P38 and JNK Mitogen-Activated Protein Kinases Interact With Chikungunya Virus Non-structural Protein-2 and Regulate TNF Induction During Viral Infection in Macrophages [PDF]
Frontiers in Immunology, 2019 Soma Chattopadhyay +2 more
exaly +2 more sources
Biomedicines, 2022 Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) activation occurs in the liver in response to the nutritional and metabolic ...
Robert W. M. Min +4 more
doaj +1 more source
Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway. [PDF]
PLoS ONE, 2016 Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death.
Anna Ju +8 more
doaj +1 more source
The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer
Cells, 2020 The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival ...
Manel B. Hammouda +3 more
doaj +1 more source
Co-regulation of the transcription controlling ATF2 phosphoswitch by JNK and p38
Nature Communications, 2020 The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential ...
Klára Kirsch +13 more
doaj +1 more source
MAPK immunoreactivity in streptozotocin-induced diabetic rat testis [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes.
Yelız Bozdemır Donmez +2 more
doaj +1 more source
DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine. [PDF]
PLoS ONE, 2014 Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a poor prognosis that is characterized by excessive mitogenic pathway activation and marked chemoresistance to a broad spectrum of chemotherapeutic drugs.
Fang Liu +3 more
doaj +1 more source
Time courses of changes in phospho- and total- MAP kinases in the cochlea after intense noise exposure. [PDF]
PLoS ONE, 2013 Mitogen-activated protein kinases (MAP kinases) are intracellular signaling kinases activated by phosphorylation in response to a variety of extracellular stimuli.
Yukihide Maeda +4 more
doaj +1 more source
Effects of MAP4K inhibition on neurite outgrowth
Molecular Brain, 2023 Protein kinases are responsible for protein phosphorylation and are involved in important intracellular signal transduction pathways in various cells, including neurons; however, a considerable number of poorly characterized kinases may be involved in ...
Di Ja Lasham +7 more
doaj +1 more source
Mitogen Activated Protein kinase signal transduction pathways in the prostate
Cell Communication and Signaling, 2004 The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty +3 more
doaj +1 more source