Results 51 to 60 of about 167,128 (299)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Cells, 2019 Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast cancer. These functions are partly mediated through Smads, intracellular transcriptional effectors of TGFβ.
Anders Sundqvist +10 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz +9 more
wiley +1 more source
Applied Sciences, 2022 In this study, the CO2 sorption mechanisms and regeneration properties of alumina-based sorbent using K2CO3 loading under high-pressure and moderate temperature conditions were examined.
Do-Yeong Ryu +10 more
doaj +1 more source
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site [PDF]
Proceedings of the National Academy of Sciences, 2008 JNK is a stress-activated protein kinase that modulates pathways implicated in a variety of disease states. JNK-interacting protein-1 (JIP1) is a scaffolding protein that enhances JNK signaling by creating a proximity effect between JNK and upstream kinases. A minimal peptide region derived from JIP1 is able to inhibit JNK activity
John L, Stebbins +12 more
openaire +2 more sources
The IRE1-JNK-Beclin 1 signaling pathway is involved in SADS-CoV-induced autophagy.
, 2023 (A) ST cells that untreated or treated with Control siRNA or siIRE1 for 48 h, are infected with SADS-CoV for 36 h. A western blotling analysis is performed with the indicated antibodies.
Jianfei Chen (3186999) +19 more
core +1 more source
Advanced Materials for Biologics Delivery to Brain Tumors
Advanced Materials, EarlyView.Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng +4 more
wiley +1 more source
International Journal of COPD, 2021 Zhi-yuan Chen,1 Yi Zhang,1 Jian-hua Wu,1 Xiao-hua Gao,1 Chun-ling Huang,2 Yu-mei Lin,1 Xiao-ting Xu,1 Yan Li1 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China ...
Chen Z +7 more
doaj
Rosuvastatin Attenuates CD40L-Induced Downregulation of Extracellular Matrix Production in Human Aortic Smooth Muscle Cells via TRAF6-JNK-NF-κB Pathway. [PDF]
, 2016 CD40L and statins exhibit pro-inflammatory and anti-inflammatory effects, respectively. They are both pleiotropic and can regulate extracellular matrix (ECM) degeneration in an atherosclerotic plaque. Statins can decrease both the CD40 expression and the
Wang Xiao-Lin +10 more
core +1 more source