Results 111 to 120 of about 281,509 (352)

The Effect of Eight Weeks of Intermittent Rehabilitation Training with Quercetin ‎Nanoliposome on the Apoptotic Indices of P38 and MK2 in Male Rats with Isoproterenol ‎Induced Myocardial Infarction Model [PDF]

Journal of Paramedical Science and Rehabilitation
Purpose:Quercetin is effective in the rehabilitation and treatment of apoptosis caused by cardiac ischemia, however, due to its low solubility in water, it is not suitable for clinical application, which can be improved by turning it into nanoparticles ...
S Ahmadi, F Taghian, Kh Jalali Dehkordi, M Kargar Fard   +3 more
doaj   +1 more source

p38 Mitogen-activated protein kinases on the body surface--a function for p38 delta

, 2003
The p38 family of mitogen-activated protein kinases includes p38 alpha (SAPK2a, CSBP), p38 beta (SAPK2b), p38 delta (SAPK4), and p38 gamma (SAPK3/ERK6).
Eckert, Richard L, Bone, Frederic, Efimova, Tatiana, Balasubramanian, Sivaprakasam, Crish, James F, Dashti, Shervin   +5 more
core   +1 more source

Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β

, 2023
The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various cellular responses to stress conditions, inflammatory signals, and differentiation factors.
Jonah Beenstock, David Engelberg, Arie Admon, Dganit Melamed Kadosh   +3 more
core   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Targeted Degradation of STING by a Neutrophil Membrane‐Coated Nanoplatform Suppresses Microglial Pyroptosis After Subarachnoid Hemorrhage

Advanced Science, EarlyView.
MG1@NM‐Px serves as a microglia‐targeted STING‐degrading nanoplatform for subarachnoid hemorrhage. Following systemic administration, it crosses the blood–brain barrier and accumulates in activated microglia. STP1‐mediated STING ubiquitination and degradation suppress MAPK/inflammasome signaling, GSDME‐mediated pyroptosis, and IL‐1β release, revealing ...
Ruotian Zhang, Kaikun Yuan, Haoyu Zou, Hanfeng Qin, Jiale Liu, Jianda Sun, Feifan Zhang, Yuankui Wang, Tong Wang, Jiaxing Dai, Chunxu Li, Yichi Chen, Yingfeng Tu, Huaizhang Shi   +13 more
wiley   +1 more source

GLUT2 regulation of p38 MAPK isoform protein expression and p38 phosphorylation in male versus female rat hypothalamic primary astrocyte Cultures

IBRO Neuroscience Reports
Recent studies documented regulation of hypothalamic astrocyte mitogen-activated protein kinase (MAPK) pathways, including p38, by the plasma membrane glucose carrier/sensor glucose transporter-2 (GLUT2). Sex-specific GLUT2 control of p38 phosphorylation
Madhu Babu Pasula, Paul W. Sylvester, Karen P. Briski   +2 more
doaj   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

CD133-containing microvesicles promote colorectal cancer progression by inducing tumor angiogenesis

Heliyon
Angiogenesis is an indispensable mechanism in cancer progression, as cancer cells need to establish blood vessels to supply oxygen and nutrients. Extracellular vesicles (EVs) derived from cancer cells act as messengers in the tumor microenvironment and ...
Beomsu Kim, Suhyun Kim, Sungyeon Park, Jesang Ko   +3 more
doaj   +1 more source

Synthesis, characterization and pharmacological evaluation of pyrazolyl urea derivatives as potential anti-inflammatory agents

Acta Pharmaceutica Sinica B, 2017
p38α mitogen activated protein kinase (MAPK) inhibitors provide a novel approach for the treatment of inflammatory disorders. A series of fifteen pyrazolyl urea derivatives (3ao) were synthesized and evaluated for their p38α MAPK inhibition and ...
Kanagasabai Somakala, Mohammad Amir
doaj   +1 more source

p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells

Cell Death and Disease, 2016
The Wnt inhibitor Dickkopf-1 (DKK-1) has been associated with the occurrence of bone metastases in osteotropic prostate cancer by inhibiting osteoblastogenesis.
A. J. Browne, A. Göbel, S. Thiele, L. C. Hofbauer, M. Rauner, T. D. Rachner   +5 more
semanticscholar   +1 more source