Results 11 to 20 of about 177,354 (301)
Glucocorticoid receptor–JNK interaction mediates inhibition of the JNK pathway by glucocorticoids [PDF]
The EMBO Journal, 2003 Inhibition of the c-Jun N-terminal kinase (JNK) pathway by glucocorticoids (GCs) results in AP-1 repression. GC antagonism of AP-1 relies mainly on the transrepression function of the GC receptor (GR) and mediates essential physiological and pharmacological actions.
Alejandra, Bruna +4 more
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Role of JNK in Tumor Development [PDF]
Cell Cycle, 2003 The c-Jun NH2-terminal kinase (JNK) is implicated in oncogenic transformation. However, studies of the effect of Jnk gene disruption on Ras-induced transformation of murine fibroblasts indicate that JNK may act as a suppressor of Ras transformation and that the JNK signaling pathway contributes to the apoptotic elimination of transformed cells in vivo.
Kennedy, Norman J., Davis, Roger J.
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Periostin-CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy. [PDF]
Adv Sci (Weinh)POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Wu T +12 more
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JNK Pathway in CNS Pathologies [PDF]
International Journal of Molecular Sciences, 2021 The c-Jun N-terminal Kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals. Besides the stress response, the JNK pathway is involved in a series of vital regulatory mechanisms during development and adulthood that are critical to maintain tissue homeostasis. These mechanisms include the
Teresa de los Reyes Corrales +2 more
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Recruitment of JNK to JIP1 and JNK-dependent JIP1 Phosphorylation Regulates JNK Module Dynamics and Activation [PDF]
Journal of Biological Chemistry, 2003 JIP1 is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase-dependent JNK module. Results of earlier work led us to propose a model for JIP1-JNK complex regulation that predicts that under basal conditions, JIP1 maintains DLK in a monomeric, unphosphorylated, and catalytically inactive state.
Deepak, Nihalani +2 more
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JNK and cardiometabolic dysfunction [PDF]
Bioscience Reports, 2019 Abstract Cardiometabolic syndrome (CMS) describes the cluster of metabolic and cardiovascular diseases that are generally characterized by impaired glucose tolerance, intra-abdominal adiposity, dyslipidemia, and hypertension. CMS currently affects more than 25% of the world’s population and the rates of diseases are rapidly rising. These
Siobhan M. Craige +4 more
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JNK signaling in apoptosis [PDF]
Oncogene, 2008 Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and ...
D N, Dhanasekaran, E P, Reddy
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JNK signalling in cancer: In need of new, smarter therapeutic targets [PDF]
, 2014 Copyright © 2013 The British Pharmacological Society. This is the accepted version of the following article: Bubici, C. and Papa, S. (2014), JNK signalling in cancer: in need of new, smarter therapeutic targets.
Concetta Bubici +3 more
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MafB protein stability is regulated by the JNK and ubiquitin-proteasome pathways [PDF]
, 2010 MafB is a basic leucine zipper transcription factor that plays important roles in development and differentiation processes. During osteoclastogenesis, its expression is downregulated at the transcriptional level via the JNK and p38 MAP kinase pathways ...
Ito, Takashi +3 more
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Bistability in the JNK cascade [PDF]
Current Biology, 2001 Important signaling properties, like adaptation, oscillations, and bistability, can emerge at the level of relatively simple systems of signaling proteins. Here, we have examined the quantitative properties of one well-studied signaling system, the JNK cascade.
Bagowski, Christoph P, Ferrell, James E
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