Results 121 to 130 of about 218,916 (306)
, 2015 Representative immunoblot of overloaded plantaris tendons demonstrating the ability of SB203580 to prevent the phosphorylation of p38 MAPK. Total p38 MAPK protein is shown as a loading control.
Christopher L. Mendias (702003) +5 more
core +1 more source
Advanced Science, EarlyView.FLJ20021 interacts with XRCC6 to regulate ADI1 transcription and downstream cellular phenotypes in hUSLFs. Reduced FLJ20021 in POP is associated with lower ADI1, increased apoptosis, senescence, and an ECM‐degrading marker profile. Conversely, FLJ20021 overexpression enhances XRCC6‐dependent ADI1 expression, reduces apoptosis and senescence, and shifts
YanFeng Yang +4 more
wiley +1 more source
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
P38 MAPK expression and activation predicts failure of response to CHOP in patients with Diffuse Large B-Cell Lymphoma. [PDF]
, 2015 The p38 MAPK is constitutively activated in B-NHL cell lines and regulates chemoresistance. Accordingly, we hypothesized that activated p38 MAPK may be associated with the in vivo unresponsiveness to chemotherapy in B-NHL patients.Tissue microarrays ...
Chalapud, J Ramón +10 more
core
Acute stimulation of estrogen receptor-α activates p38 MAPK.
, 2013 Hearts were perfused with 100 nM PPT for 1, 2.5 or 5 minutes. A. p38 activation was assessed with immunoblot analysis of myocardium homogenates with an antibody against phosphorylated p38, and normalized to total p38. B.
Nirmala Chinnappareddy (313373) +2 more
core +1 more source
Advanced Science, EarlyView.Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola +10 more
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Advanced Science, EarlyView.p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv +15 more
wiley +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Autoinflammatory disorders (AIDs) are a clinically heterogeneous group of inborn errors of immunity primarily caused by dysregulation in the innate immune system. Clinical diagnosis is often challenging due to clinical heterogeneity and the overlapping phenotypes with other inborn errors of immunity and monogenic conditions that mimic AIDs ...
Vaishnavi Ashok Badiger +28 more
wiley +1 more source
5-MTP blocks p38 MAPK activation.
, 2016 (A) and (B) Activation of p38, Src and ERK½ was determined in HUVECs treated with VEGF or pro-inflammatory cytokines. Upper panels show representative blots and lower panels show the densitometry of p-p38 MAPK.
Yi-Fu Wang (1915039) +4 more
core +1 more source