Results 41 to 50 of about 103,535 (116)

Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.

PLoS ONE, 2012
Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function.
István Vadász, Laura A Dada, Arturo Briva, Iiro Taneli Helenius, Kfir Sharabi, Lynn C Welch, Aileen M Kelly, Benno A Grzesik, G R Scott Budinger, Jing Liu, Werner Seeger, Greg J Beitel, Yosef Gruenbaum, Jacob I Sznajder   +13 more
doaj   +1 more source

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Nature Communications, 2017
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced ...
Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin   +8 more
doaj   +1 more source

Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells[S]

Journal of Lipid Research, 2012
Pulmonary artery endothelial plexiform lesion is responsible for pulmonary vascular remodeling (PVR), a basic pathological change of pulmonary arterial hypertension (PAH).
Jun Ma, Lei Zhang, Weina Han, Tingting Shen, Cui Ma, Yun Liu, Xiaowei Nie, Mengmeng Liu, Yajuan Ran, Daling Zhu   +9 more
doaj   +1 more source

Comparative study of the efficacy of pulsed electromagnetic field and low level laser therapy on mitogen-activated protein kinases

Biochemistry and Biophysics Reports, 2017
Mitogen-Activated Protein Kinases (MAPKs) consist of three major signaling members: extracellular signal-regulated kinase (ERK), p38 and C-JUN N-terminal kinase (JNK).
Ayman M. El-Makakey, Radwa M. El-Sharaby, Mohammed H. Hassan, Alaa Balbaa   +3 more
doaj   +1 more source

Role of the phosphatase PP4 in the activation of JNK-1 in prostate carcinoma cell lines PC-3 and LNCaP resulting in increased AP-1 and EGR-1 activity

Biological Research, 2005
The specific signaling connections between the mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (JNK-1) and phosphatases PP4 and M3/6, affecting the family of early nuclear factors, is complex and remains poorly understood.
JUAN INOSTROZA, LEONARDO SÁENZ, GLORIA CALAF, GERTRUDIS CABELLO, EDUARDO PARRA   +4 more
doaj  

c-Jun N-terminal kinase (JNK) cooperates with Gsk3β to regulate Dishevelled-mediated microtubule stability

BMC Cell Biology, 2007
Background Wnt factors are a large family of signaling molecules that play important roles in the regulation of cell fate specification, tissue polarity and cell movement.
Salinas Patricia C, Ciani Lorenza
doaj   +1 more source

Tricholoma matsutake polysaccharides suppress excessive melanogenesis via JNK-mediated pathway: Investigation in 8- methoxypsoralen induced B16–F10 melanoma cells and clinical study

Heliyon
Skin hyperpigmentation is a worldwide condition associated with augmented melanogenesis. However, conventional therapies often entail various adverse effects.
Yang Yang, Zheng Lv, Quan An, Detian Xu, Longjie Sun, Yiming Wang, Xuexue Chen, Xue Shao, Tong Huo, Shuangrui Yang, Jiali Liu, Haoshu Luo, Qianghua Quan   +12 more
doaj   +1 more source

LINC02257 regulates colorectal cancer liver metastases through JNK pathway

Heliyon
Background: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of colorectal cancer (CRC) progression, but their roles and underlying mechanisms in colorectal cancer liver metastases (CRLMs) remain poorly understood.
Xiangan Wu, Xiaokun Chen, Xiao Liu, Bao Jin, Yuke Zhang, Yuxin Wang, Haifeng Xu, Xueshuai Wan, Yongchang Zheng, Lai Xu, Yi Xiao, Zhengju Chen, Haiwen Wang, Yilei Mao, Xin Lu, Xinting Sang, Lin Zhao, Shunda Du   +17 more
doaj   +1 more source

Mechanism of polysaccharide from Arthrospira platensis in regulating inflammatory response induced by porcine pseudorabies virus in porcine alveolar macrophages

Siliao yanjiu
This study aimed to investigate the regulatory effect and mechanism of polysaccharide component 1 from Arthrospira platensis (PAP-1) on the inflammatory response induced by porcine pseudorabies virus (PRV) in porcine alveolar macrophages cells (3D4/2 ...
YUAN Haifeng, HOU Zongyuan, WANG Yaqi, LIANG Huangming, HU Tingjun   +4 more
doaj  

Physical exercise elicits UPR^mt in the skeletal muscle: The role of c-Jun N-terminal kinase. [PDF]

Mol Metab, 2023
Gaspar RS, Katashima CK, Crisol BM, Carneiro FS, Sampaio I, Silveira LDR, Silva ASRD, Cintra DE, Pauli JR, Ropelle ER.   +9 more
europepmc   +1 more source