Results 1 to 10 of about 31,026,078 (152)

Relationship Between c-Jun N-terminal Kinase and Depression [PDF]

E3S Web of Conferences, 2020
Depression is one of the most common emotional disorders. The cause of depression is still not clear. C-Jun N-terminal kinase (JNK) is one number of mitogen activated protein kinase (MAPK) family, which is closely related to the occurrence of many ...
Ma Hongpeng
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c-Jun N-terminal kinase signaling in aging [PDF]

Frontiers in Aging Neuroscience
Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities.
Yihao Li, Li You, Eugenie Nepovimova, Vojtech Adam, Zbynek Heger, Klaudia Jomova, Marian Valko, Qinghua Wu, Qinghua Wu, Kamil Kuca, Kamil Kuca   +10 more
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c-Jun N-Terminal Kinase: A Spatiotemporal Regulator of Cell Fate and Function [PDF]

Biology
c-Jun N-terminal kinase (JNK) is a highly conserved, stress-activated protein kinase that plays key roles in cellular development and cell fate. An extensive study over more than 30 years has identified roughly 100 substrates for this kinase including ...
Seth Thesing, Mohammed Salahuddin, Emily Okonek, Ryan L. Hanson   +3 more
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On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory [PDF]

Frontiers in Behavioral Neuroscience, 2022
c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals.
Janine I. Rossato, Janine I. Rossato, Andressa Radiske, Andressa Radiske, Maria Carolina Gonzalez, Maria Carolina Gonzalez, Lia R. M. Bevilaqua, Martín Cammarota   +7 more
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c‐Jun N‐terminal kinase 3 as a permissive regulator of β‐cell incretin responsiveness [PDF]

Journal of Diabetes Investigation
Yuji Yamazaki
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Stressor-like effects of c-Jun N-terminal kinase (JNK) inhibition. [PDF]

PLoS ONE, 2012
There is an urgent need for novel treatment strategies for stressor related disorders, particularly depression and anxiety disorders. Indeed, existing drug treatments are only clinically successful in a subset of patients and relapse is common.
Melanie Clarke, Rowan Pentz, Jessica Bobyn, Shawn Hayley   +3 more
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C-Jun N-terminal kinase inhibitors: Structural insight into kinase-inhibitor complexes

Computational and Structural Biotechnology Journal, 2020
The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such as ...
Men Thi Hoai Duong, Joon-Hwa Lee, Hee-Chul Ahn   +2 more
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Alarmins and c-Jun N-Terminal Kinase (JNK) Signaling in Neuroinflammation

Cells, 2020
Neuroinflammation is involved in the progression or secondary injury of multiple brain conditions, including stroke and neurodegenerative diseases.
Nina D. Anfinogenova, Mark T. Quinn, Igor A. Schepetkin, Dmitriy N. Atochin   +3 more
doaj   +1 more source

Comprehensive In Silico Analysis of Christinin Molecular Behaviour from Ziziphus spina-christi Leaves on Propionibacterium acnes

Pharmaceutical Sciences and Research, 2021
The role of in silico studies in the discovery of new drugs is very important and interesting in the recent years, where the results can be used as confirmation of the results of in vitro tests carried out experimentally in the laboratory.
Fitrianti Darusman, Taufik Muhammad Fakih   +1 more
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Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis

Cells, 2020
The c-Jun-N-terminal kinase (JNK) is a critical mediator involved in various physiological processes, such as immune responses, and the pathogenesis of various diseases, including autoimmune disorders.
Benjamin Lai, Chien-Hsiang Wu, Jenn-Haung Lai   +2 more
doaj   +1 more source