Results 1 to 10 of about 243,463 (204)
p38 MAPK inhibition: A promising therapeutic approach for COVID-19
Journal of Molecular and Cellular Cardiology, 2020 COVID-19, caused by the SARS-CoV-2 virus, is a major source of morbidity and mortality due to its inflammatory effects in the lungs and heart. The p38 MAPK pathway plays a crucial role in the release of pro-inflammatory cytokines such as IL-6 and has ...
Joseph M. Grimes, Kevin Grimes
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p38 MAPK signalling in osteoblast differentiation
Frontiers in Cell and Developmental Biology, 2016 The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post ...
Edgardo eRodríguez-Carballo +2 more
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Activation and signaling of the p38 MAP kinase pathway
Cell Research, 2005 The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction ...
Jiahuai Han, Han Jiahuai
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Aging, 2015 Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Gañán-Gómez, I. (Irene) +2 more
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International Journal of Molecular Sciences, 2021 p38 Mitogen activated protein kinases (p38MAPK) are a highly evolutionary conserved group of protein kinases, which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration, and tumour formation [...]
Juan José Sanz-Ezquerro, Ana Cuenda
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Folia Histochemica et Cytobiologica, 2022 INTRODUCTION: Suppressing the phenotype of cancer stem cells (CSCs) is a promising treatment strategy for cancer. P38 mitogen-activated protein kinases (MAPK, p38) play an important role in the occurrence, development, and stemness maintenance of tumors.
Jin Zhao +5 more
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Diversity and versatility of p38 kinase signalling in health and disease
Nature reviews. Molecular cell biology, 2021 The ability of cells to deal with different types of stressful situations in a precise and coordinated manner is key for survival and involves various signalling networks.
Begoña Cánovas, A. Nebreda
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Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa
Di-san junyi daxue xuebao, 2022 Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H.
YAN Zongbao +4 more
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Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
International Journal of Molecular Sciences, 2022 c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way.
Lesley Jia Wei Pua +6 more
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The Effect of Doxycycline on PMA-Induced MUC5B Expression via MMP-9 and p38 in NCI-H292 Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2011 ObjectivesDoxycycline is commonly used in medicine for its bacteriostatic antimicrobial properties. Recent studies have reported that doxycycline also has anti-inflammatory effects.
Chang Hoon Bae +4 more
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