Results 11 to 20 of about 167,128 (299)
Bistability in the JNK cascade [PDF]
Current Biology, 2001 Important signaling properties, like adaptation, oscillations, and bistability, can emerge at the level of relatively simple systems of signaling proteins. Here, we have examined the quantitative properties of one well-studied signaling system, the JNK cascade.
Bagowski, Christoph P, Ferrell, James E
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Glucocorticoid receptor–JNK interaction mediates inhibition of the JNK pathway by glucocorticoids [PDF]
The EMBO Journal, 2003 Inhibition of the c-Jun N-terminal kinase (JNK) pathway by glucocorticoids (GCs) results in AP-1 repression. GC antagonism of AP-1 relies mainly on the transrepression function of the GC receptor (GR) and mediates essential physiological and pharmacological actions.
Alejandra, Bruna +4 more
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Role of JNK in Tumor Development [PDF]
Cell Cycle, 2003 The c-Jun NH2-terminal kinase (JNK) is implicated in oncogenic transformation. However, studies of the effect of Jnk gene disruption on Ras-induced transformation of murine fibroblasts indicate that JNK may act as a suppressor of Ras transformation and that the JNK signaling pathway contributes to the apoptotic elimination of transformed cells in vivo.
Kennedy, Norman J., Davis, Roger J.
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JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]
, 2014 Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Concetta Bubici +3 more
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Biomolecules, 2019 Lead (Pb) is a toxic heavy metal pollutant with adverse effects on the liver and other body organs. Curcumin (CUR) is the principal curcuminoid of turmeric and possesses strong antioxidant and anti-inflammatory activities.
Ahlam Alhusaini +5 more
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Cancer Biology & Medicine, 2022 Objective: Protein convertase subtilisin/Kexin type 9 (PCSK9) has been found to be closely associated with the occurrence and development of numerous tumors.
Mingyan He +6 more
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Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years.
Yoo Jin Na +5 more
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MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways [PDF]
, 2010 MafB is a basic leucine zipper transcription factor that plays important roles in development and differentiation processes. During osteoclastogenesis, its expression is downregulated at the transcriptional level via the JNK and p38 MAP kinase pathways ...
Ito, Takashi +3 more
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INVOLVEMENT OF JNK MAPK CASCADES IN THE FORMATION OF ADHESIONS IN THE ABDOMINAL CAVITY
Acta Biomedica Scientifica, 2018 Adhesive process in the abdominal cavity is one of the most frequent complications of intra-abdominal surgery.The aim of the study was to evaluate the activation of the JNK MAPK cascade during the experimental adhesion process.Materials and methods ...
I. A. Shurygina +4 more
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The functional contrariety of JNK [PDF]
Molecular Carcinogenesis, 2007 AbstractThe JNK proteins are activated by multiple and diverse stimuli, leading to varied and seemingly contradictory cellular responses. In particular, JNKs have been reported to have a role in the induction of apoptosis, but have also been implicated in enhancing cell survival and proliferation. Thus the JNK proteins seem to represent an archetype of
Ann M, Bode, Zigang, Dong
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