remodeling via the JAK2/STAT3 and ERK1/2 pathways. [PDF]

PLoS ONE
BackgroundPrevious studies have indicated elevated serum gastrin levels in individuals with HF. However, the association and underlying mechanisms between gastrin and HF remain unclear.
Yalu Du, Ning Wang, Jin Dong, Xiaohong Chai, Liang Liu, Haozhou Zhang, Bao Li, Jinjing Yang   +7 more
doaj   +2 more sources

Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis

Molecular Medicine, 2021
Background It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are increased in patients after myocardial infarction (MI).
Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue, Lin Cai   +5 more
doaj   +1 more source

Gastrin Attenuates Renal Ischemia/Reperfusion Injury by a PI3K/Akt/Bad-Mediated Anti-apoptosis Signaling

Frontiers in Pharmacology, 2020
Ischemic/reperfusion (I/R) injury is the primary cause of acute kidney injury (AKI). Gastrin, a gastrointestinal hormone, is involved in the regulation of kidney function of sodium excretion. However, whether gastrin has an effect on kidney I/R injury is
Chao Liu, Chao Liu, Ken Chen, Ken Chen, Huaixiang Wang, Ye Zhang, Ye Zhang, Xudong Duan, Yuanzheng Xue, Yuanzheng Xue, Hongye He, Hongye He, Yu Huang, Yu Huang, Zhi Chen, Zhi Chen, Hongmei Ren, Hongmei Ren, Hongyong Wang, Hongyong Wang, Chunyu Zeng, Chunyu Zeng, Chunyu Zeng, Chunyu Zeng   +23 more
doaj   +1 more source

Gastrin: From Physiology to Gastrointestinal Malignancies

Function, 2022
Abetted by widespread usage of acid-suppressing proton pump inhibitors (PPIs), the mitogenic actions of the peptide hormone gastrin are being revisited as a recurring theme in various gastrointestinal (GI) malignancies.
Suzann Duan, Karen Rico, Juanita L Merchant   +2 more
doaj   +1 more source

NR4A2 is regulated by gastrin and influences cellular responses of gastric adenocarcinoma cells. [PDF]

PLoS ONE, 2013
The peptide hormone gastrin is known to play a role in differentiation, growth and apoptosis of cells in the gastric mucosa. In this study we demonstrate that gastrin induces Nuclear Receptor 4A2 (NR4A2) expression in the adenocarcinoma cell lines AR42J ...
Kristine Misund, Linn-Karina Myrland Selvik, Shalini Rao, Kristin Nørsett, Ingunn Bakke, Arne K Sandvik, Astrid Lægreid, Torunn Bruland, Wenche S Prestvik, Liv Thommesen   +9 more
doaj   +1 more source

Interleukin-1β Suppresses Gastrin via Primary Cilia and Induces Antral HyperplasiaSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background & Aims: Helicobacter pylori infection in humans typically begins with colonization of the gastric antrum. The initial Th1 response occasionally coincides with an increase in gastrin secretion.
Lin Ding, Erica A. Sontz, Milena Saqui-Salces, Juanita L. Merchant   +3 more
doaj   +1 more source

Glycine-extended gastrin enhances somatostatin release from cultured rabbit fundic D-cells [v1; ref status: indexed, http://f1000r.es/8n]

F1000Research, 2013
The role of the peptide hormone gastrin in stimulating gastric acid secretion is well established. Mature amidated gastrin is processed from larger peptide precursor forms.
Ian LP Beales
doaj   +1 more source

Gastrin mediates cardioprotection through angiogenesis after myocardial infarction by activating the HIF-1α/VEGF signalling pathway

Scientific Reports, 2021
Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia–reperfusion injury.
Rui Wang, Ziyue Zhang, Zaicheng Xu, Na Wang, Dezhong Yang, Zhi Zhao Liu, Qiao Liao, Xuewei Xia, Caiyu Chen, Jialing Shou, Liangpeng Li, Wei Eric Wang, Chunyu Zeng, Tianyang Xia, Hongyong Wang   +14 more
doaj   +1 more source

Neuropeptide gastrin-releasing peptide induces PI3K/reactive oxygen species–dependent migration in lung adenocarcinoma cells

Tumor Biology, 2017
Nerve fibers and neurotransmitters have increasingly been shown to have a role in tumor progression. Gastrin-releasing peptide is a neuropeptide linked to tumor aggressiveness, acting as an autocrine tumor growth factor by binding to its receptor ...
Natália Jaeger, Rafael Sanguinetti Czepielewski, Maira Bagatini, Bárbara N Porto, Cristina Bonorino   +4 more
doaj   +1 more source

Analytical aspects of gastrin measurement in neuroendocrine tumors

Alʹmanah Kliničeskoj Mediciny, 2018
Rationale: Biochemical diagnostics of neuroendocrine tumors (NETs) is based on the analysis of universal and specific markers, according to the tumor type and clinical manifestations of the disease.
N. V. Lyubimova, T. K. Churikova, Yu. S. Timofeev, T. Yu. Kharitidy, N. E. Kushlinskii   +4 more
doaj   +1 more source