Results 51 to 60 of about 164,331 (306)

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease

International Journal of COPD, 2021
Chu-Yun Liu,1 Jian-Hua Wu,1 Zhi-Yuan Chen,1 Yi Zhang,1 Chun-Ling Huang,2 Ai-Mei Lin,1 Xiao-Ting Xu,1 Xiao-Hua Gao1 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China ...
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj  

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

OSR1 suppresses acute myeloid leukaemia cell proliferation by inhibiting LGR5-mediated JNK signalling

Autoimmunity, 2021
Odd-skipped related transcription factor 1 (OSR1) is implicated in various pathophysiologic processes, such as embryonic heart and urogenital formation, and functions as a tumour suppressor in diverse tumours.
Lingyan Zong, Yingxin Sun
doaj   +1 more source

Manipulating JNK Signaling with (−)-Zuonin A [PDF]

ACS Chemical Biology, 2012
Recently, in a virtual screening strategy to identify new compounds targeting the D-recruitment site (DRS) of the c-Jun N-terminal kinases (JNKs), we identified the natural product (-)-zuonin A. Here we report the asymmetric synthesis of (-)-zuonin A and its enantiomer (+)-zuonin A.
Tamer S, Kaoud, Heekwang, Park, Shreya, Mitra, Chunli, Yan, Chun-Chia, Tseng, Yue, Shi, Jiney, Jose, Juliana M, Taliaferro, Kiyoun, Lee, Pengyu, Ren, Jiyong, Hong, Kevin N, Dalby   +11 more
openaire   +2 more sources

The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation [Retraction]

International Journal of COPD, 2023
Chen Z, Zhang Y, Wu J, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:877–885. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Chen Z, Zhang Y, Wu J, Gao X, Huang C, Lin Y, Xu X, Li Y   +7 more
doaj  

JNK isoforms control mammal adult hippocampal neurogenesis

Mexican Journal of Medical Research ICSA, 2020
In mammals, the term “adult hippocampal neurogenesis” defines the process through which, throughout adulthood, new granular neurons are produced by neural stem cells (NSC) in the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus or, by ...
Carme Auladell, Rubén D. Castro-Torres, Oriol Busquets, Miren Ettcheto, Antoni Camins, Ester Verdaguer   +5 more
doaj   +1 more source

Pristimerin Inhibits Osteoclast Differentiation and Bone Resorption in vitro and Prevents Ovariectomy-Induced Bone Loss in vivo

Drug Design, Development and Therapy, 2020
Peng Sun,1,2 Qichang Yang,1 Yanben Wang,2 Jiaxuan Peng,3 Kangxian Zhao,1 Yewei Jia,2 Tan Zhang,2 Xuanyuan Lu,2 Weiqi Han,2 Yu Qian1,2 1The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang ...
Sun P, Yang Q, Wang Y, Peng J, Zhao K, Jia Y, Zhang T, Lu X, Han W, Qian Y   +9 more
doaj  

The IRE1-JNK-Beclin 1 signaling pathway is involved in SADS-CoV-induced autophagy.

, 2023
(A) ST cells that untreated or treated with Control siRNA or siIRE1 for 48 h, are infected with SADS-CoV for 36 h. A western blotling analysis is performed with the indicated antibodies.
Jianfei Chen (3186999), Zhaoyang Jing (9110860), Haojie He (14761730), Hongyan Shi (1988656), Dakai Liu (10474934), Da Shi (1455439), Jingyun Ma (1885213), Tingshuai Feng (14761721), Li Feng (77923), Ling Zhou (51948), Jiyu Zhang (725001), Xin Zhang (35492), Mei Xue (163742), Jianbo Liu (315277), Jialin Zhang (320005), Zhaoyang Ji (14761727), Longjun Guo (315268), Liaoyuan Zhang (12157704), Miaomiao Zeng (14761724), Yang Wu (66682)   +19 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease [Retraction]

International Journal of COPD, 2023
Liu CY, Wu JH, Chen ZY, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:2375–2383. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj