Auditory Fear Conditioning and Long-Term Potentiation in the Lateral Amygdala Require ERK/MAP Kinase Signaling in the Auditory Thalamus: A Role for Presynaptic Plasticity in the Fear System [PDF]
Journal of Neuroscience, 2005 In the present study, we examined the role of the auditory thalamus [medial division of the medial geniculate nucleus and the adjacent posterior intralaminar nucleus (MGm/PIN)] in auditory pavlovian fear conditioning using pharmacological manipulation of intracellular signaling pathways.
Apergis-Schoute, Annemieke M +4 more
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Regulation of peripheral inflammation by spinal p38 MAP kinase in rats. [PDF]
PLoS Medicine, 2006 Somatic afferent input to the spinal cord from a peripheral inflammatory site can modulate the peripheral response. However, the intracellular signaling mechanisms in the spinal cord that regulate this linkage have not been defined.
David L Boyle +7 more
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Postsynaptic localization of PSD-95 is regulated by all three pathways downstream of TrkB signaling
Frontiers in Synaptic Neuroscience, 2014 BDNF and its receptor TrkB regulate synaptic plasticity. TrkB triggers three downstream signaling pathways; Phosphatidylinositol 3-kinase (PI3K), Phospholipase Cγ (PLC γ) and Mitogen activated protein kinases/ Extracellular signal-regulated kinases (MAPK/
Akira eYoshii, Martha eConstantine-Paton
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The Xanthomonas euvesicatoria type III effector XopAU is an active protein kinase that manipulates plant MAP kinase signaling. [PDF]
PLoS Pathogens, 2018 The Gram-negative bacterium Xanthomonas euvesicatoria (Xe) is the causal agent of bacterial spot disease of pepper and tomato. Xe delivers effector proteins into host cells through the type III secretion system to promote disease.
Doron Teper +5 more
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Seminars in Cell & Developmental Biology, 2011 Understanding the mechanisms of drug action has been the primary focus for pharmacological researchers, traditionally using rodent models. However, non-sentient model systems are now increasingly being used as an alternative approach to better understand drug action or targets.
Ludtmann, Marthe H.R. +2 more
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The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory [PDF]
Journal of Neurochemistry, 2001 The mitogen‐activated protein kinase (MAP kinase, MAPK) cascade, as the name implies, was originally discovered as a critical regulator of cell division and differentiation. As further details of this signaling cascade were worked out, it became clear that the MAPK cascade is in fact a prototype for a family of signaling cascades that share the motif ...
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BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
PLoS ONE, 2008 Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking.
Joseph H Jeong +14 more
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Astaxanthin alleviates autophagy, inflammation, and oxidative stress in ventilator-associated lung injury rats by inhibiting MAPK/ERK1/2 pathway [PDF]
Acta Cirúrgica BrasileiraPurpose: Improper use of mechanical ventilation may result in ventilator-induced lung injury (VILI). This work seeks to explore the preventive impact of astaxanthin on VILI. Methods: In this study, we established the VILI rat and drug intervention model,
Jiayi Zhang +6 more
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Molecules, 2021 RET (rearranged during transfection) kinase, one of the receptor tyrosine kinases, plays a crucial role in the development of the human nervous system.
Swapnil P. Bhujbal +2 more
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Frontiers in Psychiatry, 2013 Chronic cocaine administration regulates the expression of several proteins related to dopaminergic signaling and synaptic function in the mesocorticolimbic pathway, including the prefrontal cortex.
Scot eMcIntosh +3 more
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