Results 71 to 80 of about 281,509 (352)

Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38

Scientific Reports, 2017
The aim of the present study was to examine the antioxidative activity of (+)-lariciresinol (LRSL), an optically active lignan isolated from Rubia philippinensis in several in vitro assays.
V. Bajpai, M. Alam, Khong Trong Quan, Kyoo-Ri Kwon, Mi-Kyoung Ju, Hee-Jeong Choi, Jong Sung Lee, J. Yoon, R. Majumder, I. Rather, Kangmin Kim, Sang-Han Lee, M. Na   +12 more
semanticscholar   +1 more source

Blocking p38 Signaling Reduces the Activation of Pro-inflammatory Cytokines and the Phosphorylation of p38 in the Habenula and Reverses Depressive-Like Behaviors Induced by Neuroinflammation

, 2018
Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive.
Zhao, Ya-wei, Pan, Yu-qin, Ming-ming Tang, Tang, Ming-ming, Lin, Wen-juan, Yu-qin Pan, Ya-wei Zhao, Wen-juan Lin   +7 more
core   +1 more source

Inhibition of p38 pathway leads to OA-like changes in a rat animal model [PDF]

, 2012
Objectives\ud \ud The p38 mitogen-activated protein kinase (MAPK) signal transduction pathway is involved in a variety of inflammatory responses, including cytokine generation, cell differentiation proliferation and apoptosis.
Shi, Wei, Wang, Yanping, Prasadam, Indira, Mao, Xinzhan, Crawford, Ross, Xiao, Yin   +5 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Long-term aerobic exercise training-induced anti-inflammatory response and mechanisms: Focusing on the toll-like receptor 4 signaling pathway

Chinese Journal of Physiology, 2020
Toll-like receptor 4 (TLR-4), which regulate inflammatory reactions, has become a popular research topic in recent years. This article reviews the latest scientific evidence on the regulation of TLR-4 by regular aerobic exercise training.
Chien-Wei Chen, Yu-Chi Kuo, Chorng-Kuang How, Chi-Chang Juan   +3 more
doaj   +1 more source

MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]

, 2007
Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder, Stefan Zahler, Eilken, H.M., Bubik, M.F., Vollmar, Angelika M., Alexandra K. Kiemer, Kiemer, Alexandra K., Zahler, S., Fürst, Robert, Robert Fürst, Schroeder, Timm, Martin F. Bubik, Angelika M. Vollmar, Hanna M. Eilken, Vollmar, A.M., Eilken, Hanna M., Fürst, R., Bubik, Martin F., Zahler, Stefan, Schroeder, T., Kiemer, A.K.   +20 more
core   +1 more source

Data_Sheet_2_Estrogen Suppresses Cytokines Release in cc4821 Neisseria meningitidis Infection via TLR4 and ERβ-p38-MAPK Pathway.PDF

, 2022
Estrogen has long been known to possess immune-modulatory effects in diseases, and multiple pathological conditions show great sex disparities. However, the impact of estrogen in Neisseria meningitidis infection has not been determined. The present study
Juan Xu (225010), Hao Liang (188241), Wanying Gao (12314723), Yuan Gao (159945), Maojun Zhang (236553), Guangfu Yu (12314726), Zhujun Shao (283367), Pengbo Guo (6059666), Ziman Chen (11951665), Li Xu (108702)   +9 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Fibroblast-specific genetic manipulation of p38 MAPK in vivo reveals its central regulatory role in fibrosis

Circulation, 2017
Background: In the heart, acute injury induces a fibrotic healing response that generates collagen-rich scarring that is at first protective but if inappropriately sustained can worsen heart disease.
J. Molkentin, Darrian Bugg, Natasha Ghearing, L. Dorn, P. Kim, Michelle A Sargent, J. Gunaje, K. Otsu, Jennifer M Davis   +8 more
semanticscholar   +1 more source

Data_Sheet_1_Estrogen Suppresses Cytokines Release in cc4821 Neisseria meningitidis Infection via TLR4 and ERβ-p38-MAPK Pathway.PDF

, 2022
Estrogen has long been known to possess immune-modulatory effects in diseases, and multiple pathological conditions show great sex disparities. However, the impact of estrogen in Neisseria meningitidis infection has not been determined. The present study
Juan Xu (225010), Hao Liang (188241), Wanying Gao (12314723), Yuan Gao (159945), Maojun Zhang (236553), Guangfu Yu (12314726), Zhujun Shao (283367), Pengbo Guo (6059666), Ziman Chen (11951665), Li Xu (108702)   +9 more
core   +1 more source