Results 131 to 140 of about 218,916 (306)
Australian Journal of Social Issues, EarlyView.ABSTRACT Children in out‐of‐home care (OOHC) frequently present with complex behavioural needs. In New South Wales (NSW), behaviour support plans (BSPs) are mandated when restrictive practices, including psychotropic medication, are used. Little research has examined whether the statutory workforce is adequately prepared to meet behaviour support ...
Manisha Abayakoon Stanborough +4 more
wiley +1 more source
, 2008 p38 alpha and p38 beta MAPKs (mitogen-activated protein kinases) share about 80% of their protein sequence identity, but have quite different biological functions.
Zhang, Duanwu +17 more
core
CFMs activate pro-apoptotic MAPK p38 in MB cells.
, 2013 (A, B) Indicated MB cells were either untreated (Control) or treated with noted agents as in figure 2. Staining of the cells was performed using anti-phospho-p38 antibody as detailed in Methods.
Magesh Muthu (425860) +10 more
core +1 more source
Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin +5 more
wiley +1 more source
Investigation of the SUMO-interacting motif of p38
, 2015 SUMOylation is a posttranslational modification by the small ubiquitin-related modifier (SUMO), SUMOylation plays important roles in the regulation of diverse cellular processes. SUMO can interact non-covalently with proteins through the SUMO-interacting
Lin, Tse-yu
core
Activation of p38 MAPK in SARS-CoV-E-PBM mutants infected mice and cells.
, 2014 Lung proteins were extracted from infected mice at 2 dpi. (A) The active phosphorylated (p-p38) and total (p38) p38 MAPK in lungs of three infected mice per condition were evaluated by Western blot analysis.
Raul Fernandez-Delgado (5658874) +6 more
core +1 more source
Angewandte Chemie, EarlyView.Um außergewöhnlich wirksame Wirkstoffe zu entwickeln, ist es erforderlich, über die Bindungsstelle hinaus zu denken. Diese Arbeit zeigt, dass die auf den ersten Blick kontraintuitive Adressierung einer konservierten Region der Kinase zu einer hochselektiven Bindung führen kann.
Nico J. Seidler +20 more
wiley +1 more source
Increased phosphorylated p38 mitogenactivated protein kinase in COPD lungs
, 2013 The p38 mitogen-activated protein kinase (MAPK) pathway is upregulated in chronic obstructive pulmonary disease (COPD). To date, dual labelling to identify cell-type-specific presence of phosphorylated (phospho-)p38 MAPK has not been carried out. Phospho-
Gaffey, Kate +4 more
core +1 more source
Effect of baicalein on the p38 signaling pathway.
, 2014 (A) The protein levels of p38 and p-p38. (B) Phosphorylation density of p38 was digitally scanned.
Zongfang Li (455427) +7 more
core +1 more source
Angewandte Chemie International Edition, EarlyView.To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler +20 more
wiley +1 more source