Results 21 to 30 of about 29,877 (187)

CCK‐1 and CCK‐2 receptor agonism do not stimulate GLP‐1 and neurotensin secretion in the isolated perfused rat small intestine or GLP‐1 and PYY secretion in the rat colon

Physiological Reports, 2020
Gastrin and cholecystokinin (CCK) are hormones released from endocrine cells in the antral stomach (gastrin), the duodenum, and the jejunum (CCK). Recent reports, based on secretion experiments in an enteroendocrine cell line (NCI‐H716) and gastrin ...
Ida M. Modvig, Charlotte B. Christiansen, Jens F. Rehfeld, Jens J. Holst, Simon Veedfald   +4 more
doaj   +1 more source

The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1. [PDF]

PLoS ONE, 2013
The hormone gastrin physiologically regulates gastric acid secretion and also contributes to maintaining gastric epithelial architecture by regulating expression of genes such as plasminogen activator inhibitor 2 (PAI-2) and regenerating protein 1 (Reg1).
Adrian O'Hara, Alice Howarth, Andrea Varro, Rod Dimaline   +3 more
doaj   +1 more source

Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro.

PLoS ONE, 2019
Gastrin is a peptide hormone, which in combination with other factors such as TGFα, EGF or GLP-1, is capable of increasing beta cell mass and lowering blood glucose levels in adult diabetic mice.
Ayelet Lenz, Gal Lenz, Hsun Teresa Ku, Kevin Ferreri, Fouad Kandeel   +4 more
doaj   +1 more source

Effects of Proton Pump Inhibitor Therapy, H. pylori Infection and Gastric Preneoplastic Pathology on Fasting Serum Gastrin Concentrations

Frontiers in Endocrinology, 2021
BackgroundHypergastrinaemia occasionally indicates the presence of a gastrinoma. However it is much more commonly associated with various benign causes including proton pump inhibitor (PPI) use, Helicobacter pylori infection and/or atrophic gastritis ...
Reuben Veysey-Smith, Andrew R. Moore, Andrew R. Moore, Senthil V. Murugesan, Senthil V. Murugesan, Laszlo Tiszlavicz, Graham J. Dockray, Andrea Varro, D. Mark Pritchard, D. Mark Pritchard   +9 more
doaj   +1 more source

Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway

Frontiers in Cellular and Infection Microbiology, 2018
Helicobacter pylori is associated with hypergastrinemia, which has been linked to the development of gastric diseases. Although the molecular mechanism is not fully understood, H.
Niluka Gunawardhana, Niluka Gunawardhana, Sungil Jang, Yun Hui Choi, Youngmin A. Hong, Yeong-Eui Jeon, Aeryun Kim, Hanfu Su, Hanfu Su, Ji-Hye Kim, Yun-Jung Yoo, D. Scott Merrell, Jinmoon Kim, Jeong-Heon Cha, Jeong-Heon Cha   +14 more
doaj   +1 more source

Clinical application of serological gastric biopsy in the screening of gastric precancerous disease

Zhongguo linchuang yanjiu, 2023
Objective To analyze the correlation between gastric mucosa serological biopsy ［serum pepsinogen Ⅰ（PGⅠ）, pepsinogen Ⅱ（PGⅡ）, ratio of PGⅠ/PGⅡ(PGR), gastrin-17 and helicobacter pyloriantibody（HP-IgG）］ and histological gastritis evaluation criteria （OLGA ...
DONG Wen-zhu*, LIANG Yue, ZHAO Qi, YU Hai-tao, LI Dong, CHEN Yan, WANG Qun-ying
doaj   +1 more source

Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling

BMC Cancer, 2018
Background Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, but how its function affects ...
Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han, Guo-Hui Fu   +7 more
doaj   +1 more source

Gastrin, Cholecystokinin, Signaling, and Biological Activities in Cellular Processes

Frontiers in Endocrinology, 2020
The structurally-related peptides, gastrin and cholecystokinin (CCK), were originally discovered as humoral stimulants of gastric acid secretion and pancreatic enzyme release, respectively.
Qiang Zeng, Lei Ou, Wei Wang, Dong-Yu Guo   +3 more
doaj   +1 more source

Radioimmunoassay of gastrin

Gastroenterology, 1970
Summary A highly specific radioimmunoassay for endogenous human plasma gastrin was developed using guinea pig antisera to crude porcine gastrin. Highly purified 125 I-porcine gastrin I, further purified on starch gel electrophoresis after labeling, was employed as tracer, and an anionic exchange resin was used to separate bound and free labeled ...
R S, Yalow, S A, Berson
openaire   +2 more sources

Gastrin signaling in cardiovascular pathophysiology: From molecular crosstalk to clinical implications

Clinical and Experimental Hypertension
As a gastrointestinal hormone, gastrin stimulates gastric acid secretion and intestinal mucosal nutrition. Evidence links it closely to coronary heart disease, ischemia‒reperfusion injury and hypertension.
Chunmei Xu, Zhuxin Li, Yongchun Zeng, Hao Luo, Xuewei Xia   +4 more
doaj   +1 more source