Results 141 to 150 of about 218,916 (306)
Cancer Management and Research, 2020 Jianjun Jia,1 Xiaomao Li,2 Suiqun Guo,3 Xingmei Xie1 1Department of Obstetrics and Gynecology, The First Affiliated Hospital, Jinan University, Guangzhou 510632, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Third ...
Jia J, Li X, Guo S, Xie X
doaj
The p38 pathway provides negative feedback for Ras proliferative signaling
, 2000 Ras activates three mitogen-activated protein kinases (MAPKs) including ERK, JNK and p38. Whereas the essential roles of ERK and JNK in Ras signaling has been established, the contribution of p38 remains unclear.
韩家淮 +4 more
core
Phosphorylation of p38 MAPK following MP12 infection.
, 2013 A) 106 HSAECs were infected with MP12 (MOI of 3). Cell extracts were obtained at 0, 24, 48 and 72 h post infection and analyzed by western blot with anti-phospho-p38 antibody. Actin was used as loading control.
Jessica Kidd (238257) +8 more
core +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
Effects of MP12 infection on SOD1 and p38 MAPK in HepG2 and 293T cells.
, 2013 A) 106 HepG2 cells were infected with MP12 virus (MOI of 3) and extracts were obtained at 24, 48 and 72 h post infection. Western blots were carried out with antibodies to SOD1, phospho-p38 MAPK (p-p38), Total p38 MAPK (t-p38) and RVFV (Gc).
Jessica Kidd (238257) +8 more
core +1 more source
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Arthritis &Rheumatology, EarlyView.Objective Members of the superfamily of nuclear receptors have been implicated in inflammatory processes and pathologic tissue remodeling and have emerged as attractive targets for pharmaceutical intervention. However, the role of testicular receptor 4 (TR4; or Nr2c2) in fibroblast activation and rheumatologic diseases has not yet been investigated ...
Yun Zhang +16 more
wiley +1 more source
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source
Clinical and Genetic Factors Associated With Regression in Children With Autism Spectrum Disorders
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with complex genetic and environmental underpinnings. A clinically significant subset of children with ASD experience developmental regression (regASD), characterized by the acute loss of previously acquired skills. The mechanisms, predictors, and molecular basis of
Anna Maruani +7 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu +3 more
wiley +1 more source