Results 61 to 70 of about 166,874 (259)

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Marine sponge‐derived smenospongine preferentially eliminates breast cancer stem‐like cells via p38/AMPKα pathways

Cancer Medicine, 2018
Breast cancer stem cells (CSCs) have been postulated as responsible for therapeutic failure of breast cancer. Novel agents effectively targeting breast CSCs are urging to be discovered to overcome cancer relapse and metastasis.
Jie Tang, Wei Wu, Fan Yang, Liyun Liu, Zhen Yang, Li Liu, Weizhuo Tang, Fan Sun, Houwen Lin   +8 more
doaj   +1 more source

Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling

Frontiers in Pharmacology, 2010
Danshen has been used in traditional Chinese medicine (TCM) for hundreds of years to treat cardiovascular diseases. However, its precise cardioprotective components and the underlying mechanism are still unclear.
Chang-Sheng Du, Rui-Fang Yang, Shu-Wei Song, Yi-Ping Wang, Jiu-Hong Kang, Ru Zhang, Ding-Feng Su, Xin Xie, Xin Xie   +8 more
doaj   +1 more source

Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway

Frontiers in Pharmacology, 2020
Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer’s disease (AD) pathogenesis. Thus, inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The
Nana Chen, Nana Chen, Jiao Wang, Yuqi He, Yuqi He, Yuqi He, Yingshu Xu, Yuchuan Zhang, Qihai Gong, Qihai Gong, Qihai Gong, Changyin Yu, Jianmei Gao, Jianmei Gao, Jianmei Gao   +14 more
doaj   +1 more source

p38 MAP Kinase inhibitor

Japanese Journal of Clinical Immunology, 2007
FR167653 is a potent inhibitor of p38 MAP Kinase and inhibits TNF-alpha and IL-1beta production in inflammatory cells. In this study we investigated the effect of FR167653 on CIA. CIA rats were subcutaneously injected with FR167653 (32 mg/kg/day) starting on the day of the booster injection and after the onset of arthritis in the prophylactic and ...
NISHIKAWA, Masataka, MYOUI, Akira, TOMITA, Tetsuya, TAKAHI, Koichiro, NAMPEI, Akihide, YOSHIKAWA, Hideki   +5 more
openaire   +3 more sources

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

The Effect of Eight Weeks of Intermittent Rehabilitation Training with Quercetin ‎Nanoliposome on the Apoptotic Indices of P38 and MK2 in Male Rats with Isoproterenol ‎Induced Myocardial Infarction Model [PDF]

Journal of Paramedical Science and Rehabilitation
Purpose:Quercetin is effective in the rehabilitation and treatment of apoptosis caused by cardiac ischemia, however, due to its low solubility in water, it is not suitable for clinical application, which can be improved by turning it into nanoparticles ...
S Ahmadi, F Taghian, Kh Jalali Dehkordi, M Kargar Fard   +3 more
doaj   +1 more source

SnapShot: p38 MAPK Signaling

Cell, 2013
Mitogen-activated protein kinase (MAPK) pathways are important regulators of cellular responses to many extracellular stimuli. Typically, eukaryotic cells have several parallel MAPK pathways, which allow the integration of signals from different stimuli.
Natalia Trempolec, Natalia Dave-Coll, Angel R. Nebreda   +2 more
openaire   +2 more sources