Results 1 to 10 of about 254,157 (265)
A compendium of ERK targets [PDF]
FEBS Letters, 2017 The RAF‐MEK‐ERK cascade is one of the most studied signaling pathways as it controls many vital cellular programs. There has been an immense amount of effort to determine ERK target proteins involved in regulating these programs. Classical biochemical and genetic approaches have elicited hundreds of direct ERK substrates, and with the advent of phospho‐
Florian Uhlitz, Nils Bluthgen
exaly +3 more sources
The effect of high-intensity interval swimming training on CREB and ERK proteins of hippocampus tissue in elderly rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: Cognitive impairment caused by aging has become one of the most common health threats in many countries. Signaling pathways are important moderators of various physiological and pathological processes, and abnormal activation of ...
Zahra Sabri, Mozhgan Ahmadi
doaj +1 more source
Anti-tumor mechanism of evodiamine on gastric cancer cells in vitro through MAPK signaling pathway
Di-san junyi daxue xuebao, 2021 Objective To investigate the anti-tumor effect of evodiamine on gastric cancer cells via the MAPK signaling pathway. Methods MTT assay was used to assess the cell viability of SGC-7901 cells after the treatment of 8, 16 and 32 μmol/L evocarpine (denoted ...
QIAN Weina +4 more
doaj +1 more source
Di-san junyi daxue xuebao, 2021 Objective To investigate the effects of oncostatin M (OSM) on the proliferation and extracellular matrix secretion of human dermal fibroblasts (HDFs) in high glucose environment and its possible mechanism.
LIU Lulu, FU Xueming, XUE Biyu, XUE Bin
doaj +1 more source
Autoimmunity, 2022 Rheumatoid arthritis is troublesome to treat effectively and often requires concomitant long-term treatment. Meanwhile, synovial fibroblasts could induce inflammation response and lead to joint erosion, finally causing progressive joint destruction ...
Jun Liu +7 more
doaj +1 more source
Di-san junyi daxue xuebao, 2021 Objective To investigate the anti-tumor effect of sorafenib (Sor) combined with Ophiopogonin D'(OPD') on androgen-independent prostate cancer (PC3) cells and its mechanism.
ZHANG Yaowen +3 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: The mortality rate of colorectal cancer (CRC) ranks second worldwide. Previous research had indicated that licochalcone A (LA) was a flavonoid in licorice with diverse anticancer effects.
Tianpeng Li +11 more
doaj +1 more source
Identification of sphingosine 1-phosphate level and MAPK/ERK signaling in pancreatic β cells [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2021 Purpose Sphingosine kinase is a lipid kinase that phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). S1P regulates pancreatic islet β-cell endoplasmic reticulum stress and proliferation.
Ji Hyun Park +3 more
doaj +1 more source
IEX‐1: a new ERK substrate involved in both ERK survival activity and ERK activation [PDF]
The EMBO Journal, 2002 IEX-1 is an early response and NF-kappaB target gene implicated in the regulation of cellular viability. We show here that IEX-1 is a substrate for ERKs and that IEX-1 and ERK regulate each other's activities. IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation.
Josefina, Garcia +5 more
openaire +2 more sources
Journal of Signal Transduction, 2011 Acute or chronic kidney injury results from various insults and pathological conditions, and is accompanied by activation of compensatory repair mechanisms. Both insults and repair mechanisms are initiated by circulating factors, whose cellular effects are mediated by activation selective signal transduction pathways.
Feliers, Denis +1 more
openaire +2 more sources