New inhibitors of p38 mitogen-activated protein kinase: Repurposing of existing drugs with deep learning [PDF]
, 2021 P38-alpha (MAPK14) is a protein kinase that is implicated in the pathological mechanisms of BAG3 P209L myofibrillar myopathy, cancers, Alzheimer’s disease and other diseases like rheumatoid arthritis.
Valentina, Kouznetsova +2 more
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The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Eales, Katherine L. +1 more
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Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate [PDF]
, 2011 p38 mitogen-activated protein kinase plays a pivotal role in skin inflammation. The purpose of this study was to investigate the role of the various p38 isoforms. p38 beta/delta-knockout-C57BL/6 mice were generated, studied in a 12-O-tetradecanoylphorbol
Iversen, Lars +13 more
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The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]
, 2010 Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo +33 more
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p38 MAPK signalling in osteoblast differentiation
Frontiers in Cell and Developmental Biology, 2016 The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post ...
Edgardo eRodríguez-Carballo +2 more
doaj +1 more source
Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]
, 2012 Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A. +7 more
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Effect of Epigallocatechin-3-Gallate on PMA-Induced MUC5B Expression in Human Airway Epithelial Cells [PDF]
Clinical and Experimental Otorhinolaryngology, 2013 ObjectivesAmong the inflammatory mediators, phorbol 12-myristate 13-acetate (PMA) is associated with the regulation of MUC5B expression in the airway epithelial cells. Epigallocatechin-3-gallate (EGCG) is the major component of green tea extract.
Eun Jung Song +6 more
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C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]
, 2003 Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B. +4 more
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Frontiers in Pharmacology, 2020 Intracerebral hemorrhage (ICH) is a disease with a significantly high rate of morbidity, mortality and disability. Inhibition of inflammation is considered a potential strategy for improving the clinical symptoms induced by ICH.
Lu Zhou +7 more
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Cells, 2023 We have recently reported that in G2-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G2-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle through ...
Daxian Luo +4 more
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