mBio, 2023 Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections.
Jian Feng +7 more
doaj +1 more source
Ultraviolet Light-induced Stimulation of the JNK Mitogen-activated Protein Kinase in the Absence of Src Family Tyrosine Kinase Activation [PDF]
Journal of Biological Chemistry, 2000 In T cells, the JNK mitogen-activated protein kinase is activated by simultaneous stimulation of the T-cell receptor and CD28 or by a number of stress stimuli including ultraviolet light, hydrogen peroxide, and anisomycin. Lck, a Src family kinase, is essential for T-cell receptor-mediated activation of JNK.
K, Amdjadi, B M, Sefton
openaire +2 more sources
Therapeutic Advances in Medical Oncology, 2019 One of the mitogen-activated protein kinases (MAPKs), c-Jun NH2-terminal protein kinase (JNK) plays an important role in regulating cell fate, such as proliferation, differentiation, development, transformation, and apoptosis.
Jae Gwang Park, Nur Aziz, Jae Youl Cho
doaj +1 more source
Biochemistry and Biophysics Reports, 2021 Methylglyoxal (MG) is a metabolite derived from glycolysis whose levels in the blood and tissues of patients with diabetes are higher than those of healthy individuals, suggesting that MG is associated with the development of diabetic complications ...
Su-Ping Ng +5 more
doaj +1 more source
Activation of the Sap-1a Transcription Factor by the c-Jun N-terminal Kinase (JNK) Mitogen-activated Protein Kinase [PDF]
Journal of Biological Chemistry, 1997 Ternary complex factors (TCFs) bind to the serum response element in the c-fos promoter and mediate its activation by many extracellular stimuli. Some of these stimuli activate the ERK subclass of mitogen-activated protein kinases (MAPKs) that target the TCF Sap-1a.
R, Janknecht, T, Hunter
openaire +2 more sources
Oxidative Versus Thrombotic Stimulation of Platelets Differentially activates Signalling Pathways [PDF]
Journal of Cardiovascular and Thoracic Research, 2013 Introduction: Atherosclerosis is one of the inflammatory underlying disease associated by oxidative stress and thrombotic agents. This study aimed to evaluate the potential role of cupper oxidized low-density lipoprotein (OxLDL) and thrombin for inducing
Pouran Karimi, Nadereh Rashtchizadeh
doaj +1 more source
JNK and p38 Mitogen-Activated Protein Kinase Pathways Contribute to Porcine Circovirus Type 2 Infection [PDF]
Journal of Virology, 2009 ABSTRACTInfection with a wide variety of viruses often perturbs host cell signaling pathways including the Jun NH2-terminal kinase/stress-activated kinase (JNK/SAPK) and the p38 mitogen-activated protein kinase (p38/MAPK), which are important components of cellular signal transduction pathways.
Li, Wei +3 more
openaire +2 more sources
Diverse physiological functions for dual-specificity MAP kinase phosphatases [PDF]
, 2006 A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals.
Keyse, Stephen M, Dickinson, Robin J
core +1 more source
Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]
, 2008 We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Vollmar, Angelika M. +2 more
core +1 more source
Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. [PDF]
The Journal of biological chemistry, 1998 Mitogen-activated protein kinase (MAPK) kinases (MKKs) are dual-specificity protein kinases that phosphorylate and activate MAPK. We have isolated a cDNA encoding a novel protein kinase that has significant homology to MKKs. The novel kinase MKK7 has a nucleotide sequence that encodes an open reading frame of 347 amino acids with 11 kinase subdomains ...
Z, Yao +12 more
openaire +2 more sources