Results 101 to 110 of about 281,509 (352)

SUMOs Mediate the Nuclear Transfer of p38 and p-p38 during Infection [PDF]

, 2018
The p38 mitogen activated protein kinase (MAPK) signaling pathway has been suggested to play a significant role in the gastric mucosal inflammatory response to chronic Helicobacter pylori (H. pylori) infection.
Ping Hsu, Lynn Marie Powell, Pin Wang, Lynn Powell, Andrew Paul Jarman, Powell, Lynn Marie, Angela Chen, Hsu, Ping I, Jarman, Andrew Paul, Deng Chyang Wu, Wu, Deng Chyang, Wang, Pin Yao, Chen, Angela, Pin Yao Wang, Ping I. Hsu, Te Chung Chen, Deng Wu, Te Chen, Andrew Jarman, Chen, Te Chung   +19 more
core   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Marine sponge‐derived smenospongine preferentially eliminates breast cancer stem‐like cells via p38/AMPKα pathways

Cancer Medicine, 2018
Breast cancer stem cells (CSCs) have been postulated as responsible for therapeutic failure of breast cancer. Novel agents effectively targeting breast CSCs are urging to be discovered to overcome cancer relapse and metastasis.
Jie Tang, Wei Wu, Fan Yang, Liyun Liu, Zhen Yang, Li Liu, Weizhuo Tang, Fan Sun, Houwen Lin   +8 more
doaj   +1 more source

Magnesium lithospermate B protects cardiomyocytes from ischemic injury via inhibition of TAB1-p38 apoptosis signaling

Frontiers in Pharmacology, 2010
Danshen has been used in traditional Chinese medicine (TCM) for hundreds of years to treat cardiovascular diseases. However, its precise cardioprotective components and the underlying mechanism are still unclear.
Chang-Sheng Du, Rui-Fang Yang, Shu-Wei Song, Yi-Ping Wang, Jiu-Hong Kang, Ru Zhang, Ding-Feng Su, Xin Xie, Xin Xie   +8 more
doaj   +1 more source

Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway

Frontiers in Pharmacology, 2020
Emerging evidence reveals that an aberrant accumulation of β-amyloid (Aβ) is the main reason of Alzheimer’s disease (AD) pathogenesis. Thus, inhibition of Aβ-induced neurotoxicity may be promising therapeutic tactics to mitigate AD onset and advance. The
Nana Chen, Nana Chen, Jiao Wang, Yuqi He, Yuqi He, Yuqi He, Yingshu Xu, Yuchuan Zhang, Qihai Gong, Qihai Gong, Qihai Gong, Changyin Yu, Jianmei Gao, Jianmei Gao, Jianmei Gao   +14 more
doaj   +1 more source

Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death

bioRxiv, 2017
The stress activated protein kinases (SAPKs), c-Jun N-terminal kinase (JNK) and p38, are important players in cell fate decisions in response to environmental stress signals.
H. Miura, Yohei Kondo, M. Matsuda, K. Aoki   +3 more
semanticscholar   +1 more source

Envolvimento das proteínas quinases ativadas por mitógenos espinhais na lesão medular traumática em ratos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O envolvimento das proteínas quinases ativadas por mitógenos (MAPKs) em lesões do sistema ...
Martini, Alessandra Cadete
core  

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint.

, 2009
Activation of p38 mitogen-activated protein kinase (MAPK) plays an important role in the G(2)/M cell cycle arrest induced by DNA damage, but little is known about the role of this signaling pathway in the G(1)/S transition.
Cuadrado, Ana, Fernandez-Capetillo, Oscar, Nebreda, Angel R, Lafarga, Vanesa, Bengoechea, Rocio, Lopez de Silanes, Isabel   +5 more
core   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source