Results 1 to 10 of about 25,432,439 (260)

Inhibition of p-mTOR represses PS1 transcription by reducing p-JNK [PDF]

Frontiers in Bioscience-Landmark, 2020
Presenilin-1 (PS1) is the catalytic subunit of gamma-secretase. PS1 cleaves beta-amyloid precursor protein (APP) to produce Abeta peptide and Notch 1 receptor to release Notch intracellular domain (NICD) in the cytoplasm.
Hriday K. Das, Silahis S. Hontiveros
doaj   +3 more sources

The Prognostic Significance of Anisomycin-Activated Phospho-c-Jun NH2-Terminal Kinase (p-JNK) in Predicting Breast Cancer Patients’ Survival Time

Frontiers in Cell and Developmental Biology, 2021
This study aims to investigate the prognostic significance of p-JNK in breast cancer patients receiving neoadjuvant chemotherapy (NACT) and analyze the relationship between anisomycin, p-JNK.
Li Chen, Xuantong Zhou, Xiangyi Kong, Zhaohui Su, Xiangyu Wang, Sen Li, Aiping Luo, Zhihua Liu, Yi Fang, Jing Wang   +9 more
doaj   +1 more source

TLR9-JNK signaling pathway regulates hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the role and mechanism of Toll-like receptor 9 (TLR9) in hypoxia-induced proliferation of rat pulmonary artery smooth muscle cells (RPASMCs).
WU Qijian, WU Qijian, ZHANG Erlong, ZHANG Erlong, SUN Binda, SUN Binda   +5 more
doaj   +1 more source

KLF14 activates the JNK-signaling pathway to induce S-phase arrest in cervical cancer cells

Frontiers in Immunology, 2023
ObjectiveTo explore the role of Krüppel-like factor 14 (KLF14) and its underlying mechanism(s) of action in cell-cycle regulation in cervical cancer.MethodsLentiviral infection was used to construct KLF14, KLF14 zinc-finger structural mutations, and ...
Ying Du, Hui Ye, Mei Lin, Lili Cao, Lili Cao   +4 more
doaj   +1 more source

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease [Retraction]

International Journal of COPD, 2023
Liu CY, Wu JH, Chen ZY, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:2375–2383. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj  

D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells

BMC Cell Biology, 2006
Background The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells. The mechanism of mammalian JNK
Iordanov Mihail S, Subbian Ezhilkani, Ryabinina Olga P   +2 more
doaj   +1 more source

Selenium regulates the mitogen-activated protein kinase pathway to protect broilers from hexavalent chromium-induced kidney dysfunction and apoptosis

Ecotoxicology and Environmental Safety, 2022
Hexavalent chromium [Cr (VI)] is a common environmental pollutant. Although selenium (Se) can antagonize the toxicity of Cr (VI), the specific underlying mechanism has not been identified.
Yanbing Zhao, Huan Zhang, Dezheng Hao, Jingqiu Wang, Ruixin Zhu, Weina Liu, Ci Liu   +6 more
doaj   +1 more source

The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation

International Journal of COPD, 2021
Zhi-yuan Chen,1 Yi Zhang,1 Jian-hua Wu,1 Xiao-hua Gao,1 Chun-ling Huang,2 Yu-mei Lin,1 Xiao-ting Xu,1 Yan Li1 1Department of Anesthesiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, People’s Republic of China ...
Chen Z, Zhang Y, Wu J, Gao X, Huang C, Lin Y, Xu X, Li Y   +7 more
doaj  

Wnt-5a/JNK is involved in PM2.5-induced expression of IL-6 and TNF-α of human bronchial epithelial cell line 16HBE [PDF]

Jichu yixue yu linchuang, 2021
Objective To explore whether PM2.5 induces the secretion of IL-6 and TNF-α in 16HBE via the Wnt-5a/JNK signaling pathway. Methods The research was implemented by rats and 16HBE cells. Rats were divided into control group and motor vehicle exhaust(MVE)
ZOU Wei-feng, WANG Xiao-qian, SHENG Qing, ZHU Tao, ZHOU Xiao-ting
doaj  

Synaptic and genomic responses to JNK and AP-1 signaling in Drosophila neurons

BMC Neuroscience, 2005
Background The transcription factor AP-1 positively controls synaptic plasticity at the Drosophila neuromuscular junction. Although in motor neurons, JNK has been shown to activate AP-1, a positive regulator of growth and strength at the larval NMJ, the ...
Bohmann Dirk, Patel Chirag, Navratilova Zaneta, Narayanan Radhakrishnan, Etter Paul D, Jasper Heinrich, Ramaswami Mani   +6 more
doaj   +1 more source