Results 31 to 40 of about 218,916 (306)

A role for p38 MAPK in the regulation of ciliary motion in a eukaryote [PDF]

, 2011
BACKGROUND: Motile cilia are essential to the survival and reproduction of many eukaryotes; they are responsible for powering swimming of protists and small multicellular organisms and drive fluids across respiratory and reproductive surfaces in mammals.
Walker, Anthony J., Ressurreicao, Margarida, Margarida Ressurreição, Ressurreição Margarida, Aidan M Emery, David Rollinson, Rollinson, David, Emery Aidan M, Walker Anthony J, Anthony J Walker, Emery, Aidan M., Rollinson David   +11 more
core   +1 more source

Mongolian medicine theory-based multidimensional evaluation of toxicity mitigation in Hezi-processed Caowu jointly mediated by powder dosage form and small dose

Frontiers in Pharmacology
BackgroudCaowu (CW, Aconitum kusnezoffii Reichb.) is a well-known Mongolian medicine with the effects of dispelling cold and relieving pain. In China, it is widely used in the prevention and treatment of rheumatoid arthritis (RA).
Jing Wang, Liyuan Bao, Ying Zhao, Liangliang Song, Wenting Zu, Jiasheng Wang, Hongshuang Chi, Yichen Li, Hong Du   +8 more
doaj   +1 more source

SUMOs Mediate the Nuclear Transfer of p38 and p-p38 during Infection [PDF]

, 2018
The p38 mitogen activated protein kinase (MAPK) signaling pathway has been suggested to play a significant role in the gastric mucosal inflammatory response to chronic Helicobacter pylori (H. pylori) infection.
Ping Hsu, Lynn Marie Powell, Pin Wang, Lynn Powell, Andrew Paul Jarman, Powell, Lynn Marie, Angela Chen, Hsu, Ping I, Jarman, Andrew Paul, Deng Chyang Wu, Wu, Deng Chyang, Wang, Pin Yao, Chen, Angela, Pin Yao Wang, Ping I. Hsu, Te Chung Chen, Deng Wu, Te Chen, Andrew Jarman, Chen, Te Chung   +19 more
core   +1 more source

WMJ-S-001, a Novel Aliphatic Hydroxamate-Based Compound, Suppresses Lymphangiogenesis Through p38mapk-p53-survivin Signaling Cascade

Frontiers in Oncology, 2019
Background and purpose: Angiogenesis and lymphangiogenesis are major routes for metastatic spread of tumor cells. It thus represent the rational targets for therapeutic intervention of cancer.
Shiu-Wen Huang, Shiu-Wen Huang, Hung-Yu Yang, Hung-Yu Yang, Wei-Jan Huang, Wei-Chuan Chen, Meng-Chieh Yu, Shih-Wei Wang, Shih-Wei Wang, Ya-Fen Hsu, Ming-Jen Hsu, Ming-Jen Hsu   +11 more
doaj   +1 more source

Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis

Frontiers in Immunology, 2019
Mannan-binding lectin (MBL) is a vital element in the host innate immune system, which is primarily produced by the liver and secreted into the circulation. Low serum level of MBL is reported to be associated with an increased risk of arthritis. However,
Lijun Dong, Jun Wu, Kai Chen, Jingwen Xie, Youyi Wang, Youyi Wang, Dantong Li, Yunzhi Liu, Aiping Yin, Yue Zhao, Yunpeng Han, Jia Zhou, Liyun Zhang, Zhengliang Chen, Zhengliang Chen, Daming Zuo, Daming Zuo, Daming Zuo, Daming Zuo   +18 more
doaj   +1 more source

p38 MAPK in MDS

Aging, 2015
Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Gañán-Gómez, I. (Irene), Bohannan, Z.S. (Zachary S.), Garcia-Manero, G. (Guillermo)   +2 more
openaire   +3 more sources

p8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth

Molecular Cancer, 2003
Background p8 is a stress-induced protein with multiple functions and biochemically related to the architectural factor HMG-I/Y. We analyzed the expression and function of p8 in pancreatic cancer-derived cells.
Vasseur Sophie, Lesavre Nathalie, Malicet Cédric, Iovanna Juan L   +3 more
doaj   +1 more source

7-Hydroxyflavone Alleviates Myocardial Ischemia/Reperfusion Injury in Rats by Regulating Inflammation

Molecules, 2022
Inflammation is the primary pathological process of myocardial ischemia/reperfusion injury (MI/RI). 7-Hydroxyflavone (HF), a natural flavonoid with a variety of bioactivities, plays a crucial role in various biological processes.
Qunhui Zhang, Yanfeng Peng, Jiangyu Liu, Yongjing Yang, Zhangjie Hu, Yi Zhou, Jing Ma, Dejun Zhang   +7 more
doaj   +1 more source

Knockdown of chemerin decreased proteins associated with p-p38-MAPK.

, 2016
Protein levels of NF-κBp65 (A), PCNA (B), p-ERK 1/2 (C), and p-p38-MAPK (D) in VSMCs and carotid tissues were up-regulated by PDGF-BB (20ng/mL) or carotid angioplasty. Up-regulation of these factors was significantly inhibited by knockdown of chemerin in
Wei Xiong (58411), Bihong Liao (3280836), Lin Wu (153444), Yu Luo (277978), Jianghua Li (390525), Huadong Liu (84382), Shaohong Dong (3280839), Feng Liu (72874)   +7 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source