Results 71 to 80 of about 218,916 (306)
Alignment of the barnacle p38 MAPK sequence with that of other species.
, 2012 Balanus amphitrite p38 (Ba-p38, JQ277477) was aligned with human p38α (Hs-p38, Q16539.3), Drosophila melanogaster p38α (Dm-p38, NP_477163.1), Suberites domuncula p38 (Sd-p38, CAC80141.1), Caenorhabditis elegans p38 (Ce-p38, AAB00664.1), Hydroides elegans
Shu-Hua Qi (124759) +6 more
core +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Cells, 2020 : Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj +1 more source
, 2013 Astrocytes were transfected with SHP2WT, SHP2CS, p38 or p38agf plasmids and stimulated with or without IL-1β for 5, 15 and 25 min. Whole cell protein lysates were collected and equivalent amounts were resolved by SDS-PAGE, transferred and immunoblotted ...
Manmeet K. Mamik (306235) +1 more
core +1 more source
ORFV113 induces p38 phosphorylation and IL-8 transcription.
, 2021 (A) Expression of ORFV113 induces p38 phosphorylation. HFF1 cells untreated, UV treated or transfected with pCMV-HA (Empty HA plasmid) or pCMV-ORFV113HA (ORFV113HA plasmid) were harvested at respective time points.
Gustavo Delhon (4336627) +3 more
core +1 more source
Advanced Science, EarlyView.Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Chaeyeon Park +13 more
wiley +1 more source
Cancer Medicine, 2018 Breast cancer stem cells (CSCs) have been postulated as responsible for therapeutic failure of breast cancer. Novel agents effectively targeting breast CSCs are urging to be discovered to overcome cancer relapse and metastasis.
Jie Tang +8 more
doaj +1 more source
Frontiers in Pharmacology, 2010 Danshen has been used in traditional Chinese medicine (TCM) for hundreds of years to treat cardiovascular diseases. However, its precise cardioprotective components and the underlying mechanism are still unclear.
Chang-Sheng Du +8 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer’s disease (AD) pathogenesis. Thus, inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The
Nana Chen +14 more
doaj +1 more source
EV71 infection triggers p38 MAPK phosphorylation downstream of MINK.
, 2015 Western blot analysis was performed to assess the levels of phosphorylated p38 MAPK (phospho-p38) at 0, 2, 4, 6, 8, 10 and 12hpi. Total p38 (t-p38) was probed as an internal control for p38 MAPK protein expression and β-actin was used as a loading ...
Bryan Kit Teck Ong (699835) +2 more
core +1 more source