Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. [PDF]
, 1992 Helicobacter pylori increases gastrin release in duodenal ulcer patients. This may be through disruption or changes in the mucus layer affecting the access of luminal stimulants to gastrin releasing cells.
Ghosh, P +6 more
core +5 more sources
Clinical Outcomes of Antrectomy for Patients With Multiple Type I Gastric Neuroendocrine Tumors: A Case Series. [PDF]
DEN OpenType I gastric neuroendocrine tumors (T1‑GNETs) often present as multiple lesions, complicating treatment. This retrospective case series study evaluates antrectomy outcomes in eight patients with persistent multiple T1‑GNETs during 2005–2023. Following antrectomy, tumor regression was observed in two patients and complete disappearance in six, with ...
Morita Y +9 more
europepmc +2 more sources
Gastrin and Gastrin Receptors in Colorectal Neoplasia [PDF]
, 1995 Colorectal cancer remains a common public health issue and a leading cause of mortality in the industrialised world. Much still needs to be learned about the factors regulating the proliferation of colonic epithelial cells but a large body of work ...
Penman, Ian Douglas
core +6 more sources
Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm. [PDF]
CytopathologyIntracytoplasmic inclusions observed in rhabdoid‐type neuroendocrine tumours are evident on Giemsa staining and show strong cytokeratin (AE1/AE3) positivity on immunocytochemistry. This report describes the cytological features of a rare rhabdoid variant of pancreatic neuroendocrine neoplasm and highlights the diagnostic challenges associated with this
Okuda M +4 more
europepmc +2 more sources
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Scientific Reports, 2021 Acute myocardial infarction (MI) is one of the leading causes of death in humans. Our previous studies showed that gastrin alleviated acute myocardial ischaemia–reperfusion injury.
Rui Wang +14 more
doaj +1 more source
Tumor Biology, 2017 Nerve fibers and neurotransmitters have increasingly been shown to have a role in tumor progression. Gastrin-releasing peptide is a neuropeptide linked to tumor aggressiveness, acting as an autocrine tumor growth factor by binding to its receptor ...
Natália Jaeger +4 more
doaj +1 more source
Development and analytical performance evaluation of an automated chemiluminescent immunoassay for pro-gastrin releasing peptide (ProGRP) [PDF]
, 2009 Background: Pro-gastrin releasing peptide ( ProGRP) concentrations in blood play an important role in the diagnosis and treatment of patients with small cell lung cancer (SCLC).
Patil, Rahul D. +17 more
core +1 more source
17Beta-estradiol modulates gastroduodenal preneoplastic alterations in rats exposed to the carcinogen N-methyl-N'-nitro-nitrosoguanidine [PDF]
, 1999 Gastric cancers are a significant cause of morbidity worldwide. Epidemiological studies and animal models show that males have higher incidences of gastric cancers compared with females, suggesting that sex hormones may modulate gastric cancer risk.
Reyher, K K +4 more
core +1 more source
Analytical aspects of gastrin measurement in neuroendocrine tumors
Alʹmanah Kliničeskoj Mediciny, 2018 Rationale: Biochemical diagnostics of neuroendocrine tumors (NETs) is based on the analysis of universal and specific markers, according to the tumor type and clinical manifestations of the disease.
N. V. Lyubimova +4 more
doaj +1 more source