Results 11 to 20 of about 164,331 (306)
Regulation of JNK signaling by GSTp [PDF]
EMBO Journal, 1999 Studies of low basal Jun N-terminal kinase (JNK) activity in non-stressed cells led us to identify a JNK inhibitor that was purified and identified as glutathione S-transferase Pi (GSTp) and was characterized as a JNK-associated protein. UV irradiation or H2O2 treatment caused GSTp oligomerization and dissociation of the GSTp-JNK complex, indicating ...
VÍCTOR Adler +2 more
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JNK Pathway in CNS Pathologies [PDF]
International Journal of Molecular Sciences, 2021 The c-Jun N-terminal Kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals. Besides the stress response, the JNK pathway is involved in a series of vital regulatory mechanisms during development and adulthood that are critical to maintain tissue homeostasis. These mechanisms include the
Teresa de los Reyes Corrales +2 more
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Bistability in the JNK cascade [PDF]
Current Biology, 2001 Important signaling properties, like adaptation, oscillations, and bistability, can emerge at the level of relatively simple systems of signaling proteins. Here, we have examined the quantitative properties of one well-studied signaling system, the JNK cascade.
Bagowski, Christoph P, Ferrell, James E
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Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids [PDF]
The EMBO Journal, 2003 Inhibition of the c-Jun N-terminal kinase (JNK) pathway by glucocorticoids (GCs) results in AP-1 repression. GC antagonism of AP-1 relies mainly on the transrepression function of the GC receptor (GR) and mediates essential physiological and pharmacological actions.
Alejandra, Bruna +4 more
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Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 c-Jun N-terminal kinase (JNK) signalling regulates both cancer cell apoptosis and survival. Emerging evidence show that JNK promoted tumour progression is involved in various cancers, that include human pancreatic-, lung-, and breast cancer.
Qinghua Wu, Wenda Wu, Vesna Jacevic
exaly +2 more sources
Role of JNK in Tumor Development [PDF]
Cell Cycle, 2003 The c-Jun NH2-terminal kinase (JNK) is implicated in oncogenic transformation. However, studies of the effect of Jnk gene disruption on Ras-induced transformation of murine fibroblasts indicate that JNK may act as a suppressor of Ras transformation and that the JNK signaling pathway contributes to the apoptotic elimination of transformed cells in vivo.
Kennedy, Norman J., Davis, Roger J.
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Identification of a new JNK inhibitor targeting the JNK-JIP interaction site [PDF]
Proceedings of the National Academy of Sciences, 2008 JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states. JNK-interacting protein-1 (JIP1) is a scaffolding protein that enhances JNK signaling by creating a proximity effect between JNK and upstream kinases. A minimal peptide region derived from JIP1 is able to inhibit JNK activity
John L, Stebbins +12 more
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INFLUENCE OF AN INHIBITOR OF JNK ON THE SECRETION OF THE INFLAMMASOME–DEPENDENT PROINFLAMMATORY CYTOKINES [PDF]
Journal of IMAB, 2020 Purpose: In this study, we determine the influence of prolonged exposure on organic air pollutants, on the secretion of inflammasome-dependent cytokines IL-1β and IL-18.
Boncho Grigorov +3 more
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Autophagy Reports, 2023 During organogenesis cellular homeostasis plays a crucial role in patterning and growth. The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of several developmental genes by GAGA factor or Motif 1 Binding Protein ...
Anuradha Venkatakrishnan Chimata +4 more
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Disease Models & Mechanisms, 2021 The mammalian central nervous system (CNS) exhibits limited regenerative capacity and the mechanisms that mediate its regeneration are not fully understood.
María Losada-Pérez +2 more
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