Results 101 to 110 of about 218,916 (306)

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

Topical and intraluminal Carolina Rinse Solution in p44/42 and p38 MAP Kinase activation profile in rabbit jejunum after ischemia and reperfusion

Ciência Rural, 2014
The effects of topical and intraluminal Carolina Rinse Solution (CRS) in p44/42 (ERK 1/2) and p38 MAPK activation profile, in rabbit jejunum after ischemia and reperfusion (I/R), were investigated in this study. Fifteen New Zealand rabbits were allocated
Luciana Ramos Gaston Brandstetter, Eugênio Gonçalves de Araújo, Juan Carlos Duque Moreno, Maria Clorinda Soares Fioravanti, Veridiana Maria Brianezi Dignani de Moura, Patrícia de Almeida Machado   +5 more
doaj  

MYST2 histone acetyltransferase promotes lung adenocarcinoma progression by regulating the p38 MAPK signaling pathway

Translational Oncology
Background: Lung cancer, particularly lung adenocarcinoma, poses a significant health challenge due to its high incidence and mortality rates. Despite advancements in targeted therapies, treatment outcomes for lung adenocarcinoma remain unsatisfactory ...
Zhiang Huang, Wanru Zhang, Ping Wang, Mengyao Wu, Yipu Guo, Jingying Chen   +5 more
doaj   +1 more source

p38 MAP kinase mediates CTGF expression in Huh7.5-FL cells.

, 2013
(A) Lysates from Huh7.5 or Huh7.5-FL cells collected at the indicated time points were blotted with Phospho-p38, Phospho-JNK, Phospho-ERK, p38, JNK and ERK antibodies.
Tirumuru Nagaraja (304219), Li Chen (5749), Anuradha Balasubramanian (304221), Andrew Leask (18879), Appakkudal R. Anand (304228), Samson T. Jacob (249655), Ramesh K. Ganju (87726), Kalpana Ghoshal (144593), Jerome E. Groopman (124833), David R. Brigstock (304226)   +9 more
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

SUMOs mediate the nuclear transfer of p38 and p-p38 during Helicobacter pylori infection

, 2016
p38 mitogen-activated protein kinase (MAPK) is of the essence in the cell\ue2s response to environmental stresses, cytokines and DNA damage. p38 is distributed both in the cytosol and nucleus, and cytosolic p38 translocates into the nucleus in response ...
Wang, Pin-Yao
core  

Changes in hepatic p38 MAPK activation after hemorrhage.

, 2013
The activation of p38 MAPK was assessed by Western blotting analysis. p38 MAPK phosphorylation levels, shown on the vertical axis in B, were determined after normalization using the density ratio of the phosphorylated p38 MAPK band (p-p38 MAPK in A ...
Noriyuki Tanaka (169920), Hiroaki Sato (207336), Toshiko Tanaka (174638)   +2 more
core   +1 more source

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Thromboxane A2 Modulates de novo Synthesis of Adrenal Corticosterone in Mice via p38/14‐3‐3γ/StAR Signaling

Advanced Science
Prostanoids are endogenous lipid bioactive mediators that play essential roles in physiological processes such as glucocorticoid secretion. Here, it is found that the thromboxane (Tx)A2 receptor (TP) is highly expressed in the adrenal cortex of mice ...
Shuai Yan, Yuanyang Wang, Bei Wang, Shengkai Zuo, Ying Yu   +4 more
doaj   +1 more source