Results 31 to 40 of about 281,509 (352)
Functions of p38 MAP Kinases in the Central Nervous System
Frontiers in Molecular Neuroscience, 2020 Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a multitude of mammalian cell types. This review covers recent advances on specific functions of p38 MAP kinases in cells of the central nervous system.
Prita R. Asih +5 more
semanticscholar +1 more source
Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
Nature Immunology, 2020 Increasing age alters innate immune–mediated responses; however, the mechanisms underpinning these changes in humans are not fully understood. Using a human dermal model of acute inflammation, we found that, although inflammatory onset is similar between
Roel P. H. De Maeyer +8 more
semanticscholar +1 more source
Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Karslı, Gizem +23 more
core +2 more sources
Molecular mechanism of inhibition of 8-gingerol on proliferation of breast cancer cells
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of cell cycle on breast cancer cells by 8-gingerol. Methods The cell viability of breast cancer cells MDA-MB-231 and MCF-7 after treated by 8-gingerol at the doses of 0, 10, 20, 30 or 40 μmol/L for 24, 48 or 72 h was ...
YANG Chong, FU Ruoqiu, GAO Ning
doaj +1 more source
European Journal of Cancer Supplements, 2015 The efficiency of endocrine therapy for tumors is limited by the development of hormone resistance and progression of tumor cells to hormone-independent phenotype. Among these tumors – breast cancers, for which hormone therapy is one of the most common and effective methods of treatment, but only in cases, when the tumors retain their hormonal ...
S. Semina, M. Krasil’nikov
openaire +2 more sources
p38 MAPK Pathway in the Heart: New Insights in Health and Disease
International Journal of Molecular Sciences, 2020 The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli. p38 function has been studied in depth in relation to cardiac development and function.
Rafael Romero-Becerra +3 more
semanticscholar +1 more source
A role for p38 MAPK in the regulation of ciliary motion in a eukaryote [PDF]
, 2011 BACKGROUND: Motile cilia are essential to the survival and reproduction of many eukaryotes; they are responsible for powering swimming of protists and small multicellular organisms and drive fluids across respiratory and reproductive surfaces in mammals.
Walker, Anthony J. +11 more
core +1 more source
LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling
Journal of Experimental & Clinical Cancer Research, 2019 Background The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is reported to be associated with multiple malignancies, but its role in the progression of pancreatic ductal adenocarcinoma (PDAC) remains to be determined.
Zhi-Bo Xie +4 more
doaj +1 more source
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
Journal of Neuroinflammation, 2011 Background Neuropeptide Y (NPY) is emerging as a modulator of communication between the brain and the immune system. However, in spite of increasing evidence that supports a role for NPY in the modulation of microglial cell responses to inflammatory ...
Ferreira Raquel +6 more
doaj +1 more source
Peroxiredoxin 3 Inhibits Cardiac Fibrosis in Mice via NOX4-P38 Signalling [PDF]
Cell Journal, 2023 Objective: Peroxiredoxin-3 (Prx-3) is widely acknowledged as an antioxidant that protects against mitochondrialreactive oxygen species. Nonetheless, its role in cardiac fibrosis has not been elucidated. We aim to explore the roleand mechanism of Prx-3 in
Xiaoqi Xiong +9 more
doaj +1 more source