Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]
, 2004 The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J. +9 more
core +1 more source
Molecular mechanism of inhibition of 8-gingerol on proliferation of breast cancer cells
Di-san junyi daxue xuebao, 2019 Objective To investigate the effect of cell cycle on breast cancer cells by 8-gingerol. Methods The cell viability of breast cancer cells MDA-MB-231 and MCF-7 after treated by 8-gingerol at the doses of 0, 10, 20, 30 or 40 μmol/L for 24, 48 or 72 h was ...
YANG Chong, FU Ruoqiu, GAO Ning
doaj +1 more source
European Journal of Cancer Supplements, 2015 The efficiency of endocrine therapy for tumors is limited by the development of hormone resistance and progression of tumor cells to hormone-independent phenotype. Among these tumors – breast cancers, for which hormone therapy is one of the most common and effective methods of treatment, but only in cases, when the tumors retain their hormonal ...
S. Semina, M. Krasil’nikov
openaire +2 more sources
Akt2, a Novel Functional Link between p38 Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways in Myogenesis [PDF]
, 2004 Activation of either the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt or the p38 mitogen-activated protein kinase (MAPK) signaling pathways accelerates myogenesis but only when the reciprocal pathway is functional. We therefore examined the hypothesis
Holding, C. +15 more
core +1 more source
Increased activation of p38 MAPK in COPD. [PDF]
, 2008 Inflammation, oxidative stress and apoptosis, which are involved in chronic obstructive pulmonary disease (COPD) pathogenesis, may activate the p38 subgroup of mitogen-activated protein kinases (MAPKs).
A. Vatrella +25 more
core +2 more sources
LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling
Journal of Experimental & Clinical Cancer Research, 2019 Background The abnormal expression of leucine-rich-alpha-2-glycoprotein 1 (LRG-1) is reported to be associated with multiple malignancies, but its role in the progression of pancreatic ductal adenocarcinoma (PDAC) remains to be determined.
Zhi-Bo Xie +4 more
doaj +1 more source
Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β
, 2023 The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various cellular responses to stress conditions, inflammatory signals, and differentiation factors.
Jonah Beenstock +3 more
core +1 more source
Neuropeptide Y inhibits interleukin-1β-induced phagocytosis by microglial cells
Journal of Neuroinflammation, 2011 Background Neuropeptide Y (NPY) is emerging as a modulator of communication between the brain and the immune system. However, in spite of increasing evidence that supports a role for NPY in the modulation of microglial cell responses to inflammatory ...
Ferreira Raquel +6 more
doaj +1 more source
Peroxiredoxin 3 Inhibits Cardiac Fibrosis in Mice via NOX4-P38 Signalling [PDF]
Cell Journal, 2023 Objective: Peroxiredoxin-3 (Prx-3) is widely acknowledged as an antioxidant that protects against mitochondrialreactive oxygen species. Nonetheless, its role in cardiac fibrosis has not been elucidated. We aim to explore the roleand mechanism of Prx-3 in
Xiaoqi Xiong +9 more
doaj +1 more source
CHTM1 regulates cancer cell sensitivity to metabolic stress via p38-AIF1 pathway
Journal of Experimental & Clinical Cancer Research, 2019 Background Recently, we have reported the characterization of a novel protein named Coiled-coil Helix Tumor and Metabolism 1 (CHTM1). CHTM1 localizes to both cytosol and mitochondria.
Mansi Babbar +3 more
doaj +1 more source