Mitogen-Activated Protein Kinases: Therapeutic Signaling Catalysts in Viral Immune Evasion [PDF]
PathogensThe mitogen-activated protein kinase (MAPK) pathways, ERK, JNK, and p38, are key regulators of immune responses during viral infections. These signaling cascades control cytokine production, T cell activity, and antigen presentation.
Masood Alam Khan +2 more
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Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs) [PDF]
BiomoleculesProbenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones +4 more
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Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link [PDF]
Cells, 2019 In recent years, the incidence of both liver and biliary tract cancer has increased. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the two most common types of hepatic malignancies.
Chaobo Chen +3 more
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Editorial: Mitogen Activated Protein Kinases [PDF]
Frontiers in Cell and Developmental Biology, 2017 Ana Cuenda +2 more
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Evolutionary history of the vertebrate mitogen activated protein kinases family. [PDF]
PLoS ONE, 2011 BackgroundThe mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cellular processes and pathways essential to most organisms. Its evolution is conserved throughout the eukaryotic kingdoms.
Meng Li, Jun Liu, Chiyu Zhang
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Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks
Frontiers in Plant Science, 2020 Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan +3 more
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MAPK immunoreactivity in streptozotocin-induced diabetic rat testis [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes.
Yelız Bozdemır Donmez +2 more
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Thrombomodulin Regulation of Mitogen-Activated Protein Kinases [PDF]
International Journal of Molecular Sciences, 2019 Hemant Giri +2 more
exaly +2 more sources
Cellular reprogramming through mitogen-activated protein kinases
Frontiers in Plant Science, 2015 Mitogen-activated protein kinase (MAPK) cascades are conserved eukaryote signaling modules where MAPKs, as the final kinases in the cascade, phosphorylate protein substrates to regulate cellular processes.
Justin eLee +7 more
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Mitogen-Activated Protein Kinases and Hypoxic/Ischemic Nephropathy
Cellular Physiology and Biochemistry, 2016 Tissue hypoxia/ischemia is a pathological feature of many human disorders including stroke, myocardial infarction, hypoxic/ischemic nephropathy, as well as cancer.
Fengbao Luo +5 more
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