Results 1 to 10 of about 257 (183)

The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis

Brazilian Journal of Oncology, 2022
Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflicting results. We
Mauricio Fernando Silva Almeida Ribeiro, Camila Bragança Xavier, Allan Andresson Lima Pereira, Mariana Scaranti, Luiza Dib Batista Bugiato Faria, Tatiana Strava Correa, Marina Sahade, David Queiroz Borges Muniz, Olavo Feher, Gustavo dos Santos Fernandes, Artur Katz, Rodrigo Ramella Munhoz   +11 more
doaj   +1 more source

Expression of Sprouty 2 in cutaneous squamous cell carcinoma and its relationship with E-cadherin and Ki-67

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To detect the expression and localization of Sprouty 2, E-cadherin (E-cad) and Ki-67 in skin tissue of squamous cell carcinoma (CSCC), and to analyze the correlation of Sprouty 2 with E-cad and Ki-67.
Chao LI, Wei ZHONG, Lei ZHU, Yuqi HUANG, Jinyi LI, Yongfeng CHEN   +5 more
doaj   +1 more source

Sonic Hedgehog Signaling in Thyroid Cancer

Frontiers in Endocrinology, 2017
Thyroid cancer is the most common malignancy of the endocrine system. The initiation of thyroid cancer is often triggered by a genetic mutation in the phosphortidylinositol-3 kinase (PI3K) or mitogen-activated protein kinase (MAPK) pathway, such as RAS ...
Xiulong Xu, Xiulong Xu, Yurong Lu, Yi Li, Richard A. Prinz   +4 more
doaj   +1 more source

HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients

Cell Reports, 2017
Summary: Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases.
Zhaobo Li, Lihong Zhou, Chrisostomos Prodromou, Velibor Savic, Laurence H. Pearl   +4 more
doaj   +1 more source

Salmonella Typhimurium type III secretion effectors stimulate innate immune responses in cultured epithelial cells. [PDF]

PLoS Pathogens, 2009
Recognition of conserved bacterial products by innate immune receptors leads to inflammatory responses that control pathogen spread but that can also result in pathology.
Vincent M Bruno, Sebastian Hannemann, María Lara-Tejero, Richard A Flavell, Steven H Kleinstein, Jorge E Galán   +5 more
doaj   +1 more source

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature

Cell Reports, 2015
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect the epigenetic regulatory machinery and signaling molecules, leading to a block in hematopoietic differentiation. Constitutive signaling from mutated growth factor receptors
Pierre Cauchy, Sally R. James, Joaquin Zacarias-Cabeza, Anetta Ptasinska, Maria Rosaria Imperato, Salam A. Assi, Jason Piper, Martina Canestraro, Maarten Hoogenkamp, Manoj Raghavan, Justin Loke, Susanna Akiki, Samuel J. Clokie, Stephen J. Richards, David R. Westhead, Michael J. Griffiths, Sascha Ott, Constanze Bonifer, Peter N. Cockerill   +18 more
doaj   +1 more source

ERK5 and cell proliferation: nuclear localization is what matters

Frontiers in Cell and Developmental Biology, 2016
ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell ...
Nestor Gomez, Tatiana Erazo, Jose M Lizcano   +2 more
doaj   +1 more source

A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. [PDF]

PLoS Pathogens, 2011
Parasitic worms alter their host's immune system to diminish the inflammatory responses directed against them, using very efficient immunomodulating molecules.
Christian Klotz, Thomas Ziegler, Ana Sofia Figueiredo, Sebastian Rausch, Matthew R Hepworth, Nadja Obsivac, Christine Sers, Roland Lang, Peter Hammerstein, Richard Lucius, Susanne Hartmann   +10 more
doaj   +1 more source

Effect of IL-33 on pyroptosis of macrophages in mice with sepsis via NF-κB/p38 MAPK signaling pathway

Acta Cirúrgica Brasileira, 2021
Purpose To demonstrate the effect of IL-33 on the macrophage pyroptosis in mice with sepsis through the NF-kB/p38 MAPK signal pathway. Methods In total, 24 C57BL/6 mice were divided into the sham operation group (sham) and the cecal ligation and ...
Jingnuan Ke, Guolong Cai
doaj   +1 more source

Anti-cancer therapeutic strategies based on HGF/MET, EpCAM, and tumor-stromal cross talk

Cancer Cell International, 2022
As an intelligent disease, tumors apply several pathways to evade the immune system. It can use alternative routes to bypass intracellular signaling pathways, such as nuclear factor-κB (NF-κB), Wnt, and mitogen-activated protein (MAP)/phosphoinositide 3 ...
Khadijeh Barzaman, Rana Vafaei, Mitra Samadi, Mohammad Hossein Kazemi, Aysooda Hosseinzadeh, Parnaz Merikhian, Shima Moradi-Kalbolandi, Mohammad Reza Eisavand, Houra Dinvari, Leila Farahmand   +9 more
doaj   +1 more source