Results 21 to 30 of about 179,821 (233)

Interaction Analysis of a Two-Component System Using Nanodiscs. [PDF]

PLoS ONE, 2016
Two-component systems are the major means by which bacteria couple adaptation to environmental changes. All utilize a phosphorylation cascade from a histidine kinase to a response regulator, and some also employ an accessory protein.
Patrick Hörnschemeyer, Viktoria Liss, Ralf Heermann, Kirsten Jung, Sabine Hunke   +4 more
doaj   +1 more source

Inhibition of MEK1/2 Signaling Pathway Limits M2 Macrophage Polarization and Interferes in the Dental Socket Repair Process in Mice

Biology
Dental socket repair theoretically involves a constructive inflammatory immune response, which evolves from an initial M1 prevalence to a subsequent M2 dominance.
Angélica Cristina Fonseca, Priscila Maria Colavite, Michelle de Campos Soriani Azevedo, Daniela Carignatto Passadori, Jessica Lima Melchiades, Rafael Carneiro Ortiz, Camila Oliveira Rodini, Ana Paula Favaro Trombone, Gustavo Pompermaier Garlet   +8 more
doaj   +1 more source

Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.

PLoS Genetics, 2012
The ability to perceive noxious stimuli is critical for an animal's survival in the face of environmental danger, and thus pain perception is likely to be under stringent evolutionary pressure.
G Gregory Neely, Shuan Rao, Michael Costigan, Norbert Mair, Ildiko Racz, Giedre Milinkeviciute, Arabella Meixner, Swetha Nayanala, Robert S Griffin, Inna Belfer, Feng Dai, Shad Smith, Luda Diatchenko, Stefano Marengo, Bernhard J Haubner, Maria Novatchkova, Dustin Gibson, William Maixner, J Andrew Pospisilik, Emilio Hirsch, Ian Q Whishaw, Andreas Zimmer, Vaijayanti Gupta, Junko Sasaki, Yasunori Kanaho, Takehiko Sasaki, Michaela Kress, Clifford J Woolf, Josef M Penninger   +28 more
doaj   +1 more source

Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

Antioxidants, 2021
ROS (reactive oxygen species) are produced via the noncomplete reduction in molecular oxygen in the mitochondria of higher organisms. The produced ROS are placed in various cell compartments, such as the mitochondria, cytoplasm, and endoplasmic reticulum.
Abdelhakim Bouyahya, Naoual El Menyiy, Loubna Oumeslakht, Aicha El Allam, Abdelaali Balahbib, Abdur Rauf, Naveed Muhammad, Elena Kuznetsova, Marina Derkho, Muthu Thiruvengadam, Mohammad Ali Shariati, Nasreddine El Omari   +11 more
doaj   +1 more source

Single-Cell Analysis of the Neonatal Immune System Across the Gestational Age Continuum

Frontiers in Immunology, 2021
Although most causes of death and morbidity in premature infants are related to immune maladaptation, the premature immune system remains poorly understood.
Laura S. Peterson, Julien Hedou, Edward A. Ganio, Ina A. Stelzer, Dorien Feyaerts, Eliza Harbert, Yamini Adusumelli, Kazuo Ando, Eileen S. Tsai, Amy S. Tsai, Xiaoyuan Han, Megan Ringle, Pearl Houghteling, Jonathan D. Reiss, David B. Lewis, Virginia D. Winn, Martin S. Angst, Nima Aghaeepour, Nima Aghaeepour, Nima Aghaeepour, David K. Stevenson, Brice Gaudilliere, Brice Gaudilliere   +22 more
doaj   +1 more source

Electroacupuncture at the Dazhui and Baihui acupoints and different frequencies (10 and 50 Hz) protects against apoptosis by up-regulating ERK1/2-mediated signaling in rats after global cerebral ischemia [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study assessed the effects of electroacupuncture (EA) stimulation at different frequencies at the Dazhui and Baihui acupoints in the subacute phase after transient global cerebral ischemia (GCI).
Yueh-Ting Tsai, Chin-Yi Cheng
doaj   +1 more source

N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice

Frontiers in Molecular Neuroscience, 2018
N-methyl-D-aspartate receptors (NMDARs) respond to glutamate to allow the influx of calcium ions and the signaling to the mitogen-activated protein kinase (MAPK) cascade.
Rafael Franco, Rafael Franco, David Aguinaga, David Aguinaga, Irene Reyes, Irene Reyes, Enric I. Canela, Enric I. Canela, Jaume Lillo, Airi Tarutani, Masato Hasegawa, Anna del Ser-Badia, Anna del Ser-Badia, José A. del Rio, José A. del Rio, José A. del Rio, Michael R. Kreutz, Michael R. Kreutz, Carlos A. Saura, Carlos A. Saura, Gemma Navarro, Gemma Navarro   +21 more
doaj   +1 more source

Stress Activated MAP Kinases and Cyclin-Dependent Kinase 5 Mediate Nuclear Translocation of Nrf2 via Hsp90α-Pin1-Dynein Motor Transport Machinery

Antioxidants, 2023
Non-lethal low levels of oxidative stress leads to rapid activation of the transcription factor nuclear factor-E2-related factor 2 (Nrf2), which upregulates the expression of genes important for detoxification, glutathione synthesis, and defense against ...
Tetsuro Ishii, Eiji Warabi, Giovanni E. Mann   +2 more
doaj   +1 more source

The addition of PD-1/PD-L1 axis blockade to BRAF and MEK inhibition for advanced melanoma patients harboring BRAF mutations: a systematic review and meta-analysis

Brazilian Journal of Oncology, 2022
Objectives: Immune-checkpoint inhibitors (ICI) and targeted-therapies (TT) have become standard options for BRAF-V600 metastatic melanomas (MM). Recently, randomized trials (RCT) addressed the efficacy of combined approaches, with conflicting results. We
Mauricio Fernando Silva Almeida Ribeiro, Camila Bragança Xavier, Allan Andresson Lima Pereira, Mariana Scaranti, Luiza Dib Batista Bugiato Faria, Tatiana Strava Correa, Marina Sahade, David Queiroz Borges Muniz, Olavo Feher, Gustavo dos Santos Fernandes, Artur Katz, Rodrigo Ramella Munhoz   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source