Results 1 to 10 of about 177,354 (301)
Selective Inhibitors for JNK Signalling: A Potential Targeted Therapy in Cancer
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer.
Vesna Jacevic, Xu Wang, Kamil Kuča
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INFLUENCE OF AN INHIBITOR OF JNK ON THE SECRETION OF THE INFLAMMASOME–DEPENDENT PROINFLAMMATORY CYTOKINES [PDF]
Journal of IMAB, 2020 Purpose: In this study, we determine the influence of prolonged exposure on organic air pollutants, on the secretion of inflammasome-dependent cytokines IL-1β and IL-18.
Boncho Grigorov +3 more
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Autophagy Reports, 2023 During organogenesis cellular homeostasis plays a crucial role in patterning and growth. The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of several developmental genes by GAGA factor or Motif 1 Binding Protein ...
Anuradha Venkatakrishnan Chimata +4 more
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Disease Models & Mechanisms, 2021 The mammalian central nervous system (CNS) exhibits limited regenerative capacity and the mechanisms that mediate its regeneration are not fully understood.
María Losada-Pérez +2 more
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The expression of MAPK signaling pathways in conjunctivochalasis [PDF]
International Journal of Ophthalmology, 2019 This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis (CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls (CON) were collected.
Yuan-Ling Jia +4 more
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Spz/Toll-6 signal guides organotropic metastasis in Drosophila
Disease Models & Mechanisms, 2019 Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model to study developmental and cancer biology.
Ketu Mishra-Gorur +5 more
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Impact of JNK and Its Substrates on Dendritic Spine Morphology
Cells, 2020 The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins.
Emilia Komulainen +6 more
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Biomolecules, 2019 Lead (Pb) is a toxic heavy metal pollutant with adverse effects on the liver and other body organs. Curcumin (CUR) is the principal curcuminoid of turmeric and possesses strong antioxidant and anti-inflammatory activities.
Ahlam Alhusaini +5 more
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Cancer Biology & Medicine, 2022 Objective: Protein convertase subtilisin/Kexin type 9 (PCSK9) has been found to be closely associated with the occurrence and development of numerous tumors.
Mingyan He +6 more
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Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years.
Yoo Jin Na +5 more
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