Results 41 to 50 of about 281,509 (352)
CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway
Journal of Experimental & Clinical Cancer Research, 2019 Background Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria.
Mansi Babbar +3 more
doaj +1 more source
Journal of Biological Chemistry, 1995 Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in response to growth factors via a Ras-dependent mechanism.
J. Raingeaud +6 more
semanticscholar +1 more source
Virus-induced p38 MAPK activation facilitates viral infection
Theranostics, 2020 Rationale: Many viral infections are known to activate the p38 mitogen-activated protein kinase (MAPK) signaling pathway. However, the role of p38 activation in viral infection and the underlying mechanism remain unclear.
Yuting Cheng +13 more
semanticscholar +1 more source
Cancer Letters, 2019 Metastasis is the leading cause of breast cancer-related deaths. Cancer-associated fibroblasts (CAFs), the predominant stromal cell type in the breast tumour microenvironment, may contribute to cancer progression through interaction with tumour cells ...
S. Wen +9 more
semanticscholar +1 more source
Akt2, a Novel Functional Link between p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Myogenesis [PDF]
, 2004 Activation of either the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt or the p38 mitogen-activated protein kinase (MAPK) signaling pathways accelerates myogenesis but only when the reciprocal pathway is functional. We therefore examined the hypothesis
Holding, C. +15 more
core +1 more source
Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation [PDF]
, 2006 Cell-cell contact is essential for appropriate co-ordination of development and it initiates significant signalling events. During myogenesis, committed myoblasts migrate to sites of muscle formation, align and form adhesive contacts that instigate cell ...
Cobb, L.J. +8 more
core +1 more source
Frontiers in PharmacologyBackgroudCaowu (CW, Aconitum kusnezoffii Reichb.) is a well-known Mongolian medicine with the effects of dispelling cold and relieving pain. In China, it is widely used in the prevention and treatment of rheumatoid arthritis (RA).
Jing Wang +8 more
doaj +1 more source
Shape-Induced Terminal Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation [PDF]
, 2011 PMCID: PMC3206954This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Connelly, JT +18 more
core +2 more sources
On the role of ras and BRF1 in the regulation of ARE-dependent mRNA-turnover [PDF]
, 2004 Stability of the mRNAs of cytokines, chemokines, growth-factors, protooncogenes and others are regulated via an AU-rich element (ARE) in their 3’ untranslated region (UTR).
Leuenberger, Sabrina Angélique
core +1 more source
Frontiers in Oncology, 2019 Background and purpose: Angiogenesis and lymphangiogenesis are major routes for metastatic spread of tumor cells. It thus represent the rational targets for therapeutic intervention of cancer.
Shiu-Wen Huang +11 more
doaj +1 more source