Results 121 to 130 of about 281,509 (352)

p38 alpha and p38 gamma Mediate Oncogenic ras-induced Senescence through Differential Mechanisms

, 2009
Oncogene-induced senescence is a tumor-suppressive defense mechanism triggered upon activation of certain oncogenes in normal cells. Recently, the senescence response to oncogene activation has been shown to act as a bona fide barrier to cancer ...
Deng, Qingdong（Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA）, Hong, Lixin, 韩家淮, Sun, Peiqing（Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA）, Liao, Rong（Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA）, Han, Jiahuai, Kwong, Jinny（Scripps Res Inst, Dept Mol Biol, La Jolla, CA 91037 USA）   +6 more
core   +1 more source

A Programmable Calcification Nanoplatform for Loco‐Regional Calcification‐Immune Hepatocellular Carcinoma Therapy

Advanced Science, EarlyView.
An in situ‐grown BP‐CaO2 nanoplatform supplies coordinated Ca2+, endogenous phosphate, and oxidative stress to convert tumor calcification from a passive endpoint into an active immune‐remodeling process. Widespread hydroxyapatite deposition is visualized by CT, while multi‐omics reveals MCOLN2 as a calcium‐responsive mediator linking biomineralization
Long Liu, Peng Li, Zhixiang Lu, Shuqin Xu, Juanjuan Wang, Kai Ma, Haodong Yu, Can Zhou, Hu Chen, Gang Liu, Yi Lyu, Shuang Bai   +11 more
wiley   +1 more source

MiR-497-5p regulates ox-LDL-induced dysfunction in vascular endothelial cells by targeting VEGFA/p38/MAPK pathway in atherosclerosis

Heliyon
Background: The impairment of endothelial cells triggered by oxidized low-density lipoprotein (ox-LDL) stands as a critical event in the advancement of atherosclerosis (AS).
Wei Lu, Guoqing Wan, He Zhu, Tao Zhu, Xinmei Zhang   +4 more
doaj   +1 more source

Pratol, an O-Methylated Flavone, Induces Melanogenesis in B16F10 Melanoma Cells via p-p38 and p-JNK Upregulation

Molecules, 2017
Tyrosinase is the rate-limiting enzyme critical for melanin synthesis. It controls pigmentation in the skin. Activation of tyrosinase is currently the most common approach in the development of tanning and haircare products.
You Chul Chung, Seoyeon Kim, Jin Hwa Kim, Geun Soo Lee, Jung No Lee, Nam Ho Lee, Chang-Gu Hyun   +6 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Cirsilineol inhibits RANKL-induced osteoclast activity and ovariectomy-induced bone loss via NF-κb/ERK/p38 signaling pathways

Chinese Medicine
Background Postmenopausal osteoporosis is a chronic metabolic bone disease caused by excessive osteoclast formation and function. Targeting osteoclast differentiation and activity can modulate bone resorption and alleviate osteoporosis.
Cong Wang, Rong Zeng, Yong Li, Rongxin He   +3 more
doaj   +1 more source

Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: sex-dependent microglial signaling in the spinal cord

Brain, behavior, and immunity, 2015
Previous studies have shown that activation of p38 mitogen-activating kinase (MAPK) in spinal microglia participates in the generation of inflammatory and neuropathic pain in various rodent models.
Sarah R Taves, Temugin Berta, Da-Lu Liu, Sophie Gan, Gang Chen, Yong Ho Kim, Thomas Van de Ven, S. Laufer, R. Ji   +8 more
semanticscholar   +1 more source

Topical alpha-selective p38 MAP kinase inhibition reduces acute skin inflammation in guinea pig

, 2010
Satyanarayana Medicherla, Jing Ying Ma, Mamtha Reddy, Irina Esikova, Irene Kerr, Fabiola Movius, Linda S Higgins, Andrew A ProtterScios Inc, Fremont, CA , USAAbstract: Certain skin pathologies, including psoriasis, are thought to be immune-mediated ...
Satyanarayana Medicherla, Mamtha Reddy, et al, Jing Ying Ma   +3 more
core  

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

SnapShot: p38 MAPK Signaling

Cell, 2013
Mitogen-activated protein kinase (MAPK) pathways are important regulators of cellular responses to many extracellular stimuli. Typically, eukaryotic cells have several parallel MAPK pathways, which allow the integration of signals from different stimuli.
Natalia Trempolec, Natalia Dave-Coll, Angel R. Nebreda   +2 more
openaire   +2 more sources