Results 11 to 20 of about 103,535 (116)
c-Jun N-Terminal Kinase as a Therapeutic Target in Experimental Autoimmune Encephalomyelitis
Cells, 2020 c-Jun N-terminal kinase (JNK) is upregulated during multiple sclerosis relapses and at the peak of experimental autoimmune encephalomyelitis (EAE).
Maud Bagnoud +8 more
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Research progress on the inflammatory mechanisms of cholestatic liver injury [PDF]
Jichu yixue yu linchuang, 2022 Cholestatic liver injury (CLI) is a liver disease with high mordity. Accumulation of bile acids in the liver is thought to be a major driver of liver injury during cholestasis.
KANG Jin-yu, LUO Jia, GAO Ze-tian, ZHENG Wen-tao, LIU Ai-ming, SONG Yu-fei
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Journal of Lipid Research, 2006 Sphingosylphosphorylcholine (SPC) has been implicated in a variety of cellular responses, including proliferation and differentiation. In this study, we demonstrate that d-erythro-SPC, but not l-threo-SPC, stereoselectively stimulated the proliferation ...
Eun Su Jeon +6 more
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Tumor Biology, 2017 We previously reported that 37-kDa laminin receptor precursor involved in metastasis of lung adenocarcinoma cancer cells. In this study, we further revealed that hypoxia induced 37-kDa laminin receptor precursor expression and activation of extracellular
Yongan Zhou +6 more
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c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity
Marine Drugs, 2013 Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (
Alberto Muñoz +6 more
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Activation of c-Jun by human cytomegalovirus UL42 through JNK activation.
PLoS ONE, 2020 c-Jun is a major component of the AP-1 transactivator complex. In this report, we demonstrated that AP-1 was activated by the expression of UL42, a human cytomegalovirus-encoded membrane protein that has two PPXY (PY) motifs and a C-terminal ...
Tetsuo Koshizuka, Naoki Inoue
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Activation of c-Jun N-terminal kinase (JNK) during mitosis in retinal progenitor cells. [PDF]
PLoS ONE, 2012 Most studies of c-Jun N-terminal Kinase (JNK) activation in retinal tissue were done in the context of neurodegeneration. In this study, we investigated the behavior of JNK during mitosis of progenitor cells in the retina of newborn rats.
Vinicius Toledo Ribas +3 more
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Baicalin modulates apoptosis via RAGE, MAPK, and AP-1 in vascular endothelial cells during invasion
Innate Immunity, 2019 Glässer’s disease, caused by Haemophilus parasuis , is a chronic disease related to an inflammatory immune response. Baicalin exerts important biological functions.
Shulin Fu +10 more
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Biomedicines, 2022 Non-alcoholic fatty liver (NAFL) is the most common chronic liver disease. Activation of mitogen-activated kinases (MAPK) cascade, which leads to c-Jun N-terminal kinase (JNK) activation occurs in the liver in response to the nutritional and metabolic ...
Robert W. M. Min +4 more
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Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes
Cells, 2020 Obesity has been described as a global epidemic and is a low-grade chronic inflammatory disease that arises as a consequence of energy imbalance. Obesity increases the risk of type 2 diabetes (T2D), by mechanisms that are not entirely clarified. Elevated
Justin Hou Ming Yung, Adria Giacca
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