Results 41 to 50 of about 177,354 (301)

Brain JNK and metabolic disease [PDF]

Diabetologia, 2020
Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with central insulin and leptin resistance ...
Nogueiras, Rubén, Sabio, Guadalupe
openaire   +2 more sources

The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation [Retraction]

International Journal of COPD, 2023
Chen Z, Zhang Y, Wu J, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:877–885. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Chen Z, Zhang Y, Wu J, Gao X, Huang C, Lin Y, Xu X, Li Y   +7 more
doaj  

JNK isoforms control mammal adult hippocampal neurogenesis

Mexican Journal of Medical Research ICSA, 2020
In mammals, the term “adult hippocampal neurogenesis” defines the process through which, throughout adulthood, new granular neurons are produced by neural stem cells (NSC) in the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus or, by ...
Carme Auladell, Rubén D. Castro-Torres, Oriol Busquets, Miren Ettcheto, Antoni Camins, Ester Verdaguer   +5 more
doaj   +1 more source

OSR1 suppresses acute myeloid leukaemia cell proliferation by inhibiting LGR5-mediated JNK signalling

Autoimmunity, 2021
Odd-skipped related transcription factor 1 (OSR1) is implicated in various pathophysiologic processes, such as embryonic heart and urogenital formation, and functions as a tumour suppressor in diverse tumours.
Lingyan Zong, Yingxin Sun
doaj   +1 more source

JNK Regulation of Oncogenesis

Molecules and Cells, 2006
The literature provides strong precedent for both pro-tumorigenic and tumor suppressor roles for the c-Jun N-terminal kinases (JNKs) in the setting of oncogenesis. Clearly, JNKs are activated by numerous oncogenes and growth factors and the literature documents a role for these MAP kinases in cell proliferation and transformation.
Lynn E, Heasley, Sun-Young, Han
openaire   +2 more sources

Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]

, 2013
Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
Papa, S, Rahemtulla, A, Chaidos, A, Barbarulo, A, Karadimitris, A, Iansante, V, Naresh, K, Haskard, DO, Bubici, C, Franzoso, G   +9 more
core   +1 more source

Graphical illustration of the IRE1-JNK-Beclin 1 signaling pathway involved in SADS-CoV-induced autophagy via PLP2-TM and GRP78 interaction.

, 2023
Graphical illustration of the IRE1-JNK-Beclin 1 signaling pathway involved in SADS-CoV-induced autophagy via PLP2-TM and GRP78 interaction.
Jianfei Chen (3186999), Zhaoyang Jing (9110860), Haojie He (14761730), Hongyan Shi (1988656), Dakai Liu (10474934), Da Shi (1455439), Jingyun Ma (1885213), Tingshuai Feng (14761721), Li Feng (77923), Ling Zhou (51948), Jiyu Zhang (725001), Xin Zhang (35492), Mei Xue (163742), Jianbo Liu (315277), Jialin Zhang (320005), Zhaoyang Ji (14761727), Longjun Guo (315268), Liaoyuan Zhang (12157704), Miaomiao Zeng (14761724), Yang Wu (66682)   +19 more
core   +1 more source

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo

Drug Design, Development and Therapy, 2020
Peng Sun,1,2 Qichang Yang,1 Yanben Wang,2 Jiaxuan Peng,3 Kangxian Zhao,1 Yewei Jia,2 Tan Zhang,2 Xuanyuan Lu,2 Weiqi Han,2 Yu Qian1,2 1The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang ...
Sun P, Yang Q, Wang Y, Peng J, Zhao K, Jia Y, Zhang T, Lu X, Han W, Qian Y   +9 more
doaj  

Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages [PDF]

, 2009
Eicosanoids are a broad family of lipids that play a critical role in host defense against bacterial and fungal infections. The first enzyme in the metabolic pathway for the generation of eicosanoids is group IVA phospholipase A2, also known as cytosolic
Meana González, Clara, Esquinas, Esperanza, Pindado, José, Balsinde Rodríguez, Jesús, Casas Requena, Javier, Valdearcos, Martín, Balboa García, María Ángeles   +6 more
core   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source