Results 31 to 40 of about 103,535 (116)

c-Jun-N-Terminal Kinase Signaling Is Involved in Cyclosporine-Induced Epithelial Phenotypic Changes

Journal of Transplantation, 2012
Tubular epithelial cells play a central role in the pathogenesis of chronic nephropathies. Previous toxicogenomic studies have demonstrated that cyclosporine- (CsA-) induced epithelial phenotypic changes (EPCs) are reminiscent of an incomplete epithelial
Nicolas Pallet, Eric Thervet, Dany Anglicheau   +2 more
doaj   +1 more source

Activation of c-Jun N-Terminal Kinase Cascades Is Involved in Part of the Neuronal Degeneration Induced by Trimethyltin in Cortical Neurons of Mice

Journal of Pharmacological Sciences, 2009
The organotin trimethyltin (TMT) is known to cause neuronal degeneration in the central nervous system. A systemic injection of TMT produced neuronal damage in the cerebral frontal cortex of mice.
Makoto Shuto, Keiichi Seko, Nobuyuki Kuramoto, Chie Sugiyama, Koichi Kawada, Masanori Yoneyama, Reiko Nagashima, Kiyokazu Ogita   +7 more
doaj   +1 more source

Tolerance to the Antinociceptive Effects of Chronic Morphine Requires C-Jun N-Terminal Kinase

Molecular Pain, 2015
Background Morphine and fentanyl are opioid analgesics in wide clinical use that act through the μ-opioid receptor (MOR). However, one limitation of their long-term effectiveness is the development of tolerance. Receptor desensitization has been proposed
David J. Marcus, Michael Zee, Alex Hughes, Matthew B. Yuill, Andrea G. Hohmann, Ken Mackie, Josée Guindon, Daniel J. Morgan   +7 more
doaj   +1 more source

Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro

Czech Journal of Animal Science, 2013
Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture.
M. Sedmíková, J. Petr, A. Dörflerová, J. Nevoral, B. Novotná, T. Krejčová, E. Chmelíková, L. Tůmová   +7 more
doaj   +1 more source

c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination

Scientific Reports, 2021
During Central Nervous System ontogenesis, myelinating oligodendrocytes (OLs) arise from highly ramified and proliferative precursors called oligodendrocyte progenitor cells (OPCs).
Martina Lorenzati, Enrica Boda, Roberta Parolisi, Martino Bonato, Tiziana Borsello, Thomas Herdegen, Annalisa Buffo, Alessandro Vercelli   +7 more
doaj   +1 more source

c-Jun N-terminal Kinase Contributes to Norepinephrine-Induced Contraction Through Phosphorylation of Caldesmon in Rat Aortic Smooth Muscle

Journal of Pharmacological Sciences, 2006
.: Vascular smooth muscle contraction is mediated by activation of extracellular signal-regulated kinase (ERK) 1/2, an isoform of mitogen-activated protein kinase (MAPK).
Youn Ri Lee, Chang-Kwon Lee, Hyo-Jun Park, Hyojin Kim, Junghwan Kim, Jaeheung Kim, Keun Sang Lee, Yun Lyul Lee, Kyung Ok Min, Bokyung Kim   +9 more
doaj   +1 more source

Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense. [PDF]

PLoS ONE, 2012
The c-Jun N-terminal kinase (JNK) - 1 pathway has been implicated in the cellular response to stress in many tissues and models. JNK1 is known to play a role in a variety of signaling cascades, including those involved in lung disease pathogenesis ...
Jos Van der Velden, Yvonne M W Janssen-Heininger, Sivanarayna Mandalapu, Erich V Scheller, Jay K Kolls, John F Alcorn   +5 more
doaj   +1 more source

FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy

Scientific Reports, 2017
FK866 exhibits a protective effect on D-galactosamine (GaIN)/lipopolysaccharide (LPS) and concanavalin A (ConA)-induced acute liver failure (ALF), but the mechanism by which FK866 affords this benefit has not yet been elucidated.
Enshuang Guo, Renlong Li, Jiankun Yang, Jun Zhang, Anyi Li, Yan Yang, Shenpei Liu, Anding Liu, Xiaojing Jiang   +8 more
doaj   +1 more source

Involvement of JNK and Caspase Activation in Hoiamide A-Induced Neurotoxicity in Neocortical Neurons

Marine Drugs, 2015
The frequent occurrence of Moorea producens (formerly Lyngbya majuscula) blooms has been associated with adverse effects on human health. Hoiamide A is a structurally unique cyclic depsipeptide isolated from an assemblage of the marine cyanobacteria M ...
Zhengyu Cao, Xichun Li, Xiaohan Zou, Michael Greenwood, William H. Gerwick, Thomas F. Murray   +5 more
doaj   +1 more source

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.

PLoS Genetics, 2021
Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function.
Abigail O Smith, Julie A Jonassen, Kenley M Preval, Roger J Davis, Gregory J Pazour   +4 more
doaj   +1 more source