Results 21 to 30 of about 281,509 (352)

Effect of miR-21 on apoptosis in hepatoblastoma cell through activating ASPP2/p38 signaling pathway in vitro and in vivo

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The objective of this study was to investigate the mechanism underlying miR-21-associated apoptosis in HB. In this study, HB and adjacent tissues were collected from patients with HB.
Lili Liu, Likun Wang, Xidong Li, Ping Tian, Hao Xu, Zenglian Li, Enqin Liu   +6 more
doaj   +1 more source

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice [PDF]

, 2010
Nearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to osteoblast biology in vivo. Here we
Zhai, Bo, Weiguo Zou, Shim, Jae-Hyuck, Hu, Dorothy, Lotinun, Sutada, Glimcher, Laurie H., Arthur, Simon; id_orcid, Michael D. Schneider, Yasuyo Sano, Min Xie, Matthew B. Greenblatt, Laurie H. Glimcher, Jae-Hyuck Shim, Roger Davis, Xie, Min, Sano, Yasuyo, Despina Sitara, Schweitzer, Michelle, Park, Jin Mo, Schneider, Michael D., Gygi, Steven, Greenblatt, Matthew B., Baron, Roland, Simon Arthur, Zou, Weiguo, Jin Mo Park, Michelle Schweitzer, Davis, Roger, Roland Baron, Sitara, Despina, Sutada Lotinun, Dorothy Hu, Bo Zhai, Steven Gygi   +33 more
core   +1 more source

Involvement of p38 MAPK in Synaptic Function and Dysfunction

International Journal of Molecular Sciences, 2020
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD).
Chiara Falcicchia, Francesca Tozzi, O. Arancio, D. Watterson, N. Origlia   +4 more
semanticscholar   +1 more source

C-Jun N-terminal kinases/c-Jun and p38 pathways cooperate in ceramide-induced neuronal apoptosis [PDF]

, 2003
Understanding the regulation of the apoptotic program in neurons by intracellular pathways is currently a subject of great interest. Recent results suggest that c-Jun N-terminal kinases (JNK), mitogen-activated protein kinases and the transcription ...
Brugg, B., Caboche, J., Willaime-Morawek, S., Brami-Cherrier, K., Mariani, J.   +4 more
core   +1 more source

Effect of Epigallocatechin-3-Gallate on PMA-Induced MUC5B Expression in Human Airway Epithelial Cells [PDF]

Clinical and Experimental Otorhinolaryngology, 2013
ObjectivesAmong the inflammatory mediators, phorbol 12-myristate 13-acetate (PMA) is associated with the regulation of MUC5B expression in the airway epithelial cells. Epigallocatechin-3-gallate (EGCG) is the major component of green tea extract.
Eun Jung Song, Chang Hoon Bae, Jong-Yeon Kim, Yong-Woon Kim, So-Young Park, Si-Youn Song, Yong-Dae Kim   +6 more
doaj   +1 more source

Bridelia ferruginea Produces Anti-neuroinflammatory Activity through Inhibition of Nuclear Factor-kappa B and p38 MAPK Signalling [PDF]

, 2012
Bridelia ferruginea is commonly used in traditional African medicine (TAM) for treating various inflammatory conditions. Extracts from the plant have been shown to exhibit anti-inflammatory property in a number of in vivo models.
Aderogba, Mutallib A., Fiebich, Bernd L., Aderogba, Mutalib A., Okorji, Uchechukwu P., Okorji, U. P., Fiebich, B.L., Olajide, Olumayokun A.   +6 more
core   +1 more source

DHZCP Modulates Microglial M1/M2 Polarization via the p38 and TLR4/NF-κB Signaling Pathways in LPS-Stimulated Microglial Cells

Frontiers in Pharmacology, 2020
Intracerebral hemorrhage (ICH) is a disease with a significantly high rate of morbidity, mortality and disability. Inhibition of inflammation is considered a potential strategy for improving the clinical symptoms induced by ICH.
Lu Zhou, Dongsheng Wang, Xinjian Qiu, Weiru Zhang, Zhicheng Gong, Yang Wang, Xia Xu, Xia Xu   +7 more
doaj   +1 more source

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G₂-Checkpoint Activation in Cells Exposed to Ionizing Radiation

Cells, 2023
We have recently reported that in G2-phase cells (but not S-phase cells) sustaining low loads of DNA double-strand break (DSBs), ATM and ATR regulate the G2-checkpoint epistatically, with ATR at the output-node, interfacing with the cell cycle through ...
Daxian Luo, Emil Mladenov, Aashish Soni, Martin Stuschke, George Iliakis   +4 more
doaj   +1 more source

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

F1000Research, 2020
The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli.
Jiahuai Han, Jian-feng Wu, J. Silke
semanticscholar   +1 more source

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J., Jaeger, S., Tempst, P., Puigserver, P., Fan, M., Handschin, C., St-Pierre, J., Spiegelman, B. M., Rhee, J., Erdjument-Bromage, H.   +9 more
core   +1 more source