Results 91 to 100 of about 218,916 (306)

Synthesis, characterization and pharmacological evaluation of pyrazolyl urea derivatives as potential anti-inflammatory agents

Acta Pharmaceutica Sinica B, 2017
p38α mitogen activated protein kinase (MAPK) inhibitors provide a novel approach for the treatment of inflammatory disorders. A series of fifteen pyrazolyl urea derivatives (3ao) were synthesized and evaluated for their p38α MAPK inhibition and ...
Kanagasabai Somakala, Mohammad Amir
doaj   +1 more source

BCAR1, phospho-BCAR1, p38 and phospho-p38 expression in NSCLC tissues and cells.

, 2013
A: Immunoblotting indicated either BCAR1 or phospho-p38(Thr180/Tyr182) levels in three NSCLC tissues (C) were significantly higher than in the adjacent normal tissues (N). But phospho-BCAR1 (Tyr410) and p38 levels in NSCLC and the adjacent normal tissues
Wei Huang (36889), Yao-Guang Jiang (324770), Bo Deng (324764), Jing-Hai Zhou (324772), Yong He (115255), Qun-You Tan (324767), Ru-Wen Wang (324765)   +6 more
core   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

MiR-497-5p regulates ox-LDL-induced dysfunction in vascular endothelial cells by targeting VEGFA/p38/MAPK pathway in atherosclerosis

Heliyon
Background: The impairment of endothelial cells triggered by oxidized low-density lipoprotein (ox-LDL) stands as a critical event in the advancement of atherosclerosis (AS).
Wei Lu, Guoqing Wan, He Zhu, Tao Zhu, Xinmei Zhang   +4 more
doaj   +1 more source

Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation

Molecules, 2017
Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products.
You Chul Chung, Seoyeon Kim, Jin Hwa Kim, Geun Soo Lee, Jung No Lee, Nam Ho Lee, Chang-Gu Hyun   +6 more
doaj   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-κb/ERK/p38 signaling pathways

Chinese Medicine
Background Postmenopausal osteoporosis is a chronic metabolic bone disease caused by excessive osteoclast formation and function. Targeting osteoclast differentiation and activity can modulate bone resorption and alleviate osteoporosis.
Cong Wang, Rong Zeng, Yong Li, Rongxin He   +3 more
doaj   +1 more source

Satellite cell count, VO2max, and p38 MAPK in inactive to moderately active young men

, 2011
Satellite cells (SCs) are responsible for muscle repair following strenuous exercise or injury. SC responses to intervention have been studied, but most studies do not discuss or take into account the substantial variability in SC number among young ...
Brooks, Naomi, van de Vyver M., K. H. Myburgh, Niesler, Carola U, Myburgh K.H., Niesler CU, C. U. Niesler, Macaluso F., K. Tubbergh, Myburgh, Kathryn H, Brooks N.E., van de Vyver M, M. Vyver, Macaluso, Frank, MACALUSO, FILIPPO, Van Tubbergh K., Van Tubbergh K, Niesler C.U., van de Vyver, Mark, Van Tubbergh, Karen, Myburgh KH, F. Macaluso, Brooks NE, N. E. Brooks, Macaluso, F., van de Vyver, M., Niesler, C. U., Myburgh, K. H., Brooks, N. E., Van Tubbergh, K.   +29 more
core   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

SnapShot: p38 MAPK Signaling

Cell, 2013
Mitogen-activated protein kinase (MAPK) pathways are important regulators of cellular responses to many extracellular stimuli. Typically, eukaryotic cells have several parallel MAPK pathways, which allow the integration of signals from different stimuli.
Natalia Trempolec, Natalia Dave-Coll, Angel R. Nebreda   +2 more
openaire   +2 more sources